European Sleep Research Laboratories

Human Sleep Psychopharmacology Laboratory

University of Zürich
Institute of Pharmacology and Toxicology


Hans-Peter Landolt
Winterthurerstrasse 190
8057 Zürich Switzerland


Position Senior Researcher Phone +41 44 635 59 53 Fax +41 44 635 57 07 Contact E-Mail landolt@pharma.uzh.ch Website http://www.pharma.uzh.ch/research/chronobiology/areas/psychopharmacology.html   Research Domain
  • Basic Human
  • Clinical

Keywords
  • Sleep Physiology-Neurophysiology in Human
  • Sleep and Ageing
  • Pharmacology of Sleep
  • Genetics of Sleep
  • Sleep and Medical Disorders
  • Pharmacology – Human

Laboratory Description We are interested in the molecular mechanisms underlying individual differences in sleep, waking performance and response to sleep and wake promoting pharmacological agents in humans. To elucidate such mechanisms in health and disease, we combine and integrate methods of human genetics, selective pharmacology, multi-channel EEG, neuropsychological/cognitive testing and molecular brain imaging.
Selected Publications in the 5 past years - Valomon A, Holst SC, Bachmann V, Viola AU, Schmidt C, Zürcher J, Berger W, Cajochen C, and Landolt HP. Genetic polymorphisms of DAT1 and COMT differently affect actigraphy-derived sleep-wake cylces in humans. Chronobiol Int, in press.

- Holst SC, Bersagliere A, Bachmann V, Berger W, Achermann P, and Landolt HP. Dopaminergic role in regulating neurophysiological markers of sleep homeostasis in humans. J Neurosci 34, 566-573, 2014.

- Bosch OG, Rihm JS, Scheidegger M, Landolt HP, Stämpfli P, Brakowski J, Esposito F, Rasch B, and Seifritz E. Sleep deprivation increases dorsal nexus connectivity to the dorsolateral prefrontal cortex in humans. Proc Natl Acad Sci USA 110, 19597-15602, 2013.

- Hefti K, Holst SC, Sovago J, Bachmann V, Buck A, Ametamey SM, Scheidegger M, Bethold T, Gomez-Mancilla B, Seifritz E, and Landolt HP. Increased metabotropic glutamate receptor subtype 5 availability in human brain after one night without sleep. Biol Psychiatry 73, 161-168, 2013.

- Bachmann V, Klaus F, Bodenmann S, Schäfer N, Brugger P, Huber S, Berger W, and Landolt HP. Functional ADA polymorphism increases sleep depth and reduces vigilant attention in humans. Cereb Cortex 22, 962-970, 2012.

- Bachmann V, Klein C, Bodenmann S, Schäfer N, Berger W, Brugger P, and Landolt HP. The BDNF Val66Met polymorphism modulates sleep intensity: EEG frequency- and state-specificity. Sleep 35, 335-344, 2012.

- Bodenmann S, Hohoff C, Freitag C, Deckert J, Rétey JV, Bachmann V, and Landolt HP. Polymorphisms of ADORA2A modulate psychomotor vigilance and the effects of caffeine on neurobehavioral performance and sleep EEG after sleep deprivation. Br J Pharmacol 165, 1904-1913, 2012.

- Bodenmann S, Xu S, Luhmann UFO, Arand M, Berger W, Jung HH and Landolt HP (2009). Pharmacogenetics of modafinil after sleep loss: Catechol-O-Methyltransferase genotype modulates waking functions but not recovery sleep. Clin Pharmacol Ther 85, 296-304.

- Bodenmann S, Rusterholz T, Dürr R, Stoll C, Bachmann V, Geissler E, Jaggi-Schwarz K and Landolt HP (2009). The functional Val158Met polymorphism of COMT predicts individual differences in brain alpha oscillations. J Neurosci 29, 10855-10862.

Key Publications of the Laboratory - Holst SC, Bersagliere A, Bachmann V, Berger W, Achermann P, and Landolt HP. Dopaminergic role in regulating neurophysiological markers of sleep homeostasis in humans. J Neurosci 34, 566-573, 2014.

- Hefti K, Holst SC, Sovago J, Bachmann V, Buck A, Ametamey SM, Scheidegger M, Bethold T, Gomez-Mancilla B, Seifritz E, and Landolt HP. Increased metabotropic glutamate receptor subtype 5 availability in human brain after one night without sleep. Biol Psychiatry 73, 161-168, 2013.

- Bachmann V, Klaus F, Bodenmann S, Schäfer N, Brugger P, Huber S, Berger W, and Landolt HP. Functional ADA polymorphism increases sleep depth and reduces vigilant attention in humans. Cereb Cortex 22, 962-970, 2012.

- Rétey JV, Adam M, Khatami R, Luhmann UFO, Jung HH, Berger W, and Landolt HP. A genetic variation on the adenosine A2A receptor gene (ADORA2A) contributes to individual sensitivity to caffeine effects on sleep. Clin Pharmacol Ther 81, 692-698, 2007.

- Rétey JV, Adam M, Honegger E, Khatami R, Luhmann U, Jung HH, Berger W and Landolt HP (2005). A functional genetic variation of adenosine deaminase affects the duration and intensity of deep sleep in humans. Proc Natl Acad Sci USA 102, 15676-15681.

Current/Completed Grants (past 5 years) - Swiss National Science Foundation # 320030-135414:
“Glutamatergic mechanisms in sleep-wake homeostasis in health and disease – molecular brain imaging and pharmacogenetics”

- Zürich Center for Integrative Human Physiology (ZIHP):
“Inhibiting COMT - Neuroprotection and wake-promotion?”

- University of Zürich:
Clinical Research Priority Program “Sleep and Health”

 
Other laboratory Members
 
Title PhD First Name Sebastian Middle Name Camillo Last Name Holst Position Postdoctoral fellow E-Mail holst@pharma.uzh.ch  
Title MSc First Name Emily Last Name Urry Position PhD student E-Mail emily.urry@pharma.uzh.ch  
Title MSc First Name Amandine Last Name Valomon Position PhD student E-Mail avalomon@yahoo.fr  
Title MSc First Name Alexandra Last Name Sousek Position PhD Student E-Mail alexandra.sousek@pharma.uzh.ch  
Title MSc First Name Susanne Last Name Münzing Position PhD Student E-Mail susanne.muenzing@pharma.uzh.ch  
Title BSc First Name Darya Last Name Erkhova Position Scientific assistant E-Mail derkhova@gmail.com  
Title BSc First Name Ian Last Name Clark Position Scientific assistant E-Mail Ian.Clark@uzh.ch  
Collaborations
 
Title PhD First Name Peter Last Name Brugger Institution Department of Neurology, University Hospital, Zürich, Switzerland  
Title MD First Name Erich Last Name Seifritz Institution Clinic of Affective Disorders and General Psychiatry, Psychiatric University Hospital, Zürich, Switzerland  
Title MD First Name Christian Last Name Baumann Institution Department of Neurology, University Hospital, Zürich, Switzerland  
Title PhD First Name Wolfgang Last Name Berger Institution Institute of Medical Molecular Genetics, University of Zürich, Schwerzenbach, Switzerland  
Title PhD First Name Christian Last Name Cajochen Institution Centre for Chronobiology, Psychiatric Hospital of the University of Basel, Basel, Switzerland  
Past Members
 
Title PhD First Name Katharina Last Name Hefti Position PhD student E-Mail katharina.hefti@pharma.uzh.ch  
Title PhD First Name Valérie Last Name Bachmann Position PhD student E-Mail valerie.bachmann@gmail.com  
Title PhD First Name Sereina Last Name Bodenmann Position PhD student E-Mail sereina@gmx.net  
Title PhD First Name Eva Last Name Geissler Position PhD student E-Mail eva.geissler@pharma.ethz.ch  
Title PhD First Name Julia Last Name Rétey E-Mail jretey@gmx.ch