European Sleep Research Laboratories

Helsinki Sleep Clinic

Vitalmed Research Centre
Helsinki Sleep Clinic and Research Centre

PhD,MD
Markku Partinen
Sitratori 3
00420 Helsinki Finland


Position Research Director, Adj. Prof Phone +358 10 2311 480 Fax +358 9 440260 Contact E-Mail markpart@mac.com Website http://www.vitalmed.fi   Research Domain
  • Methodology / Technology
  • Clinical
  • Basic Human

Keywords
  • Pharmacology – Human
  • Behavioural Sleep Disorders
  • Paediatric Sleep Disorders
  • Biological Rhythms
  • Epidemiology of Sleep
  • Pharmacology of Sleep
  • Genetics of Sleep
  • Sleep and Medical Disorders
  • Instrumentation-Methodology
  • Neurological Sleep Disorders

Laboratory Description The Helsinki Sleep Clinic has two floors including five bedrooms equipped with telemetric Somnomedics digital devices (DOMINO software). Infrared video is used. Other equipments include Cambridge Neurotech and Somnowatch actigraphies and continuous blood pressure and HRV measurements. The Finnish Narcolepsy Research Centre is situated at the Clinic and we are coordinating the narcolepsy NARPA studies in a Finnish-Swedish consortium. Other members of the consortium include the Biomedicum and Haartman institutes of the Helsinki University, the Finnish Institute for Health and Welfare (THL), and the Karolinska Institutet in Sweden. The research areas include: narcolepsy, sleep apnea, restless legs, RBD, epidemiological sleep research together with the Finnish Twin Registry and molecular biological studies together with the researcher at THL. Currently there is a core group of eight researchers
Additional Descriptors, Keywords parasomnias, nocturnal epilepsy, autonomic nervous system, continuous blood pressure, childhood narcolepsy, clinical trials, ambulatory monitoring, developing of new recording methods
Selected Publications in the 5 past years 1. Virta M, Vedenpää A, Grönroos N, Chydenius E, Partinen M, Vataja R, Kaski M, Iivanainen M. Adults with
ADHD benefit from cognitive-behaviorally oriented group rehabilitation – a study of 29 participants. J Atten Disord 2008; 12 (3) 218-226
2. Härmä M, Partinen M, Repo R, Sorsa M, Siivonen P. Effects of 6/6 and 4/8 watch systems on sleepiness
among bridge officers. Chronobiology International 2008; 25 (2): 413-423.
3. Tuomilehto H, Peltonen M, Partinen M, Seppä J, Saaristo T, Korpi-Hyovalti E, Oksa H, Puolijoki H, Saltevo J,
et al. Sleep duration is associated with an increased risk for the prevalence of type 2 diabetes in middle-
aged women - The FIN-D2D survey. Sleep Med 2008; 9(3): 221-227.
4. Bäck LJ, Liukko T, Rantanen I, Peltola JS, Partinen M, Ylikoski J, Mäkitie AA. Hypertonic saline injections to
enhance the radiofrequency thermal ablation effect in the treatment of base of tongue in obstructive sleep apnoea patients: a pilot study. Acta Otolaryngol 2009; 129(3): 302-310.
5. Ahlberg K, Savolainen A, Paju S, Hublin C, Partinen M, Kononen M, Ahlberg J. Bruxism and sleep efficiency
measured at home with wireless devices. J Oral Rehabil 2008; 35(8): 567-571.
6. Partinen M, Hirvonen K, Jama L, Alakuijala A, Hublin C, Tamminen I, Koester J, Reess J. Open-label study of the
long-term efficacy and safety of pramipexole in patients with Restless Legs Syndrome (extension of the PRELUDE study). Sleep Med 2008; 9(5): 537-541.
7. Veldi M, Vain A, Vasar V, Kull M, Partinen M. Restless legs syndrome is related to difference in tibial muscle tone in the evening, late at night, and morning. Sleep and Biological Rhythms. 2008;6(4):242-8.
8. Płonka-Półtorak E, Chłopicka J, Zagrodzki P, Partinen M, Kaipainen P, Atroshi F, Westermarck T. Free carnitine levels and dietary habits among epileptic patients treated with valproate monotherapy. Epileptologia, 2008, 16: 249-259
9. Jama L, Hirvonen K, Partinen M, Alakuijala A, Hublin C, Tamminen I, Koester J, Rees J. A Dose-Ranging
Study of Pramipexole for the Symptomatic Treatment of Restless Legs Syndrome: Polysomnographic Evaluation of Periodic Leg Movements and Sleep Disturbance. Sleep Med 2009; 10 (6):630-636.
10. Sahlman J, Seppä J, Peltonen M, Pukkila M, Partinen M, Tuomilehto H. Surgical intervention represents a feasible option for patients with mild obstructive sleep apnoea. Acta Otolaryngol. 2009;129(11):1266-73.

11. Paunio T, Korhonen T, Hublin C, Partinen M, Kivimaki M, Koskenvuo M, et al. Longitudinal study on poor sleep and life dissatisfaction in a nationwide cohort of twins. Am J Epidemiol. 2009;169(2):206-13.
12. Bäck LJ, Liukko T, Rantanen I, Peltola JS, Partinen M, Ylikoski J, et al. Radiofrequency surgery of the soft palate in the treatment of mild obstructive sleep apnea is not effective as a single-stage procedure: A randomized single-blinded placebo-controlled trial. Laryngoscope 2009; 119 (8): 1621-1627.
13. Virta M, Salakari A, Antila M, Chydenius E, Partinen M, Kaski M, Vataja R, Kalska H, Iivanainen M. Short cognitive behavioural therapy and cognitive training for adults with ADHD – a randomized controlled pilot study. Neuropsychiatric Disease and Treatment 2010; 6: 443-453.
14. Hublin C, Partinen M, Koskenvuo K, Silventoinen K, Koskenvuo M, Kaprio J. Shift-work and cardiovascular disease: a population-based 22-year follow-up study. Eur J Epidemiol. 2010;25:315-23.
15. Koskenvuo K, Hublin C, Partinen M, Paunio T, Koskenvuo M. Childhood adversities and quality of sleep in adulthood: A population-based study of 26,000 Finns. Sleep Med. 2010;11: 17-22.
16. Sahlman J, Miettinen K, Peuhkurinen K, Seppa J, Peltonen M, Herder C, Punnonen K, et al. The activation of the inflammatory cytokines in overweight patients with mild obstructive sleep apnoea. J Sleep Res. 2010;19:341-8.

17. Broms U, Kaprio J, Hublin C, Partinen M, Madden PA, Koskenvuo M. Evening types are more often current
smokers and nicotine-dependent-a study of Finnish adult twins. Addiction. 2011;106:170-7.
18. Dick R, Penzel T, Fietze I, Partinen M, Hein H, Schulz J. AASM standards of practice compliant validation of
actigraphic sleep analysis from SOMNOwatch versus polysomnographic sleep diagnostics shows high conformity also among subjects with sleep disordered breathing. Physiol Meas. 2010;31:1623-33.
19. Hublin C, Partinen M, Koskenvuo M, Kaprio J. Heritability and mortality risk of insomnia-related symptoms: a genetic epidemiologic study in a population-based twin cohort. Sleep. 2011; 34(7): 957-64.
20. Lahti T, Methuen T, Roine R, Seppa KL, Sinclair D, Partinen M, et al. The impacts of nitrous oxide gas on sleep quality during alcohol withdrawal. BMC Res Notes. 2011; 4: 108.
21. Gradinger F, Cieza A, Stucki A, Michel F, Bentley A, Oksenberg A, Rogers AE, Stucki G, Partinen M. Part 1.
International Classification of Functioning, Disability and Health (ICF) Core Sets for persons with sleep disorders: Results of the consensus process integrating evidence from preparatory studies. Sleep Med 2011;12:92-96.

22. Ounjaijean S, Westermarck T, Partinen M, Plonka-Poltorak E, Kaipainen P, Kaski M, et al. Increase in non-transferrin bound iron and the oxidative stress status in epilepsy patients treated using valproic acid monotherapy. Int J Clin Pharmacol Ther. 2011; 49(4): 268-76.
23. Paalasmaa J, Leppäkorpi L, Partinen M. Quantifying respiratory variation with force sensor measurements.
Conf Proc IEEE Eng Med Biol Soc. 2011; 2011: 3812-5.
24. Nohynek H, Jokinen J, Partinen M, Vaarala O, Kirjavainen T, Sundman J, et al. AS03 adjuvanted AH1N1 vaccine
associated with an abrupt increase in the incidence of childhood narcolepsy in Finland. PLoS ONE. 2012;PONE-D-11-23379R1
1035-44.
25. Partinen M, Saarenpää-Heikkilä O, Ilveskoski I, Hublin C, Linna M, Olsén P, et al. Increased incidence and
clinical picture of childhood narcolepsy observed after the 2009 H1N1 pandemic vaccination campaign in
Finland Plos ONE. 2012;7 (3): e33723. doi: 10.137/journal.pone.0033723.

Key Publications of the Laboratory 1. Partinen M, Kaprio J, Koskenvuo M, Putkonen PTS, Langinvainio H. Genetic and environmental
determination of human sleep. Sleep 1983;6:179-185.
2. Koskenvuo M, Kaprio J, Partinen M, Langinvainio H, Sarna S, Heikkilä K. Snoring as a risk factor for
hypertension and angina pectoris. Lancet 1985;1:893-896.
3. Partinen M, Palomäki H. Snoring and cerebral infarction. Lancet 1985;ii:1325-1326.
4. Telakivi T, Partinen M, Salmi T, Leinonen L, Härkönen T. Nocturnal periodic breathing in adults with
Down's syndrome. J Ment Def Res 1987;31:31-39.
5. Koskenvuo M, Kaprio J, Telakivi T, Partinen M, Heikkilä K, Sarna S. Snoring as a risk factor for
ischaemic heart disease and stroke in men. Br Med J 1987;294:16-19.
6. Pekkarinen T, Partinen M, Pelkonen R, Iivanainen M. Sleep apnoea and daytime sleepiness in
acromegaly: relationship to endocrinological factors. Clinical Endocrinology 1987;27:649-654.
7. Palomäki H, Partinen M, Juvela S, Kaste M. Snoring as a risk factor for sleep-related brain infarction.
Stroke 1989; 20: 1311-1315.
8. Partinen M, Guilleminault C. Daytime sleepiness and vascular morbidity at seven-year follow-up in
obstructive sleep apnea patients. Chest 1990; 97: 27-32.
9. Seppälä T, Partinen M, Penttilä A, Aspholm R, Tiainen E, Kaukiainen A. Sudden death and sleeping
history among Finnish men. J Int Med 1991; 229: 23-28.
10. Partinen M, Telakivi T, Kaukiainen A, Salmi T, Färkkilä M, Saijonmaa O, Fyhrquist F. Atrial natriuretic
peptide in habitual snorers. Ann Med 1991; 23: 147-151.
11. Palomäki H, Partinen M, Erkinjuntti T, Kaste M. Snoring, sleep apnea syndrome and stroke.
Neurology 1992; 42 (6): 75-82.
12. Tiihonen M, Partinen M, Närvänen S. The severity of obstructive sleep apnoea is associated with
insulin resistance. J Sleep Res 1993; 2: 56-61.
13. Hublin C, Kaprio J, Partinen M, Koskenvuo M, Heikkilä K. The Ullanlinna Narcolepsy Scale: validation of
a measure of symptoms in the narcoleptic syndrome. J Sleep Res 1994; 3: 52-59.
14. Hublin C, Kaprio J, Partinen M, Koskenvuo M, Heikkilä K, Koskimies S, Guilleminault C. The
prevalence of narcolepsy: an epidemiologic study of the Finnish narcolepsy cohort. Ann Neurol 1994; 35: 709-716.
15. Partinen M, Gislason T. Basic nordic sleep questionnaire (BNSQ): a quantitated measure of
subjective sleep complaints. J Sleep Res 1995; 4 (Suppl 1): 150-155.
16. Kajaste S, Telakivi T, Mustajoki P, Pihl S, Partinen M. Effects of a cognitive-behavioural programme on
overweight in obstructive sleep apnoea. J Sleep Res 1994; 3: 245-249.
17. Rinne JO, Hublin C, Partinen M, Ruottinen H, Ruotsalainen U, Någren K, Lehikoinen P, Laihinen A.
Positron emission tomography study of human narcolepsy: no increase in striatal dopamine D2-receptors. Neurology, 1995; 45: 1735-1738.
18. Hublin C, Kaprio J, Partinen M, Heikkilä K, Koskenvuo M. Prevalence and genetics of sleepwalking:
a population-based twin study. Neurology 1997; 48: 177-181.
19. Ruottinen HM, Partinen M, Hublin C, Bergman J, Haaparanta M, Solin O, Rinne JO. An FDOPA PET
study in patients with periodic limb movement disorder and restless legs syndrome. Neurology 2000; 54: 502-504.
20. Kajaste S, Brander P, Telakivi T, Partinen M, Mustajoki P. A cognitive-behavioral weight reduction program
in the treatment of obstructive sleep apnea syndrome with or without initial nasal CPAP: a randomized study. Sleep Med 2004; 5: 125-131.
21. Porthan KM, Melin JH, Kupila JT, Venho KK, Partinen MM. Prevalence of sleep apnea syndrome in
lone atrial fibrillation: a case-control study. Chest 2004;125(3): 879-85.
22. Hublin C, Partinen M, Koskenvuo M, Kaprio J. Sleep and mortality: a population-based 22-
year follow-up study. Sleep 2007, 30 (10): 1245-1253.
23. Paunio T, Korhonen T, Hublin C, Partinen M, Kivimaki M, Koskenvuo M, et al. Longitudinal study on poor sleep and life dissatisfaction in a nationwide cohort of twins. Am J Epidemiol. 2009;169(2):206-13.
24. Nohynek H, Jokinen J, Partinen M, Vaarala O, Kirjavainen T, Sundman J, et al. AS03 adjuvanted AH1N1 vaccine
associated with an abrupt increase in the incidence of childhood narcolepsy in Finland. PLoS ONE. 2012;PONE-D-11-23379R1
1035-44.
25. Partinen M, Saarenpää-Heikkilä O, Ilveskoski I, Hublin C, Linna M, Olsén P, et al. Increased incidence and
clinical picture of childhood narcolepsy observed after the 2009 H1N1 pandemic vaccination campaign in
Finland Plos ONE. 2012;7 (3): e33723. doi: 10.137/journal.pone.0033723.

Current/Completed Grants (past 5 years) Rinnekoti Foundation
Academy of Finland (Obesity and sleepiness) 2009-2012
Academy of Finland (RLS) 2010-2013
Academy of Finland and Vetenskapsrådet in Sweden (NARPANord Consortium) 2012-2015
Parkinson Foundation (RBD and Parkinsonism)
Gyllenberg Foundation (Daytime sleepiness)

 
Other laboratory Members
 
Collaborations
 
Past Members