European Sleep Research Laboratories

Sleepcenter SEIN Zwolle-Groningen

Current Announcements - International Sleep Medicine Course 2014, November 17-20, St Michielsgestel, Netherlands (Netherlands, Belgium, UK): organized by a committee with Weerd as chairman.
- Age and Sleep One day meeting on Sleep during Lifetime, Slotervaart Hospital, Amsterdam, 2014, May 23.

Stichting Epilepsie Instellingen Nederland (SEIN)

Al de Weerd
Postbox 563
8000 AN Zwolle Netherlands

Position Head of sleepcenter Phone +31 38 8457185 Fax +31 38 8457170 Contact E-Mail Website   Research Domain
  • Clinical

  • Paediatric Sleep Disorders
  • Behavioural Sleep Disorders
  • Neurological Sleep Disorders
  • Biological Rhythms
  • Sleep and Psychiatry-Personality Disorders
  • Sleep and Ageing

Laboratory Description Referral sleepcenter at three locations (Zwolle and Groningen and -in collaboration with GGZ Drenthe- in Assen, especially for sleep disorders in patients with psychiatric disorders). App. 1000 new patients/year with all categories of pathology. Close connection with a referral epilepsy center. All diagnostic techniques except PET are available. Large, multidisciplinary staff. Therapies: CBT, other psychological, medication, CPAP, BiPAP, light/chronotherapy, etc.
Research focussed on the interaction sleep/epilepsy, sleep in (very young) children and adolescents, RLS, sleep in the elderly

Technical Capabilities and areas of expertise Questionnaires, PSG with all possible extensions, actigraphy, assessment of circadian rhythms (continuous temperature, DLMO).
Areas of expertise: see research areas, techniques used

Additional Descriptors, Keywords Referral sleepcenter, patient care, all sleep disorders, sleep/epilepsy, childhood sleep, RLS, sleep in the elderly
Selected Publications in the 5 past years
- de Weerd AW Parkinson's disease related sleep disorders In: Wolters et al (eds) Parkinsonism and related disorders VU University Press 2007:181-9
- de Weerd AW Rest less legs syndrome In: Wolters et al (eds) Parkinsonism and related disorders VU University Press 2007:405-11
- Paulus W, Trenkwalder C, de Weerd AW et al Pathophysiological concepts of RLS Mov Disord 2007;22:1451-6
- Garcia-Borregueoro D, de Weerd AW et al Validation of the Augmentation Severity Rating Scale Sleep Med 2007;8:455-63
- Trenkwalder C, de Weerd AW et al Clinical trials in RLS Recommendations of the Eiropean RLS study group Mov Disord 2007;22: supp 18:495-504
-Kemlink D, de Weerd AW et al Family based association study of the RLS loci 2 and 3 in an European population Mov Disord 2007;22:207-12
-Winkelmann J, de Weerd AW et al. Genetics of RLS: state of the art and future directions Mov Disord;22: supp 18:440-458
- Festen D, de Weerd AW et al Psychomotor development in infants with Prader Willi syndrome and associations with SBD Paediatr Res 2007;62:221-4
- Hofstra W, de Weerd AW et al How to assess circadian rhythms in epilepsy Epil Behav 2008;13:438-44
- Festen D, de Weerd AW et al Cognition and behavour in children with Prader Willi syndrome Am J Med Genet 2008;146:3018-25
- Trenkwalder C, de Weerd AW et al Efficacy of rotigotine for treatment of RLS Lancet Neurol 2008;7:595-604
- Hofstra W, de Weerd AW et al Circadian rhythms in epilepsy Sleep Med Review 2009;13:413-20
- de Lind van Wijngaarden R, de Weerd AW et al Relationship between adrenal deficiency and sleep related breaathing disorder in Prader Willi syndrome J Clin Endocrinol Metabol 2009
-Hofstra W, de Weerd AW et al Temporal distribution of clinical seizures over the 24 hr day Epilepsia 2009;50:2019-26
- Hofstra W, de Weerd AW et al Circadian rhythms in seizures detected by intracranial ECoG monitoring Epil Bhav 2009;14:617-21
- Hogl B, de Weerd AW et al Prgressive development of augmentation during longterm treatment with levo-dopa in RLS J Neurol 2009
- de Weerd AW How to register Sleep and Wake In: van Dijk J (ed) Clinical Neurophysiology Leiden Boerhaave commission 2010:33-44
- Hofstra W, de Weerd AW et al Chronotypes and sleep preferences in epilepsy patients Chronobiol Int 2010;27:1271-86
Hofstra WA, de Weerd AW Timing of temporal and frontal seizures in relation to the circadian phase Epilepsy Res 2011;94:158-62
van Golde E, Gutter T, de Weerd AW Sleepdisturbances in people with epilepsy Sleep Medicine Reviews
Hofstra WA, van der Palen J, de Weerd AW Morningness and eveningness: when do patients take their antiepileptic drugs? Epil Behavior 2012;23:320-323
Gutter Th, de Weerd AW Effects of daytime secondarily generalized epileptic seizures on sleep during the following night.Epilepsy Behavior 2012;prepub.
Hagebeuk EEO, van den Bossche RAS, de Weerd AW Respiratory and sleep disorders in female children with atypical Rett syndrome caused by mutations in the CDKL5 gene Dev Med Child Neurol 2012;DOI 10.111/j.1469-8749.2012.04432x
Hofstra WA, de Weerd AW Seizures, epilepsy and circadian rhythms In: MM Grigg-Bamberger, N Foldvary-Schaeffer eds. Sleep Medicine Clinics Philadelphia Saunders/Elsevier 2012;7:99-104
-De Weerd AW, Schreuder KE Slaap tijdens de levensloop In: Verbraecken J et al. eds. Leerboek slaap en slaapstoornissen Acco, Leuven, 2013:83-92.
-De Weerd AW, de Volder I. Slaap en epilepsie In: Verbraecken J et al. eds. Leerboek slaap en slaapstoornissen Acco, Leuven, 2013:572-576.
-Rijsman RM, de Weerd AW, Poirrier R Restless Legs Syndroom . In: Verbraecken J et al. eds. Leerboek slaap en slaapstoornissen Acco, Leuven, 2013:589/599.
-De Weerd AW, Vandenbussche N Indicaties voor respiratoire en niet/respiratoire investigaties bij kinderen met een slaapstoornis In: Verbraecken J et al. eds. Leerboek slaap en slaapstoornissen Acco, Leuven, 2013:654/656.
-Van der Kooi AW, Tulen J, van Eijk M, de Weerd AW, van Uitert M, van Munster B, Slooter AJC Sleep monitoring by actigraphy in short-stay ICU patients Critical Care Nurs Q 2013;36, in press.
-De Weerd AW. Restless Legs Syndrome or Willis-Ekbom Disease. What is in a name? Sleep Medicine 2013;14:381-82
-Kasteleijn-NolstTrenite D, de Weerd AW, Beniczky S Chronodependency and provocative factors in juvenile myoclonic epilepsy Epil Behav 2013;28:S25-29
-Gutter Th, Brouwer OF, de Weerd AW Subjective sleep disturbances in children with partial epilepsy and their effects on quality of life Epil Behav 2013;28:481-488
-Kamphuis J, Karsten J, de Weerd AW, Lancel M. Sleep disturbances in a forensic psychiatric population Sleep Medicine 2013;
-Busger op Vollenbroek R, de Weerd AW. Stikgevoelens in de nacht. Ned Tijdschr Geneesk 2013;157:1906-1920

Key Publications of the Laboratory See above
Current/Completed Grants (past 5 years) UCB: Prevalence of sleep disorders in epilepsy
Christelijke Vereeniging: idem
Christelijke Vereeniging: Circadian rhythms in epilepsy

Total grants in these years: Euro 250.000

Other laboratory Members
Title MD First Name Mireille Last Name Bourez-Swart Position neurologist, staff member E-Mail  
Title MSc,MD First Name Karel Last Name Schreuder Position MD, sleep specialist, staff member E-Mail  
Title MSc First Name Astrid Last Name Hamoen Position psychologist, staff member E-Mail  
Title MSc First Name Saskia Last Name Boukamp Position psychologist, staff member E-Mail  
Title MSc First Name Else Last Name Redlich Position psychologist, stafmember E-Mail  
Title BSc First Name Renilde Last Name van den Bossche Position senior technician, staff member E-Mail  
Title PhD First Name Raphaelle Last Name Ferri Institution Troina  
Title PhD,MD First Name Luigi Last Name Ferini Strambi Institution Milano  
First Name Claudia Last Name Trenkwalder Institution Kassel  
Past Members