European Sleep Research Laboratories

Department of Sleep Medicine

Current Announcements Edinburgh Sleep Course - 26 to 30 March 2012
Research Fellows - applications always welcome for short or long term posts

Royal Infirmary Edinbrugh
Department of Sleep Medicine


Renata L Riha
51 Little France Crescent
EH164SA Edinburgh United Kingdom


Position Consultant Phone +441312423882 Fax +441312423878 Contact E-Mail rlriha@hotmail.com Website http://www.ed.ac.uk/schools-departments/clinical-sciences/sleep-research-unit/ho   Research Domain
  • Methodology / Technology
  • Clinical

Keywords
  • Instrumentation-Methodology
  • Sleep and Medical Disorders
  • Genetics of Sleep
  • Sleep and Ageing
  • Sleep and Psychiatry-Personality Disorders
  • Sleep and Body Functions (Cardio-Respiratory, Thermoregulation/Metabolism, Endocrine)
  • Behavioural Sleep Disorders
  • Neurological Sleep Disorders

Laboratory Description The Department of Sleep Medicine in the Royal Infirmary of Edinburgh has been diagnosing and treating sleep disorders in adults for almost 30 years. The Unit sees about 2, 500 new patients a year and has a seven-bed facility for performing polysomnography. It also uses home diagnostics with limited sleep studies as first line investigation in possible sleep apnoea. There is a strong focus for research and teaching in the Unit with over 250 original publications, many of which have formed the basis of best practice guidelines in the investigation and treatment of obstructive sleep apnoea on an international level. Our research is currently extending into neurological sleep disorders, including narcolepsy and parasomnias.


Technical Capabilities and areas of expertise Highly experienced research team with a variety of experiences with running large scale randomised trials.
Additional Descriptors, Keywords Clinical/translational
Sleep disordered breathing of any cause
Narcolepsy
Parasomnias

Selected Publications in the 5 past years 1. Hedner J, Grote L, Bonsignore M, McNicholas W, Lavie P, Parati G, Sliwinski P, Barbé F, De Backer W, Escourrou P, Fietze I, Kvamme JA, Lombardi C, Marrone O, Masa JF, Montserrat JM, Penzel T, Pretl M, Riha R, Rodenstein D, Saaresranta T, Schulz R, Tkacova R, Varoneckas G, Vitols A, Vrints H, Zielinski J. The European Sleep Apnoea Database (ESADA): report from 22 European sleep laboratories. Eur
Respir J. 2011 Sep;38(3):635-42

2. Morrison I, Bušková J, Nevšimalová S, Douglas NJ, Riha RL. Diagnosing narcolepsy with cataplexy on history alone: challenging the International Classification of Sleep Disorders (ICSD-2) criteria. Eur J Neurol. 2011 Jul;18(7):1017-20

3. Schmoll C, Lascaratos G, Dhillon B, Skene D, Riha RL. The role of retinal regulation of sleep in health and disease. Sleep Med Rev. 2011 Apr;15(2):107-13

4. Morrison I, Frangulyan R, Riha RL. Beta-blockers as a cause of violent rapid eye movement sleep behavior disorder: a poorly recognized but common cause of violent parasomnias. Am J Med. 2011 Jan;124(1):e11

5. Vennelle M, White S, Riha RL, Mackay TW, Engleman HM, Douglas NJ. Randomized controlled trial of variable-pressure versus fixed-pressure continuous positive airway pressure (CPAP) treatment for patients with obstructive sleep apnea/hypopnea syndrome (OSAHS). Sleep. 2010 Feb;33(2):267-71

6. Vennelle M, Engleman HM, Douglas NJ. Sleepiness and sleep-related accidents in commercial bus drivers. Sleep Breath. 2010 Feb;14(1):39-42

7. Jennum P, Riha RL. Epidemiology of sleep apnoea/hypopnoea syndrome and sleep-disordered breathing. Eur Respir J. 2009 Apr;33(4):907-14

8. Riha RL, Gislasson T, Diefenbach K. The phenotype and genotype of adult obstructive sleep apnoea/hypopnoea syndrome. Eur Respir J. 2009 Mar;33(3):646-55.

9. Cross MD, Mills NL, Al-Abri M, Riha R, Vennelle M, Mackay TW, Newby DE, Douglas NJ. Continuous positive airway pressure improves vascular function in obstructive sleep apnoea/hypopnoea syndrome: a randomised controlled trial. Thorax. 2008 Jul;63(7):578-83.

10. Smith LA, Chong DW, Vennelle M, Denvir MA, Newby DE, Douglas NJ. Diagnosis of sleep-disordered breathing in patients with chronic heart failure: evaluation of a portable limited sleep study system. J Sleep Res. 2007 Dec;16(4):428-35

11. Smith LA, Vennelle M, Gardner RS, McDonagh TA, Denvir MA, Douglas NJ, Newby DE. Auto-titrating continuous positive airway pressure therapy in patients with chronic heart failure and obstructive sleep apnoea: a randomized placebo-controlled trial. Eur Heart J. 2007 May;28(10):1221-7

12. Cross MD, Vennelle M, Engleman HM, White S, Mackay TW, Twaddle S, Douglas NJ. Comparison of CPAP titration at home or the sleep laboratory in the sleep apnea hypopnea syndrome. Sleep. 2006 Nov;29(11):1451-5

13. Hsu CY, Vennelle M, Li HY, Engleman HM, Dennis MS, Douglas NJ. Sleep-disordered breathing after stroke: a randomised controlled trial of continuous positive airway pressure. J Neurol Neurosurg Psychiatry. 2006 Oct;77(10):1143-9

14. Izci B, Vennelle M, Liston WA, Dundas KC, Calder AA, Douglas NJ. Sleep-disordered breathing and upper airway size in pregnancy and post-partum. Eur Respir J. 2006 Feb;27(2):321-7

15. Li HY, Engleman H, Hsu CY, Izci B, Vennelle M, Cross M, Douglas NJ. Acoustic reflection for nasal airway measurement in patients with obstructive sleep apnea-hypopnea syndrome. Sleep. 2005 Dec;28(12):1554-9

16. Riha RL, Brander P, Vennelle M, McArdle N, Kerr SM, Anderson NH, Douglas NJ. Tumour necrosis factor-alpha (-308) gene polymorphism in obstructive sleep apnoea-hypopnoea syndrome. Eur Respir J. 2005 Oct;26(4):673-8

17. Riha RL, Brander P, Vennelle M, Douglas NJ. A cephalometric comparison of patients with the sleep apnea/hypopnea syndrome and their siblings. Sleep. 2005
Mar;28(3):315-20

Key Publications of the Laboratory 1. Hedner J, Grote L, Bonsignore M, McNicholas W, Lavie P, Parati G, Sliwinski P, Barbé F, De Backer W, Escourrou P, Fietze I, Kvamme JA, Lombardi C, Marrone O, Masa JF, Montserrat JM, Penzel T, Pretl M, Riha R, Rodenstein D, Saaresranta T, Schulz R, Tkacova R, Varoneckas G, Vitols A, Vrints H, Zielinski J. The European Sleep Apnoea Database (ESADA): report from 22 European sleep laboratories. Eur
Respir J. 2011 Sep;38(3):635-42

2. Vennelle M, White S, Riha RL, Mackay TW, Engleman HM, Douglas NJ. Randomized controlled trial of variable-pressure versus fixed-pressure continuous positive airway pressure (CPAP) treatment for patients with obstructive sleep apnea/hypopnea syndrome (OSAHS). Sleep. 2010 Feb;33(2):267-71

3. Cross MD, Mills NL, Al-Abri M, Riha R, Vennelle M, Mackay TW, Newby DE, Douglas NJ. Continuous positive airway pressure improves vascular function in obstructive sleep apnoea/hypopnoea syndrome: a randomised controlled trial. Thorax. 2008 Jul;63(7):578-83

4. Smith LA, Chong DW, Vennelle M, Denvir MA, Newby DE, Douglas NJ. Diagnosis of sleep-disordered breathing in patients with chronic heart failure: evaluation of a portable limited sleep study system. J Sleep Res. 2007 Dec;16(4):428-35

5. Cross MD, Vennelle M, Engleman HM, White S, Mackay TW, Twaddle S, Douglas NJ. Comparison of CPAP titration at home or the sleep laboratory in the sleep apnea hypopnea syndrome. Sleep. 2006 Nov;29(11):1451-5

6. Izci B, Vennelle M, Liston WA, Dundas KC, Calder AA, Douglas NJ. Sleep-disordered breathing and upper airway size in pregnancy and post-partum. Eur Respir J. 2006 Feb;27(2):321-7

7. Riha RL, Brander P, Vennelle M, McArdle N, Kerr SM, Anderson NH, Douglas NJ. Tumour necrosis factor-alpha (-308) gene polymorphism in obstructive sleep apnoea-hypopnoea syndrome. Eur Respir J. 2005 Oct;26(4):673-8

8. Teixeira VG, Faccenda JF, Douglas NJ. Functional status in patients with narcolepsy. Sleep Med. 2004 Sep;5(5):477-83

9. Wild MR, Engleman HM, Douglas NJ, Espie CA. Can psychological factors help us to determine adherence to CPAP? A prospective study. Eur Respir J. 2004 Sep;24(3):461-5

10. Vennelle M, Brander PE, Kingshott RN, Rees K, Warren PM, Keeling JW, Douglas NJ. Is there a familial association between obstructive sleep apnoea/hypopnoea and the sudden infant death syndrome? Thorax. 2004 Apr;59(4):337-41

11. McArdle N, Riha RL, Vennelle M, Coleman EL, Dennis MS, Warlow CP, Douglas NJ. Sleep-disordered breathing as a risk factor for cerebrovascular disease: a case-control study in patients with transient ischemic attacks. Stroke. 2003 Dec;34(12):2916-21

12. Dingli K, Coleman EL, Vennelle M, Finch SP, Wraith PK, Mackay TW, Douglas NJ. Evaluation of a portable device for diagnosing the sleep apnoea/hypopnoea syndrome. Eur Respir J. 2003 Feb;21(2):253-9

13. Izci B, Riha RL, Martin SE, Vennelle M, Liston WA, Dundas KC, Calder AA, Douglas NJ. The upper airway in pregnancy and pre-eclampsia. Am J Respir Crit Care Med. 2003 Jan 15;167 (2):137-40

14. Massie CA, McArdle N, Hart RW, Schmidt-Nowara WW, Lankford A, Hudgel DW, Gordon N, Douglas NJ. Comparison between automatic and fixed positive airway pressure therapy in the home. Am J Respir Crit Care Med. 2003 Jan 1;167(1):20-3

15. Dingli K, Fietze I, Assimakopoulos T, Quispe-Bravo S, Witt C, Douglas NJ. Arousability in sleep apnoea/hypopnoea syndrome patients. Eur Respir J. 2002 Sep;20(3):733-40

16. Engleman HM, McDonald JP, Graham D, Lello GE, Kingshott RN, Coleman EL, Mackay TW, Douglas NJ. Randomized crossover trial of two treatments for sleep apnea/hypopnea syndrome: continuous positive airway pressure and mandibular
repositioning splint. Am J Respir Crit Care Med. 2002 Sep 15;166(6):855-9

17. Kelly CA, Newby DE, McDonagh TA, Mackay TW, Barr J, Boon NA, Dargie HJ, Douglas NJ. Randomised controlled trial of continuous positive airway pressure and standard oxygen therapy in acute pulmonary oedema; effects on plasma brain natriuretic peptide concentrations. Eur Heart J. 2002 Sep;23(17):1379-86

18. McArdle N, Douglas NJ. Effect of continuous positive airway pressure on sleep architecture in the sleep apnea-hypopnea syndrome: a randomized controlled trial. Am J Respir Crit Care Med. 2001 Oct 15;164(8 Pt 1):1459-63

19. Kingshott RN, Vennelle M, Coleman EL, Engleman HM, Mackay TW, Douglas NJ. Randomized, double-blind, placebo-controlled crossover trial of modafinil in the treatment of residual excessive daytime sleepiness in the sleep apnea/hypopnea syndrome. Am J Respir Crit Care Med. 2001 Mar;163(4):918-23

20. Thurnheer R, Wraith PK, Douglas NJ. Influence of age and gender on upper airway resistance in NREM and REM sleep. J Appl Physiol. 2001 Mar;90(3):981-8

21. Faccenda JF, Mackay TW, Boon NA, Douglas NJ. Randomized placebo-controlled trial of continuous positive airway pressure on blood pressure in the sleep apnea-hypopnea syndrome. Am J Respir Crit Care Med. 2001 Feb;163(2):344-8

22. Engleman HM, Kingshott RN, Martin SE, Douglas NJ. Cognitive function in the sleep apnea/hypopnea syndrome (SAHS). Sleep. 2000 Jun 15;23 Suppl 4:S102-8

Current/Completed Grants (past 5 years) CSO Scotland Grant (2010-2012) £210,130
Randomised Controlled Prospective Trial of the Effectiveness of Continuous Positive Airway Pressure Therapy in Adults with Down syndrome

MRC-HTA Multicentre Trial (2009-2012) £1.5 million
PREDICT: Positive airways pREssure in older people: a ranDomIsed Controlled Trial

Le Jeune Foundation Grant (2009-2011) €30,000
Prevalence of sleep disordered breathing in adults with Down Syndrome; effectiveness of therapy with continuous positive airway pressure

British Heart Foundation Research Grant (2007-2009) £162,200
Aortic distensibility in the obstructive sleep apnoea syndrome using cardiovascular MRI and pulse wave analysis: effect of CPAP therapy

RESMED LTD. (2005-2008) £142,559
Randomised controlled trial of variable-pressure versus fixed-pressure continuous positive airway pressure (CPAP) treatment for patients with obstructive sleep apnoea/hypopnoea syndrome

ERS School Educational Research Grant (2002-2003) CHF 15,000
Web-author of sleep education site for the ERS

British Heart Foundation Research Grant (2002-2005) £115, 709
Vascular responses and endothelial function in the obstructive

 
Other laboratory Members
 
First Name Donna Last Name Fairley RN Position Research Nurse E-Mail Donna.Fairley@ed.ac.uk  
Title BSc First Name Lizzie Last Name Hill BSc (Hons), RPSGT Position Research Fellow E-Mail Lizzie.Hill@ed.ac.uk  
First Name Marjorie Last Name Vennelle RGN, RPSGT Position Senior Research Manager E-Mail m.vennelle@ed.ac.uk  
Title PhD First Name Neil Middle Name J Last Name Douglas Position Professor of Respiratory Medicine E-Mail n.j.douglas@ed.ac.uk  
Collaborations
 
First Name Rebecca Last Name Reynolds Institution University of Edinburgh  
First Name Shona Last Name Kerr Institution WTCRF  
First Name John Last Name Stradling Institution Oxford Centre for Respiratory Medicine  
 
First Name Ludger Last Name Grove Institution ESADA  
First Name Mary Last Name Morrell Institution Imperial College London  
Past Members