European Sleep Research Laboratories

Sleep Disorders Unit

Medical University Innsbruck
University Hospital of Neurology

MD
Birgit Högl
Anichstraße 35
6020 Innsbruck Austria


Position Head of Laboratory Phone +43 512 504 23811 Fax +43 512 504 23842 Contact E-Mail birgit.ho@i-med.ac.at Website http://www.i-med.ac.at/neurologie/forschung/schlaf.html   Research Domain
  • Clinical
  • Basic Human

Keywords
  • Others
  • Sleep and Medical Disorders
  • Genetics of Sleep
  • Neurological Sleep Disorders

Laboratory Description The sleep disorders clinic at the Department of Neurology of Innsbruck Medical University serves as a tertiary sleep disorders referral center serving for a population of about 2 million from western Austria and South Tyrol (Northern Italy). It is the only academic facility for diagnosis and treatment of sleep disorders in the abovementioned area. It offers specialized diagnosis and treatment for the full range of disorders of sleep and wakefulness and serves as specialized referral center for difficult clinical cases for selected patients from all over Austria.

Birgit Högl MD is a senior neurologist and board certified sleep specialist and head of the sleep disorders unit and sleep research group since 1999. She is President of the European Restless Legs Study Group (EURLSSG), treasurer of the World Association of Sleep Medicine (WASM), secretary of the International Restless Legs Study Group (IRLSSG), past president o the Austrian sleep research association (ÖGSM/ASRA), Chair of the Publication Committee of the WASM, Chair of The Movement Disorders in Sleep Section of the American Academy of Sleep Medicine (AASM).

The medical staff of the Innsbruck sleep research group further consists of senior neurologist Priv Doz. Birgit Frauscher MD, senior neurologist and board certified sleep specialist Elisabeth Brandauer MD, two residents Viola Gschliesser MD and Laura Ehrmann MD and two PhD students, Thomas Mitterling MD and David Gabelia MD. The center’s main research topics are daytime sleepiness and motor phenomena during sleep in health and disease. In the field of idiopathic hypersomnia and narcolepsy, research is aimed on epidemiology, genetics, pathophysiology and treatment. Regarding sleep related movement disorders, notably Restless Legs Syndrome (RLS) the Innsbruck sleep research group conducted numerous studies on epidemiology, genetics, treatment and establishment of rating scales. Another research field is neuropsychology and sleep disorders. Together with cooperation partners new polysomnographic montages have been developed, and established for diagnosis of REM-Sleep Behavior Disorder (RBD) and studies on normative values of REM sleep without atonia were performed. Multiple long-standing international collaborations in this field exist highlightening ongoing genetic collaborations and a European bicentric collaboration with the Department of Neurology, Hospital Clinic de Barcelona (SINBAR collaboration: A. Iranzo, J. Santamaria, E. Tolosa).

The sleep group of Innsbruck has been organizer of national and international congresses (ASRA 2003 and 2010, ESRS 2006, WASM teaching course 2011) and is involved in training of junior researchers and residents. Furthermore it was home for guest visiting professors and guest fellows from Argentina, Armenia, Brazil, Italy, Georgia, Germany, Japan, Netherlands, and Thailand.

Technical Capabilities and areas of expertise Chief technician is Heinz Hackner a board certified somnologist. The sleep disorders clinic has a 6 bed sleep laboratory with state of the art polysomnography (PSG) equipment. All types of PSG with recording of up to 65 channels and MSLT MWT are performed. Additionally it offers sleep apnea screening (4 devices) and actigraphy.
Selected Publications in the 5 past years Oertel W, Trenkwalder C, Beneš H, Ferini-Strambi L, Högl B, Poewe W, Stiasny-Kolster K, Fichtner A, Schollmayer E, Kohnen R, García-Borreguero D, on behalf of the SP710 study group. Long-term safety and efficacy of rotigotine transdermal patch for moderate-to-severe idiopathic restless legs syndrome: a 5-year open-label extension study. Lancet Neurol. 2011; 10:710-720

Winkelmann J, Czamara D, Schormair B, Knauf F, Schulte E, Trenkwalder C, Dauvilliers Y, Polo O, Högl B, Berger K, Fuhs A, Gross N, Stiasny-Kolster K, Oertel W, Bachmann C, Paulus W, Xiong L, Montplaisir J, Rouleau G, Fietze I, Vávrová J, Kemlink D, Sonka K, Nevsimalova S, Lin S, Wszolek Z, Vilarino-Guell C, Farrer M,Gschliesser V, Frauscher B, Falkenstetter T, Poewe W, Allen RP, Ealey Ch, Ondo WG, Le W, Spieler D, Kaffe M, Zimprich A, Kettunen J, Perola M, Silander K, Cournu-Rebeix I, Francavilla M, Fontenille C, Fontaine B, Vodicka P, Prokisch H, Lichtner P, Peppard P, Mignot E, Faraco J, Gieger CH, Illig Th, Wichmann HE, Müller-Myhsok B, Meitinger Th. Genome-wide association study identifies novel Restless Legs Syndrome susceptibility loci on 1p 14 and 16q12.1. PLoS Genetics 2011;7:e1002171

Nomura R, Inoue Y, Högl B, Uemura Y, Yasui K, Sasai T, Namba K, Nakashima K. Comparison of the clinical features of rapid eye movement sleep behavior disorder in patients with Parkinsons’s disease and multiple system atrophy. Psychiatry Clin Neurosci. 2011;65:264-271

Delazer M, Högl B, Zamarian L, Wenter J, Gschliesser V, Ehrmann L, Brandauer E, Cevikkol Z, Frauscher B. Executive functions, information sampling, and decision making in narcolepsy with cataplexy. Neuropsychology. 2011 ;25:477-487

Frauscher B, Hering S, Högl B, Gschliesser V, Ulmer H, Poewe W, Boesch SM. Restless legs syndrome in Friedreich ataxia: A polysomnographic study. Mov Disord. 2011;26:302-6.

Scherfler C, Frauscher B, Schocke M, Iranzo A, Gschliesser V, Seppi K, Santamaria J, Tolosa E, Högl B, Poewe W; for the SINBAR (Sleep Innsbruck Barcelona) Group. White and gray matter abnormalities in idiopathic rapid eye movement sleep behavior disorder: A diffusion-tensor imaging and voxel-based morphometry study. Ann Neurol. 2011;69:400-407

Högl B, Gschliesser V, Poewe W. Assessing treatment outcome in RLS trials and clinical care: CGI-I, PGI, or VAS? Sleep Med. 2011 Mar 3 [Epub ahead of print]

Högl B, Garcia-Borreguero D, Trenkwalder C, Ferini-Strambi L, Hening W, Poewe W, Brenner SS, Fraessdorf M, Busse M, Albrecht S, Allen RP. Efficacy and augmentation during 6months of double-blind pramipexole for restless legs syndrome. Sleep Med. 2011;12:351-60

Garcia-Borreguero D, Stillman P, Benes H, Buschmann H, Chaudhuri KR, Gonzalez Rodríguez VM, Högl B, Kohnen R, Monti GC, Stiasny-Kolster K, Trenkwalder C, Williams AM, Zucconi M. Algorithms for the diagnosis and treatment of restless legs syndrome in primary care. BMC Neurol. 2011;11:28.

Iranzo A, Frauscher B, Santos H, Gschliesser V, Ratti L, Falkenstetter T, Stürner C, Salamero M, Tolosa E, Poewe W, Santamaria J, Högl B; for the SINBAR (Sleep Innsbruck Barcelona) Group. Usefulness of the SINBAR electromyographic montage to detect the motor and vocal manifestations occurring in REM sleep behavior disorder. Sleep Med. 2011 ;12:284-288

Frauscher B, Kunz A, Brandauer E, Ulmer H, Poewe W, Högl B. Fragmentary myoclonus in sleep revisited: A polysomnographic study in 62 patients. Sleep Med. 2011 ;12:410-415

Trenkwalder C, Kohnen R, Högl B, Metta V, Sixel-Döring F, Frauscher B, Hülsmann J, Martinez-Martin P, Chaudhuri KR. Parkinson's disease sleep scale-validation of the revised version PDSS-2. Mov Disord. 2011; 26:644-52

Nomura T, Nakashima K, Inoue Y, Högl B. Authors' reply to the comments of Miyamoto et al. regarding "Cardiac (123)I-MIBG accumulation in Parkinson's disease differs in association with REM sleep behavior disorder". Parkinsonism Relat Disord. 2011. [Epub ahead of print] No abstract available.

Frauscher B, Gschliesser V, Brandauer E, Schönwald SV, Falkenstetter T, Ehrmann L, Tokmak I, Poewe W, Högl B. Motor disturbances during non-REM and REM sleep in narcolepsy-cataplexy: a video-polysomnographic analysis. J Sleep Res. 2011 Jan 25. doi: 10.1111/j.1365-2869.2011.00906.x. [Epub ahead of print]

Scherfler C, Frauscher B, Schocke M, Iranzo A, Gschliesser V, Seppi K, Santamaria J, Tolosa E, Högl B, Poewe W; for the SINBAR (Sleep Innsbruck Barcelona) Group. White and gray matter abnormalities in idiopathic rapid eye movement sleep behavior disorder: A diffusion-tensor imaging and voxel-based morphometry study. Ann Neurol. 2010 Dec 28. [Epub ahead of print]

Kornum BR, Kawashima M, Faraco J, Lin L, Rico TJ, Hesselson S, Axtell RC, Kuipers H, Weiner K, Hamacher A, Kassack MU, Han F, Knudsen S, Li J, Dong X, Winkelmann J, Plazzi G, Nevsimalova S, Hong SC, Honda Y, Honda M, Högl B, Ton TG, Montplaisir J, Bourgin P, Kemlink D, Huang YS, Warby S, Einen M, Eshragh JL, Miyagawa T, Desautels A, Ruppert E, Hesla PE, Poli F, Pizza F, Frauscher B, Jeong JH, Lee SP, Strohl KP, Longstreth WT Jr, Kvale M, Dobrovolna M, Ohayon MM, Nepom GT, Wichmann HE, Rouleau GA, Gieger C, Levinson DF, Gejman PV, Meitinger T, Peppard P, Young T, Jennum P, Steinman L, Tokunaga K, Kwok PY, Risch N, Hallmayer J, Mignot E. Common variants in P2RY11 are associated with narcolepsy. Nat Genet. 2011;43(1):66-71

Frauscher B, Hering S, Högl B, Gschliesser V, Ulmer H, Poewe W, Boesch SM. Restless legs syndrome in Friedreich ataxia: A polysomnographic study. Mov Disord. 2010 Dec 13. [Epub ahead of print]

Gradinger F, Boldt C, Högl B, Cieza A. Part 2. Identification of problems in functioning of persons with sleep disorders from the health professional perspective using the International Classification of Functioning, Disability and Health (ICF) as a reference: A worldwide expert survey. Sleep Med. 2011; 12:97-101.

Högl B, Arnulf I, Comella C, Ferreira J, Iranzo A, Tilley B, Trenkwalder C, Poewe W, Rascol O, Sampaio C, Stebbins GT, Schrag A, Goetz CG. Scales to assess sleep impairment in Parkinson's disease: Critique and recommendations. Mov Disord 2010;25:2704-16

Högl B, Oertel WH, Stiasny-Kolster K, Geisler P, Beneš H, García-Borreguero D, Trenkwalder C, Poewe W, Schollmayer E, Kohnen R. Treatment of moderate to severe restless legs syndrome: 2-year safety and efficacy of rotigotine transdermal patch. BMC Neurol 2010;10:86.

Högl B. Sleep apnea in Parkinson's disease: when is it significant? Sleep Med 2010;11:233-5.

Zeitlhofer J, Seidel S, Klösch G, Moser D, Anderer P, Saletu B, Bolitschek J, Popovic R, Lehofer M, Mallin W, Fugger B, Holzinger B, Kerbl R, Saletu A, Machatschke IH, Pavelka R, Högl B.
Sleep habits and sleep complaints in Austria: current self-reported data on sleep behaviour, sleep disturbances and their treatment. Acta Neurol Scand 2010;122(6):398-403

Nomura T, Inoue Y, Högl B, Uemura Y, Kitayama M, Abe T, Miyoshi H, Nakashima K. Relationship between (123)I-MIBG scintigrams and REM sleep behavior disorder in Parkinson's disease. Parkinsonism Relat Disord 2010;16:683-685

Frauscher B, Gschliesser V, Brandauer E, Marti I, Furtner MT, Ulmer H, Poewe W, Högl B. REM sleep behavior disorder in 703 sleep-disorder patients: the importance of eliciting a comprehensive sleep history. Sleep Med 2010;11:167-71.

Iranzo A, Lomeña F, Stockner H, Valldeoriola F, Vilaseca I, Salamero M, Molinuevo JL, Serradell M, Duch J, Pavía J, Gallego J, Seppi K, Högl B, Tolosa E, Poewe W, Santamaria J; for the Sleep Innsbruck Barcelona (SINBAR) group. Decreased striatal dopamine transporter uptake and substantia nigra hyperechogenicity as risk markers of synucleinopathy in patients with idiopathic rapid-eye-movement sleep behaviour disorder: a prospective study. Lancet Neurol 2010;9:1070-1077.

Oertel WH, Benes H, Garcia-Borreguero D, Högl B, Poewe W, Montagna P, Ferini-Strambi L, Sixel-Döring F, Trenkwalder C, Partinen M, Saletu B, Polo O, Fichtner A, Schollmayer E, Kohnen R, Cassel W, Penzel T, Stiasny-Kolster K. Rotigotine transdermal patch in moderate to severe idiopathic restless legs syndrome: a randomized, placebo-controlled polysomnographic study. Sleep Med 2010;11:848-56.

Garcia-Borreguero D, Allen R, Kohnen R, Benes H, Winkelman J, Högl B, Ferini-Strambi L, Zucconi M, Trenkwalder C. Loss of response during long-term treatment of restless legs syndrome: guidelines approved by the International Restless Legs Syndrome Study Group for use in clinical trials. Sleep Med 2010;11:956-7.

Frauscher B, Brandauer E, Gschliesser V, Falkenstetter T, Furtner MT, Ulmer H, Poewe W, Högl B. A descriptive analysis of neck myoclonus during routine polysomnography. Sleep 2010; 33:1091-6.

Lammers GJ, Bassetti C, Billiard M, Black J, Broughton R, Dauvilliers Y, Strambi LF, Garcia-Borreguero D, Goswami M, Högl B, Iranzo A, Jennum P, Khatami R, Lecendreux M, Mayer G, Mignot E, Montplaisir J, Nevsimalova S, Adrados RP, Plazzi G, Scammell T, Silber M, Sonka K, Tafti M, Thorpy M. Sodium oxybate is an effective and safe treatment for narcolepsy. Sleep Med 2010;11:105-6.

Högl B, García-Borreguero D, Kohnen R, Ferini-Strambi L, Hadjigeorgiou G, Hornyak M, de Weerd A, Happe S, Stiasny-Kolster K, Gschliesser V, Egatz R, Frauscher B, Benes H, Trenkwalder C, Hening WA, Allen RP. Progressive development of augmentation during long-term treatment with levodopa in restless legs syndrome: results of a prospective multi-center study. J Neurol 2010;257:230-7.

Frauscher B, Gschliesser V, Brandauer E, Marti I, Furtner M, Ulmer H, Poewe W, Högl B. REM sleep behavior disorder in 703 sleep-disorder patients: The importance of eliciting a comprehensive sleep history. Sleep Med 2010;11:167-171.

Tassinari CA, Cantalupo G, Högl B, Cortelli P, Tassi L, Francione S, Nobili L, Meletti S, Rubboli G, Gardella E. Neuroethological approach to frontolimbic epileptic seizures and parasomnias: The same central pattern generators for the same behaviours. Rev Neurol (Paris) 2009;165:762-8.

Peralta CM, Frauscher B, Seppi K, Wolf E, Wenning GK, Högl B, Poewe W. Restless legs syndrome in Parkinson's disease. Mov Disord 2009;24:2076-80.

Stockner H, Iranzo A, Seppi K, Serradell M, Gschliesser V, Sojer M, Valldeoriola F, Molinuevo JL, Frauscher B, Schmidauer C, Santamaria J, Högl B, Tolosa E, Poewe W; SINBAR (Sleep Innsbruck Barcelona) Group. Midbrain hyperechogenicity in idiopathic REM sleep behavior disorder. Mov Disord 2009;24:1906-9.

Trenkwalder C, Högl B, Winkelmann J. Recent advances in the diagnosis, genetics and treatment of restless legs syndrome. J Neurol 2009;256:539-53.

Hallmayer J, Faraco J, Lin L, Hesselson S, Winkelmann J, Kawashima M, Mayer G, Plazzi G, Nevsimalova S, Bourgin P, Hong SS, Honda Y, Honda M, Högl B, Longstreth WT Jr, Montplaisir J, Kemlink D, Einen M, Chen J, Musone SL, Akana M, Miyagawa T, Duan J, Desautels A, Erhardt C, Hesla PE, Poli F, Frauscher B, Jeong JH, Lee SP, Ton TG, Kvale M, Kolesar L, Dobrovolná M, Nepom GT, Salomon D, Wichmann HE, Rouleau GA, Gieger C, Levinson DF, Gejman PV, Meitinger T, Young T, Peppard P, Tokunaga K, Kwok PY, Risch N, Mignot E. Narcolepsy is strongly associated with the T-cell receptor alpha locus. Nat Genet 2009;41:708-11.

Högl B, Trenkwalder C, Poewe W. More on the restless legs syndrome and spinal anesthesia. N Engl J Med 2009;360:1155; author reply 1155-6.

Kemlink D, Polo O, Frauscher B, Gschliesser V, Högl B, Poewe W, Vodicka P, Vavrova J, Sonka K, Nevsimalova S, Schormair B, Lichtner P, Silander K, Peltonen L, Gieger C, Wichmann HE, Zimprich A, Roeske D, Müller-Myhsok B, Meitinger T, Winkelmann J. Replication of restless legs syndrome loci in three European populations. J Med Genet 2009;46:315-8.

Frauscher B, Gschliesser V, Brandauer E, El-Demerdash E, Kaneider M, Rücker L, Poewe W, Högl B. The severity range of restless legs syndrome (RLS) and augmentation in a prospective patient cohort: association with ferritin levels. Sleep Med 2009;10:611-5.

Furtner M, Staudacher M, Frauscher B, Brandauer E, Esnaola y Rojas MM, Gschliesser V, Poewe W, Schmidauer C, Ritsch-Marte M, Högl B. Cerebral vasoreactivity decreases overnight in severe obstructive sleep apnea syndrome: a study of cerebral hemodynamics. Sleep Med 2009;10:875-81.

Gschliesser V, Högl B, Frauscher B, Brandauer E, Poewe W, Luef G. Mode of vagus nerve stimulation differentially affects sleep related breathing in patients with epilepsy. Seizure 2009;18:339-42.

Ferri R, Gschliesser V, Frauscher B, Poewe W, Högl B. Periodic leg movements during sleep and periodic limb movement disorder in patients presenting with unexplained insomnia. Clin Neurophysiol 2009;120:257-63.

Gschliesser V, Frauscher B, Brandauer E, Kohnen R, Ulmer H, Poewe W, Högl B. PLM detection by actigraphy compared to polysomnography: a validation and comparison of two actigraphs. Sleep Med 2009;10:306-11.

Frauscher B, Gschliesser V, Brandauer E, Ulmer H, Poewe W, Högl B. The relation between abnormal behaviors and REM sleep microstructure in patients with REM sleep behavior disorder. Sleep Med 2009;10:174-81.


Oertel WH, Benes H, Garcia-Borreguero D, Geisler P, Högl B, Trenkwalder C, Tacken I, Schollmayer E, Kohnen R, Stiasny-Kolster K; Rotigotine SP710 Study Group. One year open-label safety and efficacy trial with rotigotine transdermal patch in moderate to severe idiopathic restless legs syndrome. Sleep Med 2008;9:865-73.

Schormair B, Kemlink D, Roeske D, Eckstein G, Xiong L, Lichtner P, Ripke S, Trenkwalder C, Zimprich A, Stiasny-Kolster K, Oertel W, Bachmann CG, Paulus W, Högl B, Frauscher B, Gschliesser V, Poewe W, Peglau I, Vodicka P, Vávrová J, Sonka K, Nevsimalova S, Montplaisir J, Turecki G, Rouleau G, Gieger C, Illig T, Wichmann HE, Holsboer F, Müller-Myhsok B, Meitinger T, Winkelmann J. PTPRD (protein tyrosine phosphatase receptor type delta) is associated with restless legs syndrome. Nat Genet 2008;40:946-8.

Frauscher B, Iranzo A, Högl B, Casanova-Molla J, Salamero M, Gschliesser V, Tolosa E, Poewe W, Santamaria J; SINBAR (Sleep Innsbruck Barcelona group). Quantification of electromyographic activity during REM sleep in multiple muscles in REM sleep behavior disorder. Sleep 2008;31:724-31.

Trenkwalder C, Benes H, Poewe W, Oertel WH, Garcia-Borreguero D, de Weerd AW, Ferini-Strambi L, Montagna P, Odin P, Stiasny-Kolster K, Högl B, Chaudhuri KR, Partinen M, Schollmayer E, Kohnen R; SP790 Study Group. Efficacy of rotigotine for treatment of moderate-to-severe restless legs syndrome: a randomised, double-blind, placebo-controlled trial. Lancet Neurol 2008;7:595-604.

Kemlink D, Plazzi G, Vetrugno R, Provini F, Polo O, Stiasny-Kolster K, Oertel W, Nevsimalova S, Sonka K, Högl B, Frauscher B, Hadjigeorgiou GM, Pramstaller PP, Lichtner P, Meitinger T, Müller-Myshok B, Winkelmann J, Montagna P. Suggestive evidence for linkage for restless legs syndrome on chromosome 19p13. Neurogenetics 2008;9:75-82.

Trenkwalder C, Högl B, Benes H, Kohnen R. Augmentation in restless legs syndrome is associated with low ferritin. Sleep Med 2008;9:572-4.

Oertel WH, Benes H, Garcia-Borreguero D, Geisler P, Högl B, Saletu B, Trenkwalder C, Sommerville KW, Schollmayer E, Kohnen R, Stiasny-Kolster K; Rotigotine SP 709 Study Group. Efficacy of rotigotine transdermal system in severe restless legs syndrome: a randomized, double-blind, placebo-controlled, six-week dose-finding trial in Europe. Sleep Med 2008;9:228-39.

Martinez-Rodriguez JE, Seppi K, Cardozo A, Iranzo A, Stampfer-Kountchev M, Wenning G, Tolosa E, Högl B, Santamaria J, Poewe W; SINBAR (Sleep Innsbruck Barcelona) group. Cerebrospinal fluid hypocretin-1 levels in multiple system atrophy. Mov Disord 2007;22:1822-4.

García-Borreguero D, Allen RP, Benes H, Earley C, Happe S, Högl B, Kohnen R, Paulus W, Rye D, Winkelmann J. Augmentation as a treatment complication of restless legs syndrome: concept and management. Mov Disord 2007;22 Suppl 18:S476-84.

Högl B, Gschliesser V. RLS assessment and sleep questionnaires in practice--lessons learned from Parkinson's disease. Sleep Med 2007;8 Suppl 2:S7-12.

Högl B. Periodic limb movements are associated with disturbed sleep. Pro. J Clin Sleep Med 2007;3:12-4.

Winkelmann J, Polo O, Provini F, Nevsimalova S, Kemlink D, Sonka K, Högl B, Poewe W, Stiasny-Kolster K, Oertel W, de Weerd A, Strambi LF, Zucconi M, Pramstaller PP, Arnulf I, Trenkwalder C, Klein C, Hadjigeorgiou GM, Happe S, Rye D, Montagna P. Genetics of restless legs syndrome (RLS): State-of-the-art and future directions. Mov Disord 2007;22 Suppl 18:S449-58.

García-Borreguero D, Allen RP, Kohnen R, Högl B, Trenkwalder C, Oertel W, Hening WA, Paulus W, Rye D, Walters A, Winkelmann J, Earley CJ; International Restless Legs Syndrome Study Group. Diagnostic standards for dopaminergic augmentation of restless legs syndrome: report from a World Association of Sleep Medicine-International Restless Legs Syndrome Study Group consensus conference at the Max Planck Institute. Sleep Med 2007;8:520-30.

Högl B, Zucconi M, Provini F. RLS, PLM, and their differential diagnosis - a video guide. Mov Disord 2007;22 Suppl 18:S414-9.

García-Borreguero D, Kohnen R, Högl B, Ferini-Strambi L, Hadjigeorgiou GM, Hornyak M, de Weerd AW, Happe S, Stiasny-Kolster K, Gschliesser V, Egatz R, Cabrero B, Frauscher B, Trenkwalder C, Hening WA, Allen RP. Validation of the Augmentation Severity Rating Scale (ASRS): a multicentric, prospective study with levodopa on restless legs syndrome. Sleep Med 2007;8:455-63.

Trenkwalder C, Kohnen R, Allen RP, Benes H, Ferini-Strambi L, Garcia-Borreguero D, Hadjigeorgiou GM, Happe S, Högl B, Hornyak M, Klein C, Nass A, Montagna P, Oertel WH, O'Keeffe S, Paulus W, Poewe W, Provini F, Pramstaller PP, Sieminski M, Sonka K, Stiasny-Kolster K, de Weerd A, Wetter TC, Winkelmann J, Zucconi M. Clinical trials in restless legs syndrome - recommendations of the European RLS Study Group (EURLSSG). Mov Disord 2007;22 Suppl 18:S495-504.

Frauscher B, Löscher W, Högl B, Poewe W, Kofler M. Auditory startle reaction is disinhibited in idiopathic restless legs syndrome. Sleep 2007;30:489-93.

Frauscher B, Gschliesser V, Brandauer E, Ulmer H, Peralta CM, Müller J, Poewe W, Högl B. Video analysis of motor events in REM sleep behavior disorder. Mov Disord 2007;22:1464-70.

Trenkwalder C, Benes H, Grote L, Happe S, Högl B, Mathis J, Saletu-Zyhlarz GM, Kohnen R; CALDIR Study Group. Cabergoline compared to levodopa in the treatment of patients with severe restless legs syndrome: results from a multi-center, randomized, active controlled trial. Mov Disord 2007;22:696-703.

Kemlink D, Polo O, Montagna P, Provini F, Stiasny-Kolster K, Oertel W, de Weerd A, Nevsimalova S, Sonka K, Högl B, Frauscher B, Poewe W, Trenkwalder C, Pramstaller PP, Ferini-Strambi L, Zucconi M, Konofal E, Arnulf I, Hadjigeorgiou GM, Happe S, Klein C, Hiller A, Lichtner P, Meitinger T, Müller-Myshok B, Winkelmann J. Family-based association study of the restless legs syndrome loci 2 and 3 in a European population. Mov Disord 2007;22:207-12.

Gatto EM, Uribe Roca MC, Martínez O, Valiensi S, Högl B. Rapid eye movement (REM) sleep without atonia in two patients with corticobasal degeneration (CBD). Parkinsonism Relat Disord 2007;13:130-2.

Högl B, Paulus W, Clarenbach P, Trenkwalder C. Restless legs syndrome: diagnostic assessment and the advantages and risks of dopaminergic treatment. J Neurol 2006;253 Suppl 4:IV22-8.

Boesch SM, Frauscher B, Brandauer E, Wenning GK, Poewe W, Högl B. Restless legs syndrome and motor activity during sleep in spinocerebellar ataxia type 6. Sleep Med 2006;7:529-32.

Boesch SM, Frauscher B, Brandauer E, Wenning GK, Högl B, Poewe W. Disturbance of rapid eye movement sleep in spinocerebellar ataxia type 2. Mov Disord 2006;21:1751-4.

Seppi K, Högl B, Diem A, Peralta C, Wenning GK, Poewe W. Levodopa-induced sleepiness in the Parkinson variant of multiple system atrophy. Mov Disord 2006;21:1281-3.

Gschliesser V, Brandauer E, Ulmer H, Poewe W, Högl B. Periodic limb movement counting in polysomnography: effects of amplitude. Sleep Med 2006;7:249-54.

Zucconi M, Ferri R, Allen R, Baier PC, Bruni O, Chokroverty S, Ferini-Strambi L, Fulda S, Garcia-Borreguero D, Hening WA, Hirshkowitz M, Högl B, Hornyak M, King M, Montagna P, Parrino L, Plazzi G, Terzano MG; International Restless Legs Syndrome Study Group (IRLSSG). The official World Association of Sleep Medicine (WASM) standards for recording and scoring periodic leg movements in sleep (PLMS) and wakefulness (PLMW) developed in collaboration with a task force from the International Restless Legs Syndrome Study Group (IRLSSG). Sleep Med 2006;7:175-83.

Högl B. Circadian rhythms in RLS. Sleep Med 2006;7:209-10.

Rissling I, Frauscher B, Kronenberg F, Tafti M, Stiasny-Kolster K, Robyr AC, Körner Y, Oertel WH, Poewe W, Högl B, Möller JC. Daytime sleepiness and the COMT val158met polymorphism in patients with Parkinson disease. Sleep 2006;29(1):108-11.

Key Publications of the Laboratory Frauscher B, Hering S, Högl B, Gschliesser V, Ulmer H, Poewe W, Boesch SM. Restless legs syndrome in Friedreich ataxia: A polysomnographic study. Mov Disord. 2011;26:302-6.

Iranzo A, Frauscher B, Santos H, Gschliesser V, Ratti L, Falkenstetter T, Stürner C, Salamero M, Tolosa E, Poewe W, Santamaria J, Högl B; for the SINBAR (Sleep Innsbruck Barcelona) Group. Usefulness of the SINBAR electromyographic montage to detect the motor and vocal manifestations occurring in REM sleep behavior disorder. Sleep Med. 2011 ;12:284-288

Frauscher B, Kunz A, Brandauer E, Ulmer H, Poewe W, Högl B. Fragmentary myoclonus in sleep revisited: A polysomnographic study in 62 patients. Sleep Med. 2011 ;12:410-415

Frauscher B, Gschliesser V, Brandauer E, Schönwald SV, Falkenstetter T, Ehrmann L, Tokmak I, Poewe W, Högl B. Motor disturbances during non-REM and REM sleep in narcolepsy-cataplexy: a video-polysomnographic analysis. J Sleep Res. 2011 Jan 25. doi: 10.1111/j.1365-2869.2011.00906.x. [Epub ahead of print]

Frauscher B, Brandauer E, Gschliesser V, Falkenstetter T, Furtner MT, Ulmer H, Poewe W, Högl B. A descriptive analysis of neck myoclonus during routine polysomnography. Sleep 2010; 33:1091-6.

Frauscher B, Gschliesser V, Brandauer E, Marti I, Furtner MT, Ulmer H, Poewe W, Högl B. REM sleep behavior disorder in 703 sleep-disorder patients: the importance of eliciting a comprehensive sleep history. Sleep Med 2010;11:167-71.

 
Other laboratory Members
 
Title MD First Name Birgit Last Name Frauscher Position Vice deputy head E-Mail birgit.frauscher@i-med.ac.at  
Title MD First Name Elisabeth Last Name Brandauer Position Neurologist E-Mail elisabeth.brandauer@i-med.ac.at  
First Name Heinz Last Name Hackner Position Head of sleep technicians E-Mail heinz.hackner@uki.at  
Title MD First Name Viola Last Name Gschliesser Position Resident E-Mail viola.gschliesser@i-med.ac.at  
Title MD First Name Laura Last Name Ehrmann Position Resident E-Mail laura.ehrmann@i-med.ac.at  
Title MD First Name Thomas Last Name Mitterling Position PhD student E-Mail thomas.mitterling@i-med.ac.at  
Title MD First Name David Last Name Gabelia Position PhD student E-Mail david.gabelia@i-med.ac.at  
First Name Marlene Last Name Biermayr Position Medical student E-Mail marlene.biermayr@student.i-med.ac.at  
First Name Aleke Last Name Bode Position Medical student E-Mail aleke.bode@student.i-med.ac.at  
Collaborations
 
 
Past Members