European Sleep Research Laboratories

Parma University - Sleep Disorders Center

University of Parma

Mario Giovanni Terzano
Via Gramsci, 14
43126 Parma Italy

Position Full Professor of Neurology Phone +39 0521 704107 Fax +39 0521 704107 Contact E-Mail   Research Domain
  • Basic Human
  • Clinical
  • Methodology / Technology

  • Neurological Sleep Disorders
  • Sleep Physiology-Neurophysiology in Human
  • Sleep and Body Functions (Cardio-Respiratory, Thermoregulation/Metabolism, Endocrine)
  • Pharmacology – Human

Laboratory Description Human sleep physiology; Mechanisms of sleep regulation; Studies on arousals and cyclic alternating pattern (CAP);
Technology for sleep microstructure analysis; Application of CAP in sleep disorders (OSAS, insomnia, narcolepsy, epilepsy, parasomnias, psychopharamacology, etc.)

Technical Capabilities and areas of expertise Training for macro- and microstructure scoring of human sleep.
Training for cyclic alternating pattern (CAP) analysis
CAP application for diagnosis and treatment of sleep disorders (vide supra).

Additional Descriptors, Keywords PAP titration for OSAS, central apneas and complex-SAS.
Selected Publications in the 5 past years 1.Parrino L, Halasz P, Tassinari CA, Terzano MG. CAP, epilepsy and motor events during sleep: the unifying role of arousal. Sleep Med Rev 2006;10:267-85.
2.Terzano MG, Smerieri A, Del Felice A, Giglia F, Palomba V, Parrino L. Cyclic alternating pattern (CAP) alterations in narcolepsy. Sleep Med 2006;7:619-26.
3.Ferri R, Bruni O, Miano S, Plazzi G, Spruyt K, Gozal D, Terzano MG. The time structure of the cyclic alternating pattern during sleep. Sleep 2006;29:693-9.
4.Nobili L, Sartori I, Terzaghi M, Francione S,Mai R, Tassi L, Parrino L, Cossu M, Lo Russo G. Relationship of epileptic discharges to arousal instability and periodic leg movements in a case of nocturnal frontal lobe epilepsy: a stereo-EEG study. Sleep 2006;29:701-4.
5.Smerieri A, Parrino L, Agosti M, Ferri R, Terzano MG. Cyclic alternating pattern sequences and non-cyclic alternating pattern periods in human sleep. Clin Neurophysiol 2007;118:2305-13.
6.Ferri R, Rundo F, Bruni O, Terzano MG, Stam CJ. Small-world network organization of functional connectivity of EEG slow-wave activity during sleep. Clin Neurophysiol 2007;118:449-56.
7.Miano S, Bruni O, Elia M, Trovato A, Smerieri A, Verrillo E, Roccella M, Terzano MG, Ferri R.Sleep in children with autistic spectrum disorder: a questionnaire and polysomnographic study.Sleep Med. 2007;9 :64-70.
8.Ferri R, Rundo F, Bruni O, Terzano MG, Stam CJ. The functional connectivity of different EEG bands moves towards small-world network organization during sleep. Clin Neurophysiol 2008;119:2026-36.
9.Ozone M, Yagi T, Itoh H, Tamura Y, Inoue Y, Uchimura N, et al. Effects of zolpidem on cyclic alternating pattern, an objective marker of sleep instability, in Japanese patients with psychophysiological insomnia: a randomized crossover comparative study with placebo. Pharmacopsychiatry 2008;41:106-14.
10.Parrino L, Smerieri A, Giglia F, Milioli G, De Paolis F, Terzano MG. Polysomnographic study of intermittent zolpidem treatment in primary sleep maintenance insomnia. Clin Neuropharmacol 2008;31:40-50.
11.Italian REMS Study Group, Manconi M, Ferini-Strambi L, Filippi M, Bonanni E, Iudice A, Murri L, Gigli GL, Fratticci L, Merlino G, Terzano G, Granella F, Parrino L, Silvestri R, Aricò I, Dattola V, Russo G, Luongo C, Cicolin A, Tribolo A, Cavalla P, Savarese M, Trojano M, Ottaviano S, Cirignotta F, Simioni V, Salvi F, Mondino F, Perla F, Chinaglia G, Zuliani C, Cesnik E, Granieri E, Placidi F, Palmieri MG, Manni R, Terzaghi M, Bergamaschi R, Rocchi R, Ulivelli M, Bartalini S, Ferri R, Lo Fermo S, Ubiali E, Viscardi M, Rottoli M, Nobili L, Protti A, Ferrillo F, Allena M, Mancardi G, Guarnieri B, Londrillo F. Multicenter case-control study on restless legs syndrome in multiple sclerosis: the REMS study.Sleep. 2008;3: 944-52.
12.Miano S, Bruni O, Elia M, Scifo L, Smerieri A, Trovato A, Verrillo E, Terzano MG, Ferri R.Sleep phenotypes of intellectual disability: a polysomnographic evaluation in subjects with Down syndrome and Fragile-X syndrome.Clin Neurophysiol. 2008;119:1242-7.
13.Terzano MG, Milioli G, De Paolis F, Parrino L. Z-drugs: comparative tolerability. In: Sleep Disorders. SR Pandi-Perumal et al., eds). Informa UK, 2008; pp.364-78.
14.Parrino L, Milioli G, De Paolis F, Grassi A, Terzano MG. Paradoxical insomnia; the role of CAP and arousals in sleep misperception. Sleep Med 2009;10:1139-45.
15.Parrino L, Ferri R, Zucconi M, Fanfulla F. Commentary from the Italian Association of Sleep Medicine on the AASM manual for the scoring of sleep.and associated events: for debate and discussion. Sleep Med 2009;10:799-808.
16.Bruni O, Novelli L, Miano S, Parrino L, Terzano MG, Ferri R. Cyclic alternating pattern: a window into pediatric sleep. Sleep Med 2010;11:628-36.
17.Carra MC, Macaluso GM, Rompré PH, Huynh N, Parrino L, Terzano MG, Lavigne GJ. Clonidine has a paradoxical effect on cyclic arousal and sleep bruxism during NREM sleep. Sleep 2010; 33:1711-6.
18.Chouvarda I, Rosso V, Mendez MO, Bianchi AM, Parrino L, Grassi A, Terzano M, Cerutti S, Maglaveras N. EEG complexity during sleep: on the effect of micro and macro sleep structure.Conf Proc IEEE Eng Med Biol Soc. 2010;5959-62.
19.Mariani S, Bianchi AM, Manfredini E, Rosso V, Mendez MO, Parrino L, Matteucci M, Grassi A, Cerutti S, Terzano MG. Automatic detection of a phases of the cyclic alternating pattern during sleep.Conf Proc IEEE Eng Med Biol Soc. 2010:5085-8.
20.Chouvarda I, Rosso V, Mendez MO, Bianchi AM, Parrino L, Grassi A, Terzano M, Cerutti S. Assessment of the EEG complexity during activations from sleep.Comput Methods Programs Biomed. 2010 (in press).
21.Terzano MG, Parrino L. Neurological perspectives in insomnia and hyperarousal syndromes. Handb Clin Neurol. 2011;99:697-721.
22.Parrino L, Ferri R, Bruni O, Terzano MG.Cyclic alternating pattern (CAP): The marker of sleep instability.Sleep Med Rev 2011 (in press).
23.Poryazova R, Werth E, Parrino L, Terzano MG, Bassetti CL. Cyclic alternating pattern in narcolepsy patients and healthy controls after partial and total sleep deprivation. Clin Neurophysiol 2011 (in press).
24.Mariani S, Manfredini E, Rosso V, Mendez MO, Bianchi AM, Matteucci M, Terzano MG, Cerutti S, Parrino L. Characterization of A phases during the Cyclic Alternating Pattern of sleep. Clin Neurophysiol 2011 (in press).
25.Carra MC, Rompré PH, Kato T, Parrino L, Terzano MG, Lavigne GJ, Macaluso GM. Sleep bruxism and sleep arousal: an experimental challenge to assess the role of cyclic alternating pattern.J Oral Rehabil. 2011 (in press).

Current/Completed Grants (past 5 years) FIL and PRIN Grants from Ministry of Public Education, University and Research (MIUR).
Other laboratory Members
Title PhD,MD First Name Liborio Last Name Parrino Position Assistant Professor E-Mail  
Title MD First Name Giulia Last Name Milioli Position Resident Neurologist E-Mail  
Title MD First Name Fernando Last Name De Paolis Position Resident Neurologist E-Mail  
Title MD First Name Silvia Last Name Riccardi Position Resident Neurologist E-Mail  
Title MD First Name Roberto Last Name Melej Position Hospital clinical pneumologist E-Mail  
Title MD First Name Robert Last Name Thomas  
First Name Sudhansu Last Name Chokroverty  
First Name Christian Last Name Guilleminault  
Title PhD First Name Max Last Name HIrshkowitz  
Title MD First Name Mark Last Name Mahowald  
Title MD First Name Harvey Last Name Moldofsky  
Title MD First Name Arthur Last Name Walters  
Title MD First Name Claudio Last Name Bassetti  
Title MD First Name Peter Last Name Halasz  
Past Members