European Sleep Research Laboratories

Sleep, Health & Society: Biochemical Research & Ep

University of Warwick
Warwick Medical School, Division Mental Health and Wellbeing


Michelle A Miller
Gibbet Hill,
CV4 7AL Coventry United Kingdom


Position Associate Prof (Reader) in Biochemical Medicine Phone +44 2476 575104 Fax +44 2476 573297 Contact E-Mail michelle.miller@warwick.ac.uk Website http://www2.warwick.ac.uk/fac/med/research/mhwellbeing/sleep   Research Domain
  • Clinical
  • Basic Human

Keywords
  • Learning, Memory, Cognition
  • Sleep and Ageing
  • Epidemiology of Sleep
  • Sleep and Body Functions (Cardio-Respiratory, Thermoregulation/Metabolism, Endocrine)

Laboratory Description Epidemiology of Sleep: In particular the relation to cardiovascular disease and metabolic function.
Sleep and Health
Meta-analysis
Sleep and Biomarkers
Sleep and inflammation
Sleep and Cognition
Sleep and Pain

Technical Capabilities and areas of expertise Epidemiology & meta-analysis.
Biochemistry and genetics.
Cardiovascular disease.
Psychology and pain.

Additional Descriptors, Keywords Inflammation, Cardiovascular disease, Obesity, Hypertension Type-2 diabetes, Pregnancy, Cognition
Selected Publications in the 5 past years 1. Miller MA. Sleep, Nature’s soft nurse. Is sloth unavoidable? The Biochemist. 2013 Dec; 35(6): 16-22.
2. Cappucio FP & Miller MA. Sleep and mortality: cause, consequence or symptom? Sleep Med. 2013 May 16. doi:pii: S1389-9457(13)00132-9. 10.1016/j.sleep.2013.04.001. [Epub ahead of print]
3. Miller MA & FP Cappuccio (Editorial). Biomarkers of cardiovascular risk in sleep deprived people. JHH 2013, 1-6 (Advance online publication 18 April).
4. Ferrie JE, Kivimäki M, Akbaraly T, Singh-Manoux A, Miller, MA, Gimeno D, Kumari M, Davey-Smith G , Shipley MJ. Associations between change in sleep duration and inflammation: Findings on C-reactive protein and interleukin-6 in the Whitehall II study. Am J Epidemiol. 2013 Sep 15;178(6):956-61. doi: 10.1093/aje/kwt072. Epub 2013 Jun 25.
5. Cappuccio FP & Miller MA (Editorial). A New Challenge to Widely Held Views on The Role of Sleep. Annals of internal Medicine 2012 Oct 16;157(8):593-4. doi: 10.7326/0003-4819-157-8-201210160-00016.
6. Miller MA. Association of inflammatory markers with cardiovascular risk and sleepiness. Journal of Clinical Sleep Medicine. J Clin Sleep Med. 2011 Oct 15;7(5 Suppl):S31-3
7. Miller MA and Cappuccio FP. Sleep, hypertension and diabetes. In. Nutritional and Therapeutic Interventions for Diabetes and Metabolic Syndrome. Eds Debasis Bagchi and Sreejayan Nair. Elsevier. (In press 2011).
8. Cappuccio FP, Cooper D, D’Elia L, Strazzullo P & Miller MA. Sleep duration predicts cardiovascular outcomes: a systematic review and meta-analysis of prospective studies. Eur Heart J 2011; 32: 1484-92
9. Cappuccio FP, Miller MA. Is prolonged lack of sleep associated with obesity? Br Med J 2011; 342: d3306
10. Cappuccio FP, Miller MA. Are short bad sleep nights a hindrance to a healthy heart? Sleep 2011; 34(11): 1457-8
11. Miller MA, Kandala N-B, Kumari M, Marmot MG & Cappuccio FP. Relationships between sleep duration and von Willebrand factor, factor VII and fibrinogen: Whitehall II study. Arterioscler Thromb Vasc Biol 2010; 30: 2032-8
12. Cappuccio FP, D'Elia L, Strazzullo P & Miller MA. Sleep duration and all-cause mortality: a systematic review and meta-analysis of prospective studies. Sleep 2010; 33(5): 585-92
13. Cappuccio FP, D'Elia L, Strazzullo P & Miller MA. Quantity and quality of sleep and incidence of type-2 diabetes: a meta-analysis of prospective studies. Diabetes Care 2010; 33: 414-20
14. Stranges S, Dorn JM, Cappuccio FP, Donahue RP, Rafalson LB, Hovey KM, Freudenheim JL, Kandala N-B, Miller MA & Trevisan M. A population-based study of reduced sleep duration and hypertension: the strongest association may be in pre-menopausal women. J Hypertens 2010; 28(5): 896-902
15. Miller MA, Kandala N-B, Kivimaki M, Kumari M, Brunner EJ, Lowe GDO, Marmot MG & Cappuccio FP. Gender differences in the cross-sectional relationships between sleep duration and markers of inflammation: Whitehall II study. Sleep 2009; 32(7): 857-64
16. Cappuccio FP. 'Hospital at Night' improves outcomes: does the evidence support opinions? (Commentary) Q J Med 2009; 102: 583-4
17. Cappuccio FP, Bakewell A, Taggart FM, Ward G, Ji C, Sullivan JP, Edmunds M, Pounder R, Landrigan CP, Lockley SW & Peile E on behalf of the Warwick EWTD Working Group. Implementing a 48h EWTD-compliant rota for junior doctors in the UK does not compromise patients' safety: assessor-blind pilot comparison. Q J Med 2009; 102: 271-82
18. Cappuccio FP, Lockley SW & Landrigan CP. EWTD is to improve health and safety of patients and doctors. Br Med J 2008; 337: a3080
19. Stranges S, Cappuccio FP, Kandala N-B, Miller MA, Taggart FM, Kumari M, Ferrie JE, Shipley MJ, Brunner E & Marmot MG. Cross-sectional versus prospective associations of sleep duration with changes in relative weight and body fat distribution: the Whitehall II Study. Am J Epidemiol 2008; 167: 321-9
20. Stranges S, Dorn JM, Shipley MJ, Kandala N-B, Trevisan M, Miller MA, Donahue RP, Hovey KM, Ferrie JE, Marmot MG & Cappuccio FP. Correlates of short and long sleep duration: cross-cultural comparison between UK and US. The Whitehall II Study and the Western New York Health Study. Am J Epidemiol 2008; 168: 1353-64
21. Cappuccio FP, Taggart FM, Kandala N-B, Currie A, Peile E, Stranges S & Miller MA. Meta-analysis of short sleep duration and obesity in children and adults. Sleep 2008; 31(5): 619-26
22. Cappuccio FP & Stranges S. Response to: Gender-specific associations of short sleep duration with prevalent hypertension. Hypertension 2008; 51:e17
23. Cappuccio FP, Stranges S, Kandala N-B, Miller MA, Taggart FM, Kumari M, Ferrie JE, Shipley MJ, Brunner EJ & Marmot MG. Gender-specific associations of short sleep duration with prevalent and incident hypertension: the Whitehall II Study. Hypertension; 2007: 50: 694-701
24. Ferrie JE, Shipley MJ, Cappuccio FP, Brunner E, Miller MA, Kumari M & Marmot MG. Sleep duration and change in sleep duration: associations with mortality in the Whitehall II cohort. Sleep 2007; 30: 1659-66
25. Miller MA & Cappuccio FP. Inflammation, sleep, obesity and cardiovascular disease. Curr Vasc Pharm 2007; 5(2):93-102. Review

Key Publications of the Laboratory Books
1. Cappuccio FP, Miller MA, Lockley SW. Sleep, Health & Society: from aetiology to public health. Oxford University Press, 2010; pp. 1-471

Chapters
2. Miller MA, Cappuccio FP. Quantity and quality of sleep and the risk of developing type-2 diabetes. In. Handbook of Nutrition Diet and Sleep. Ed Preedy. Wageningen Academic Publishers; 2013
3. Miller MA, Smith G, O’Keefe A, Cappuccio FP. Sleep and Obesity. In. Handbook of Obesity, Third Edition, Vol. 1, Epidemiology, Etiology, and Physiopathology. Ed Bray and Bouchard (In Press Feb 2013)
4. Miller MA and Cappuccio FP. Sleep, hypertension and diabetes. In. Nutritional and Therapeutic Interventions for Diabetes and Metabolic Syndrome. Eds Debasis Bagchi and Sreejayan Nair. Elsevier. March 2012.
5. Miller MA, Ahuja M and Cappuccio FP. Chapter 1: Sleep deprivation, sleep disturbed breathing and sleep disorders in pregnancy. In. Sleep Disorders. Ed Chris Idzikowski. In Tech. April 2012.
6. Miller MA and Cappuccio FP. Chapter 13: Sleep and Obesity. In. Obesity: Epidemiology, Pathophysiology and Prevention. Ed Debasis Bagchi. CRC Press/Taylor & Francis; 2012 .
7. Cappuccio FP, Miller MA & Lockley SW. Chapter 1: Sleep, Health and Society: the contribution of epidemiology. In: Sleep, health and society: from aetiology to public health. FP Cappuccio, MA Miller, SW Lockley eds. Oxford University Press, 2010; September 23 2010.
8. Cappuccio FP & Miller MA. Chapter 5: The epidemiology of sleep and cardiovascular risk and disease. In: Sleep, health and society: from aetiology to public health. FP Cappuccio, MA Miller, SW Lockley eds. Oxford University Press, 2010; September 23 2010.
9. Miller MA & Cappuccio FP. Chapter 11: Sleep, inflammation and disease. In: Sleep, health and society: from aetiology to public health. FP Cappuccio, MA Miller, SW Lockley eds. Oxford University Press, 2010; September 23 2010.
10. Miller MA. Chapter 12 Genetics & Sleep. In: Sleep, health and society: from aetiology to public health. FP Cappuccio, MA Miller, SW Lockley eds. Oxford University Press, 2010; September 23 2010
11. Cappuccio FP & Miller MA. Chapter 18: European Working Time Directive and medical errors. In: Sleep, health and society: from aetiology to public health. FP Cappuccio, MA Miller, SW Lockley eds. Oxford University Press, 2010; September 23 2010.

Key Papers
12. Cappuccio FP, Cooper D, D’Elia L, Strazzullo P & Miller MA. Sleep duration predicts cardiovascular outcomes: a systematic review and meta-analysis of prospective studies. Eur Heart J 2011; 32: 1484-92
13. Miller MA, Kandala N-B, Kumari M, Marmot MG & Cappuccio FP. Relationships between sleep duration and von Willebrand factor, factor VII and fibrinogen: Whitehall II study. Arterioscler Thromb Vasc Biol 2010; 30: 2032-8
14. Cappuccio FP, D'Elia L, Strazzullo P & Miller MA. Sleep duration and all-cause mortality: a systematic review and meta-analysis of prospective studies. Sleep 2010; 33(5): 585-92
15. Cappuccio FP, D'Elia L, Strazzullo P & Miller MA. Quantity and quality of sleep and incidence of type-2 diabetes: a meta-analysis of prospective studies. Diabetes Care 2010; 33: 414-20
16. Miller MA, Kandala N-B, Kivimaki M, Kumari M, Brunner EJ, Lowe GDO, Marmot MG & Cappuccio FP. Gender differences in the cross-sectional relationships between sleep duration and markers of inflammation: Whitehall II study. Sleep 2009; 32(7): 857-64
17. Cappuccio FP, Taggart FM, Kandala N-B, Currie A, Peile E, Stranges S & Miller MA. Meta-analysis of short sleep duration and obesity in children and adults. Sleep 2008; 31(5): 619-26
18. Cappuccio FP & Stranges S. Response to: Gender-specific associations of short sleep duration with prevalent hypertension. Hypertension 2008; 51:e17
19. Ferrie JE, Shipley MJ, Cappuccio FP, Brunner E, Miller MA, Kumari M & Marmot MG. Sleep duration and change in sleep duration: associations with mortality in the Whitehall II cohort. Sleep 2007; 30: 1659-66
20. Miller MA & Cappuccio FP. Inflammation, sleep, obesity and cardiovascular disease. Curr Vasc Pharm 2007; 5(2):93-102. Review

Current/Completed Grants (past 5 years) 20012-2014. Sleep disturbances and mild cognitive impairment in the English Longitudinal Study of Ageing (Miller MA & Cappuccio FP). ESRC UK £141,145.
2013 Sleep and pain (N Tang, FP Cappuccio, MAMiller, D Wolke) UoW RDF (£6,800).
2013. Sleep & Cognition (Miller MA & Cappuccio). University of Warwick (UoW) £1,000.
2013. Sleep and pain (Tang & Miller).University of Warwick (UoW) £1,000.
2013. Sleep, pain and CBT (Tang & Miller).University of Warwick (UoW) £950.
2012. Meta-analysis of short sleep duration and obesity in children and adults: Prospective studies (Miller & Cappuccio)University of Warwick (UoW) £1,900.
2011-2012. Short and long sleepers: Health effects and implications for sleep functions (Cappuccio & Miller) University of Warwick (UoW) £7,671.
2011. Sleep & pregnancy (Millere & Cappuccio) University of Warwick (UoW) £450.

 
Other laboratory Members
 
Title MD First Name Francesco Middle Name P Last Name Cappuccio Position Cephalon Professor of Cardiovascular Medicine & Epidemiology, Consultant Cardiovascular Physician E-Mail F.P.Cappuccio@warwick.ac.uk  
Title PhD First Name Nicole Middle Name KY Last Name Tang Position Assistant Professor E-Mail n.tang@warwick.ac.uk  
Title PhD First Name Hayley Last Name Wright Position Post Doctoral Research Fellow E-Mail Hayley.Wright@warwick.ac.uk  
Collaborations
 
 
Past Members