European Sleep Research Laboratories

Outpatient clinic for Sleep-disorders and Chronobi

Hospital Gelderse Vallei
Neurology / Sleep disorders


Marcel G. Smits
Box 9025
6710 HN Ede Netherlands


Position Head sleep centre Phone +31 318435018 Fax +31 318435025 Contact E-Mail smitsm@zgv.nl   Research Domain
  • Clinical

Keywords
  • Neurological Sleep Disorders
  • Learning, Memory, Cognition
  • Sleep and Medical Disorders
  • Genetics of Sleep
  • Pharmacology of Sleep
  • Sleep and Ageing
  • Sleep and Psychiatry-Personality Disorders
  • Sleep and Body Functions (Cardio-Respiratory, Thermoregulation/Metabolism, Endocrine)
  • Sleep Physiology-Neurophysiology in Human
  • Biological Rhythms
  • Paediatric Sleep Disorders
  • Behavioural Sleep Disorders
  • Pharmacology – Human

Laboratory Description fully equiped laboratory for home registrations and melatonin measurements
Technical Capabilities and areas of expertise Sleep in children
sleep in adults with ADHD
sleep in autisme
sleep in mentally handicapped people

Selected Publications in the 5 past years Reference List

1 Maanen A.van, Dewald JF, Smits MG, Meijer AM: Chronic sleep reduction in adolescents with delayed sleep phase syndrome and effects of melatonin treatment. Sleep-Wake Res in the Netherlands 2012;23:89.
2 van Geijlswijk IM, Promotoren Prof Dr H.Vaarkamp en A.C.G.Egbert, Co-promotor Dr.M.G.Smits: Melatonin in sleepless children: Everything has a rhythm?; UMCU, 20121.
3 Nagtegaal JE, Laurant MW, Kerkhof GA, Smits MG, van der Meer YG, Coenen AM: Effects of melatonin on the quality of life in patients with delayed sleep phase syndrome. J Psychosom Res 2000;48:45-50.
4 Maas AP, Didden R, Korzilius H, Braam W, Collin P, Smits MG, Curfs LM: Psychometric properties of a sleep questionnaire for use in individuals with intellectual disabilities. Res Dev Disabil 2011;32:2467-2479.
5 van MA, Meijer AM, Smits MG, Oort FJ: Termination of short term melatonin treatment in children with delayed Dim Light Melatonin Onset: effects on sleep, health, behavior problems, and parenting stress. Sleep Med 2011;12:875-879.
6 Braam W., Didden R, Maas A, Korzilius H, Smits.M.G., Curfs L: Melatonin decreases daytime challenging behaviour in persons with intiellectual disability and chronic insomnia. Sleep-wake research in The Netherlands 2011;22:98.
7 Maanen A.van, Meijer AM, Smits.M.G., Oort FJ: Melatonin and sleep effects on health, behavior problems and parenting stress. Sleep-wake research in The Netherlands 2011;22:113.
8 Kakkhar S, Smits MG, Hoentjen E, Verheul J: Awake at shift work. Preventive measures for shift workers. Sleep-wake research in The Netherlands 2011;22:63-65.
9 Nauta APTMBGMv, Moerman EJ, Smits MG: Gifted adults and their sleep - A small survey. Sleep-Wake Res in the Netherlands 2011;22:68-71.
10 Smits MG, Keijzer H, Braam W., Didden R, Maas A, Curfs L: Why Dim Light Melatonin Onset (DLMO) should be measured before starting melatonin treatment. Sleep-wake research in The Netherlands 2011;22:76-81.
11 Maas AP, Didden R, Korzilius H, Braam W, Collin P, Smits MG, Curfs LM: Psychometric properties of a sleep questionnaire for use in individuals with intellectual disabilities. Res Dev Disabil 2011;32:2467-2479.
12 Kruithof W, Smits MG, Teunissen LL: The added value of Dim Light Melatonin Onset in diagnosing idiopathic Delayed Speel Phase Disorder. Sleep Science 2011;4:93-99.
13 Keijzer H, Smits MG, Endenburg SC, Koopmann M, Gunnewiek JMT: Can slow melatonin metabolism be associated with a single nucleotide polymorphism in the CYP1A2 gene. Sleep-wake research in The Netherlands 2010;21:77-80.
14 Keijzer H, Endenburg SC, Smits MG, Koopmann M: Automated genomic DNA extraction from saliva using the QIAxtractor. Clin Chem Lab Med 2010.
15 Braam W, van G, I, Keijzer H, Smits MG, Didden R, Curfs LM: Loss of response to melatonin treatment is associated with slow melatonin metabolism. J Intellect Disabil Res 2010;54:547-555.
16 Maas AP, Sinnema M, Didden R, Maaskant MA, Smits MG, Schrander-Stumpel CT, Curfs LM: Sleep disturbances and behavioural problems in adults with Prader-Willi syndrome. J Intellect Disabil Res 2010;54:906-917.
17 van Geijlswijk IM, Korzilius HP, Smits MG: The use of exogenous melatonin in delayed sleep phase disorder: a meta-analysis. Sleep 2010;33:1605-1614.
18 van Geijlswijk IM, Van der Heijden KB, Egberts AC, Korzilius HP, Smits MG: Dose finding of melatonin for chronic idiopathic childhood sleep onset insomnia: an RCT. Psychopharmacology (Berl) 2010;212:379-391.
19 Hoebert M, Van der Heijden KB, van Geijlswijk IM, Smits MG: Long-term follow-up of melatonin treatment in children with ADHD and chronic sleep onset insomnia. J Pineal Res 2009;47:1-7.
20 Maas AP, Didden R, Bouts L, Smits MG, Curfs LM: Scatter plot analysis of excessive daytime sleepiness and severe disruptive behavior in adults with Prader-Willi syndrome: a pilot study. Res Dev Disabil 2009;30:529-537.
21 Braam W, Smits MG, Didden R, Korzilius H, van Geijlswijk IM, Curfs LM: Exogenous melatonin for sleep problems in individuals with intellectual disability: a meta-analysis. Dev Med Child Neurol 2009;51:340-349.
22 Hoebert M, Van der Heijden KB, van Geijlswijk IM, Smits MG: Long-term follow-up of melatonin treatment in children with ADHD and chronic sleep onset insomnia. J Pineal Res 2009;47:1-7.
23 Maas AP, Didden R, Korzilius H, Braam W, Smits MG, Curfs LM: Sleep in individuals with Cri du Chat syndrome: a comparative study. J Intellect Disabil Res 2009;53:704-715.
24 Alders J, Smits M, Kremer B, Naarding P: The role of melatonin in sleep disturbances in end-stage Huntington's disease. J Neuropsychiatry Clin Neurosci 2009;21:226-227.
25 Hoebert M, Smits M, Van der Heijden K: Long term follow up of melatonin treatment in children with ADHD and chronic sleep onset insomnia. jsr 2008;17:188-189.



Key Publications of the Laboratory See above
 
Other laboratory Members
 
 
Title PhD,MD First Name Maarten Last Name Majoor Position Throat Nose and Ear E-Mail majoorm@zgv.nl  
Collaborations
 
Past Members