European Sleep Research Laboratories

Sleep-Wake-Centre Inselspital

University Hospital
Dept of Neurology

MD
Johannes MATHIS
Freiburgstr. 10
3010 Bern Switzerland


Position Neurological head Phone 004131 6322693 Fax 004131 6329448 Contact E-Mail karolina.krebs@insel.ch Website http://www.schlafmedizin.ch   Research Domain
  • Clinical

Keywords
  • Others
  • Sleep and Medical Disorders
  • Sleep and Ageing
  • Sleep and Psychiatry-Personality Disorders
  • Epidemiology of Sleep
  • Sleep and Body Functions (Cardio-Respiratory, Thermoregulation/Metabolism, Endocrine)
  • Neurological Sleep Disorders

Laboratory Description The clinical sleep-wake-centre Inselspital is a tertiary multidisciplinary sleep centre with close co-operation between neurology, pneumology and psychiatry. The main clinical research area is narcolepsy and other hypersomnias, driving capability in sleepy subjects, parasomnia & nocturnal seizures, restless legs syndrome and sleep apnoea syndrome.
Technical Capabilities and areas of expertise all techniques for clinical workup in sleep-wake disorders are available: polysomnography, multiple sleep latency test, maintenance of wakefulness test, pupillography, steer clear vigilance test, psychomotor vigilance test, driving simulator, actigraphy
Additional Descriptors, Keywords narcolepsy, restless legs syndrome, sleep apnoea syndrome, motor vehicle accidents, excessive daytime sleepiness, nonorganic hypersomnia, parasomnia and epilepsy in sleep
Selected Publications in the 5 past years 1. H.P. Landolt, M. Glatzel, T. Blättler, P. Achermann, C. Roth, J. Mathis, J. Weis, I. Tobler, A. Aguzzi, C.L. Bassetti. Sleep-wake disturbances in sporadic Creutzfeldt-Jakob disease, Neurology 66:1418-1424, 2006.

2. K. E. Hersberger, V.P. Renggli, A. C. Nirkko, J. Mathis, K. Schwegler, K. E. Bloch. Screening for sleep disorders in community pharmacies – evaluation of a campaign in Switzerland. Journal of Clinical Pharmacy and Therapeutics 31:35-41, 2006.

3. J.Zavodny, C.Roth, C.Bassetti, J.Mathis, N.J.Douglas, M.Gugger. Effects of sleep fragmentation on the arousability to resistive loading in NREM and REM sleep in normal men. Sleep 29: 525-532, 2006.

4. K. Schwegler, R. Klaghofer, A. Nirkko, J. Mathis, K. Hersberger, K. Bloch. Sleep and wakefulness disturances in Swiss Pharmacy customers. 2006

5. R.Khatami, D.Zutter, A.Siegel, J.Mathis, F.Donati, C.L.Bassetti. Sleep-wake habits and disorder in a series of 100 adult epilepsy patients – A prospective study. Seizure 15: 299-306, 2006.

6. A.G.Guggisberg, Ch.W.Hess, J.Mathis. The significance of the sympathetic nervous system in the pathophysiology of periodic leg movemnts in sleep. Sleep 30: 755-766, 2007.

7. A.G.Guggisberg, J.Mathis, U.S.Herrmann, Ch.W. Hess. The functional relationship between yawning and vigilance. Behavioural Brain research 179: 159-166, 2007.

8. C.Trenkwalder, H.Benes, G.Luder, H.Svenja, B.Högl, J.Mathis, G.Saletu-Zylharz, M.Leroux. Cabergoline compared to levodopa in the treatment of patients with severe Restless Legs Syndrome: Results from a multicenter, randomized, double-blind, active controlled trial. Mov. Disorders 22:696-703, 2007.

9. R. Khatami, H.P. Landolt, P. Achermann, J. Retey, E. Werth, J. Mathis, C.L. Bassetti. Insufficient Non-REM sleep intensity in narcolepsy-cataplexy. Sleep, Vol. 30, No. 8, 2007.

10. K. Schindler, T. Nyffeler, R. Wiest, M. Hauf, J. Mathis, Ch. W. Hess, R. Müri Theta burst transcranial magenetic stimulation is associated with increased EEG synchronization in the stimulated relative to unstimulated cerebral hemisphere. Neuroscience Letters 438: 31-34, 2008

11. Adrian G. Guggisberg, MD; Christian W. Hess, MD; Johannes Mathis, a Reponse to Drs. Ferri and Zucconi, SLEEP, Vol. 31, No. 1 2008

12. K. Jann, R. Wiest, M. Hauf, K. Meyer, C. Boesch, J. Mathis, G. Schroth, Th. Dierks, Th. Koenig. Bold correlates of continuously fluctuating epileptic activity isolated by independent component analysis. Neuroimage 42: 645-648, 2008.

13. U.S. Herrmann, Ch. W. Hess, A. Guggisberg, C. Roth, M. Gugger, J. Mathis, Sleepiness is not always perceived before falling asleep in healthy, sleep deprived subjects. Sleep Medicine 11: 747-751, 2010

14. H. Hor, Z. Kutalik, Y. Dauvilliers, A. Valesia, G. J. Lammers, C. E. H. M. Donjacour, A. Iranzo, J. Santamaria, R. Peraita Adrados, J. L. Vicario, S. Overeem, I. Arnulf, Th. Ioannis, P. Jennum, S. Knudsen, C. Bassetti, J. Mathis, M. Lecendreux, G. Mayer, P. Geisler, A. Beneto, B. Petit, C. Pfister, J. Vienne, G. Didlot, M. Billiard, G. Ercilla, W. Verduijn, F. H. J. Class, P. Vollenwider, G. Waeber, D. Waterworth, V. Mooser, R. Heinzer, J. S. Beckmann, S. Bergmann, M. Tafti, Genome-wide association study identifies new HLA Class II variants strongly protective against narcolepsy. Nat. Genet. 2010 Sep; 42(9):786-9. Epub 2010 Aug 15


15. C. Rummel, H. Gast, K. Schindler, M. Müller, F. Amor, Ch. W. Hess, J. Mathis, Periodic leg movement during sleep – Detecting hidden periodicities and data-driven group formation. Frontiers in Neuroscience 4:1-14, 2010


16. F. Gradinger, A. Glässel, M. Gugger, A. Cieza, N. Braun, R. Khatami, A. Stucki, W.Schmitt, J. Mathis. Identification of problems in functioning of persons with sleep disorders in a clinical setting using the International Classification of Functioning Disability and Health (ICF): a cross-sectional study. J. Sleep Res. 2010 Sept. 30; doi:10.1111/j. 1365-2869.2010.00888.x

17. U. Kallweit, R. Khatami, F. Pizza, J. Mathis, C. Bassetti, Dopaminergic Treatment in Idiopathic Restless Legs Syndrome: Effects on Subjective Sleepiness, Clinical Neuropharmacology Nov./Dez. 2010/ 33, 276-278

18. F. Gradinger, B. Köhler, R. Khatami, J. Mathis, A. Stucki, A. Cieza, C. Bassetti, Identification of problems in functioning of persons with sleep disorders from the patient perspective using the International Classification of Functioning, Disability and Health (ICF): a qualitative study. Accepted J.Sleep Res. 2011 Mar; 20: 171-82: doi:10.1111/j. 1365-2869.2010.00888.x

19. H.M Vu , C. Hurni, J. Mathis, C.Roth, C.L. Bassetti. Selective REM sleep deprivation in narcolepsy. J.Sleep Res. 20: 50-56 (2011).



Key Publications of the Laboratory 1. U. S. Herrmann, C. W. Hess, A. G. Guggisberg, C. Roth, M. Gugger, and J. Mathis. Sleepiness is not always perceived before falling asleep in healthy, sleep-deprived subjects. Sleep Med 11 (8):747-751, 2010.

2. F. Gradinger, A. Glässel, M. Gugger, A. Cieza, N. Braun, R. Khatami, A. Stucki, W.Schmitt, J. Mathis. Identification of problems in functioning of persons with sleep disorders in a clinical setting using the International Classification of Functioning Disability and Health (ICF): a cross-sectional study. J. Sleep Res. 2010 Sept. 30; doi:10.1111/j. 1365-2869.2010.00888.

3. C. Rummel, H. Gast, K. Schindler, M. Müller, F. Amor, Ch. W. Hess, J. Mathis, Periodic leg movement during sleep – Detecting hidden periodicities and data-driven group formation. Frontiers in Neuroscience 4:1-14, 2010

4. H.M Vu , C. Hurni, J. Mathis, C.Roth, C.L. Bassetti. Selective REM sleep deprivation in narcolepsy. J.Sleep Res. 20: 50-56 (2011).

5. A.G.Guggisberg, Ch.W.Hess, J.Mathis. The significance of the sympathetic nervous system in the pathophysiology of periodic leg movements in sleep. Sleep 30: 755-766, 2007.

J.Zavodny, C.Roth, C.Bassetti, J.Mathis, N.J.Douglas, M.Gugger. Effects of sleep fragmentation on the arousability to resistive loading in NREM and REM sleep in normal men. Sleep 29: 525-532, 2006.


 
Other laboratory Members
 
Title MD First Name Matthias Last Name Gugger Position Pulmonological Head E-Mail matthias.gugger@insel.ch  
Title PhD First Name Corinne Last Name Roth Position Somnologist, head of sleep laboratory E-Mail corinne.roth@insel.ch  
Title MD First Name Wolfgang Last Name Schmitt Position Consultant Psychiatry E-Mail wolfgang.schmitt@gef.be.ch  
Collaborations
 
Title MD First Name Claudio Middle Name L. Last Name Bassetti Position Head Neurocentro Svizzera Italiana  
Title PhD First Name Katharina Last Name Henke Position Assistant Professor Tenur Track Institution University Bern  
Title PhD First Name Mehdi Last Name Tafti Position Head Centre of Integrative Genomics Institution University of Lausanne  
Past Members
 
First Name Uli Last Name Herrmann Position MD E-Mail uli.herrmann@students.unibe.ch  
Title MD First Name Adrian Last Name Guggisberg Position MD E-Mail aguggis@gmail.com