European Sleep Research Laboratories

Sleep Disorders Unit, Dept of Thoracic Medicine, U

Medical School/ University of Crete, Greece
Thoracic Medicine/ Medical School


Sophia E Schiza
Voutes/1352
71110 Heraklion, Crete Greece


Position Assistant Professor of Thoracic Medicine Phone +30 2810 392433 Fax +30 2810 542650 Contact E-Mail schiza@med.uoc.gr   Research Domain
  • Clinical
  • Basic Human

Keywords
  • Molecular Biology-Endocrinology-Biochemistry
  • Sleep and Medical Disorders
  • Epidemiology of Sleep

Laboratory Description Domain research areas are: a)cardiological consequences of sleep breathing disorders (oxidative stress, endothelial dysfunction, inflamation), b) erectile dysfunction in patients with sleep breathing disorders, c) mechanisms affecting sleep in patients hospitalized in Acute Coronary Units, d) influence of sex and aging in diagnosis, natural history and in the cardiological consequences in patients with sleep breathing disorders, e) the role of Mediterranean diet and exercise as an adjuntive therapy in sleep apnea patients, particulary in inflamatory response, f) idiopathic fibrosis and sleep apnea, incidence, pathogenetic mechanisms and treatment adherence
Technical Capabilities and areas of expertise Six full PSG, 2 portable, 2 EtCO2, 4 oximeters, 1 NPT
Full time operating CPAP Clinic
In conjuction with our Molecular Biology departement we perform inflamatory markers analysis, PCR as well as mRNA extraction

Selected Publications in the 5 past years 1.Effect of Mediterranean diet on lipid peroxidation marker TBARS in obese patients with OSAHS under CPAP treatment: a randomised trial.Papandreou C, Schiza SE, Tzatzarakis MN, Kavalakis M, Hatzis CM, Tsatsakis AM, Kafatos AG, Siafakas NM, Tzanakis NE. Sleep Breath. 2011 Sep 15
2.CRP evolution pattern in CPAP-treated obstructive sleep apnea patients. Does gender play a role? Mermigkis D, Kallergis E, Mavroudi E, Varouchakis G, Tzortzaki E, Siafakas N, Schiza SE. Sleep Breath. 2011 Sep 1
3.C-reactive protein evolution in obstructive sleep apnoea patients under CPAP therapy.Schiza SE, Mermigkis C, Panagiotis P, Bouloukaki I, Kallergis E, Tzanakis N, Tzortzaki E, Vlachaki E, Siafakas NM. Eur J Clin Invest. 2010 Nov;40(11):968-75
4.Evidence of dysregulated affect indicated by high alexithymia in obstructive sleep apnea. Nikolaou A, Schiza SE, Chatzi L, Koudas V, Fokos S, Solidaki E, Bitsios P. J Sleep Res. 2011 Mar;20(1 Pt 1):92-100

5.Sleep patterns in patients with acute coronary syndromes.
Schiza SE, Simantirakis E, Bouloukaki I, Mermigkis C, Arfanakis D, Chrysostomakis S, Chlouverakis G, Kallergis EM, Vardas P, Siafakas NM.Sleep Med. 2010 Feb;11(2):149-53
6.Sleep-disordered breathing in heart failure and the effect of cardiac resynchronization therapy. Simantirakis EN, Schiza SE, Siafakas NS, Vardas PE. Europace. 2008 Sep;10(9):1029-33
7.Prediction of obstructive sleep apnea syndrome in a large Greek population. Bouloukaki I, Kapsimalis F, Mermigkis C, Kryger M, Tzanakis N, Panagou P, Moniaki V, Vlachaki EM, Varouchakis G, Siafakas NM, Schiza SE. Sleep Breath. 2010 Sep 25
8.Gluteal adipose-tissue polyunsaturated fatty-acids profiles and depressive symptoms in obese adults with obstructive sleep apnea hypopnea syndrome: a cross-sectional study.Papandreou C, Schiza SE, Tsibinos G, Mermigkis C, Hatzis CM, Kafatos AG, Siafakas NM, Fragkiadakis GA, Tzanakis NE. Pharmacol Biochem Behav. 2011 Apr;98(2):316-9
9. Utility of formulas predicting the optimal nasal continuous positive airway pressure in a Greek population. Schiza SE, Bouloukaki I, Mermigkis C, Panagou P, Tzanakis N, Moniaki V, Tzortzaki E, Siafakas NM. Sleep Breath. 2011 Sep;15(3):417-23
10. The 5-min pupillary alertness test is sensitive to modafinil: a placebo controlled study in patients with sleep apnea.
Nikolaou A, Schiza SE, Giakoumaki SG, Roussos P, Siafakas N, Bitsios P. Psychopharmacology (Berl). 2008 Feb;196(2):167-75
11. Atrial overdrive pacing for the obstructive sleep apnea-hypopnea syndrome. Simantirakis EN, Schiza SE, Chrysostomakis SI, Chlouverakis GI, Klapsinos NC, Siafakas NM, Vardas PE. N Engl J Med. 2005 Dec 15;353(24):2568-77
12. CPAP treatment in patients with idiopathic pulmonary fibrosis and obstructive sleep apnea-therapeutic difficulties and dilemmas.
Mermigkis C, Mermigkis D, Varouchakis G, Schiza S.
Sleep Breath. 2011 Jan 9

Key Publications of the Laboratory 1. Atrial overdrive pacing for the obstructive sleep apnea-hypopnea syndrome. Simantirakis EN, Schiza SE, Chrysostomakis SI, Chlouverakis GI, Klapsinos NC, Siafakas NM, Vardas PE. N Engl J Med. 2005 Dec 15;353(24):2568-77
2. C-reactive protein evolution in obstructive sleep apnoea patients under CPAP therapy.Schiza SE, Mermigkis C, Panagiotis P, Bouloukaki I, Kallergis E, Tzanakis N, Tzortzaki E, Vlachaki E, Siafakas NM. Eur J Clin Invest. 2010 Nov;40(11):968-75
3. Evidence of dysregulated affect indicated by high alexithymia in obstructive sleep apnea. Nikolaou A, Schiza SE, Chatzi L, Koudas V, Fokos S, Solidaki E, Bitsios P.
J Sleep Res. 2011 Mar;20(1 Pt 1):92-100
4. Utility of formulas predicting the optimal nasal continuous positive airway pressure in a Greek population.
Schiza SE, Bouloukaki I, Mermigkis C, Panagou P, Tzanakis N, Moniaki V, Tzortzaki E, Siafakas NM. Sleep Breath. 2011 Sep;15(3):417-23
5.Pupil miosis within 5 minutes in darkness is a valid and sensitive quantitative measure of alertness: application in daytime sleepiness associated with sleep apnea. Bitsios P, Schiza SE, Giakoumaki SG, Savidou K, Alegakis AK, Siafakas N. Sleep. 2006 Nov;29(11):1482-8
6. Sleep patterns in patients with acute coronary syndromes.
Schiza SE, Simantirakis E, Bouloukaki I, Mermigkis C, Arfanakis D, Chrysostomakis S, Chlouverakis G, Kallergis EM, Vardas P, Siafakas NM. Sleep Med. 2010 Feb;11(2):149-53
7. Prediction of obstructive sleep apnea syndrome in a large Greek population. Bouloukaki I, Kapsimalis F, Mermigkis C, Kryger M, Tzanakis N, Panagou P, Moniaki V, Vlachaki EM, Varouchakis G, Siafakas NM, Schiza SE. Sleep Breath. 2010 Sep 25
8. Severe bradyarrhythmias in patients with sleep apnoea: the effect of continuous positive airway pressure treatment: a long-term evaluation using an insertable loop recorder. Simantirakis EN, Schiza SI, Marketou ME, Chrysostomakis SI, Chlouverakis GI, Klapsinos NC, Siafakas NS, Vardas PE. Eur Heart J. 2004 Jun;25(12):1070-6
9. Effect of Mediterranean diet on lipid peroxidation marker TBARS in obese patients with OSAHS under CPAP treatment: a randomised trial. Papandreou C, Schiza SE, Tzatzarakis MN, Kavalakis M, Hatzis CM, Tsatsakis AM, Kafatos AG, Siafakas NM, Tzanakis NE. Sleep Breath. 2011 Sep 15
10. CRP evolution pattern in CPAP-treated obstructive sleep apnea patients. Does gender play a role? Mermigkis C, Bouloukaki I, Mermigkis D, Kallergis E, Mavroudi E, Varouchakis G, Tzortzaki E, Siafakas N, Schiza SE. Sleep Breath. 2011 Sep 1

 
Other laboratory Members
 
Title BSc First Name Dimitrios Last Name Manios Position Sleep Technician E-Mail bageraman@yahoo.gr  
Title BSc First Name Eleni Last Name Mauroudi Position Sleep Technician E-Mail elenima23@hotmail.com  
Title BSc First Name Violeta Last Name Moniaki Position Sleep Technician E-Mail vmoniaki@yahoo.gr  
Title PhD,MD First Name Izolthi Last Name Bouloukaki Position Consultant E-Mail izolthi@gmail.com  
Title BSc First Name Ioanna Last Name Fanouraki Position Sleep Technician E-Mail gianna@gmail.com  
Title PhD,MD First Name Nikolaos Middle Name M Last Name Siafakas Position Professor of Thoracic Medicine, Head of Dept of Thoracic Medicine E-Mail pneumon@med.uoc.r  
Collaborations
 
Title PhD,MD First Name Nikos Last Name Tzanakis Position Associate Professore of Epidemiology Institution Medical School, University of Crete, Greece  
Title PhD,MD First Name Eleni Last Name Tzortzaki Position Assistant Professor of Thoracic Medicine Institution Dept of Molecular Biology, dept of Thoracic Medicine, University of Crete, Greece  
Title PhD,MD First Name Eleutherios Middle Name M Last Name Kallergis Position Consultant of Cardiology and Arrythiology Dept Institution Cardiology Departement, University Hospital of Heraklion, Crete, Greece  
Title PhD,MD First Name Emmanuel Last Name Simantirakis Position Assistant Professor of Cardiology Institution Cardiology dept, University Hospital of Heraclion, Crete, Greece  
Title PhD,MD First Name Charalampos Last Name Mermigkis Position Head of Sleep Disorders Unit Institution 401 Military Hospital, Athens  
Past Members
 
Title PhD,MD First Name Elina Last Name Vlachaki Position Consultant E-Mail elina@otenet.gr