European Sleep Research Laboratories

Antwerp Multidisciplinary Sleep Disorders Centre

Antwerp University Hospital and University of Antwerp
Dept of Sleep Medicine


Johan A Verbraecken
Wilrijkstraat 10
B-2650 Edegem (Antwerp) Belgium


Position Medical Coordinator Phone +32 3 821 38 00 Fax +32 3 821 42 97 Contact E-Mail johan.verbraecken@uza.be Website http://www.uza.be   Research Domain
  • Methodology / Technology
  • Clinical

Keywords
  • Instrumentation-Methodology
  • Sleep and Medical Disorders
  • Neurological Sleep Disorders

Laboratory Description Our centre, funded in 1979, aims at offering optimal diagnostics and treatment for all kind of sleep-wake disorders in adults. Our research focuses predominantly on pathophysiology of sleep-disordered breathing and innovative treatment modalities, like hyoid expansion, tongue anchor implant and upper airway pacing. Patient selection and phenotyping of the upper airway in OSA is of utmost importance, and is part of most studies. We participate in clinical trials like the Star trial (Inspire Medical Systems), vigilance drug studies (Bioprojet), and in many trials in insomnia and restless legs. Recently, we started trials on the evaluation of cognitive behaviour in OSA patients, on sleep misperception and on innovative bedding systems.
Technical Capabilities and areas of expertise State of the art Sleep Centre with 11 beds for polysomnography, open 7 days a week. We offer standard video-PSG in all patients, capnography is optional and available in each room. We deliver supervised polysomnographic CPAP and bilevel CPAP titration.
Additional Descriptors, Keywords CPAP, MAD, upper airway surgery, pacing, drug therapy, cardiovascular consequences, personality, sleep endoscopy, functional imaging.
Selected Publications in the 5 past years 1) Continuous positive airway pressure therapy is associated with increase of intraocular pressure in obstructive sleep apnea. S. Kiekens, V. De Groot, T. Coeckelbergh, M.J. Tassignon, P. Van de Heyning, W. De Backer, J. Verbraecken. Investigative Ophtalmology & Visual Science 2008, 49(3):934-940.

2) Comparison of a custom-made and a thermoplastic oral appliance for the treatment of mild sleep apnea. OM Vanderveken, A. Devolder, M. Marklund, A.N. Boudewyns, M.J. Braem, W. Okkerse, J. Verbraecken, KA Franklin, WA De Backer, PH Van de Heyning. Am J Respir Crit Care Med 2008, 178:197-202.

3) Adjustable tongue advancement for obstructive sleep apnea: a pilot study. E. Hamans, A. Boudewyns, B Stuck, A. Baisch, M. Willemen, J. Verbraecken, P. Van de Heyning. Ann Otol Rhinol Laryngol 2008, 117(11):815-823.

4) Upper airway mechanics. J. Verbraecken, W. De Backer. Respiration 2009;78:121-133.

5) Heart rate based nighttime awakening detection. A. Bulckaert, V. Exadaktylos, G. De Bruyne, B. Haex, E. De Valck, J. Wuyts, J. Verbraecken, D. Berckmans. Eur J Appl Physiol 2010;109(2):317-22.

6) Outcome of sleep endoscopy in obstructive sleep apnea: the Antwerp experience. E. Hamans, O. Meeus, A. Boudewyns, V. Saldien, J. Verbraecken, P. Van de Heyning. B-ENT 2010, 6:97-103.

7) Cardiovascular implications in the treatment of obstructive sleep apnea. Vanderveken OM, Boudewijns A, Ni Q, Kashyap B, Verbraecken J, De Backer W, Van de Heyning P. J Cardiovasc Translat Research 2011;4(1):53-60.

8) Ergonomics in bed design: the effect of spinal alignment on sleep parameters. J. Verhaert, B. Haex, T. De Wilde, D. Berckmans, J. Verbraecken, E. De Valck, J. Vander Sloten. Ergonomics 2011;54(2):169-178.

9) Management of Obstructive Sleep Apnea in Europe. Fietze I, Penzel T, Alonderis A, Barbe F, Bonsignore M, Calverly P, De Backer W, Diefenbach K, Donic V, Eijsvogel M, Franklin KA, Gislason T, Grote L, Hedner J, Jennum P, Lavie L, Lavie P, Levy P, Lombardi C, Mallin W, Marrone O, Montserrat JM, Papathanasiou ES, Parati G, Plywaczewski R, Pretl M, Riha RL, Rodenstein D, Saaresranta T, Schulz R, Sliwinski P, Steiropoulos P, Svaza J, Tomori Z, Tonnesen P, Varoneckas G, Verbraecken J, Vesely J, Vitols A, Zielinski J, McNicholas WT on behalf of the COST Action B26 Group. Sleep Med 2011;12:190-197.

10) Non-CPAP Therapies in Obstructive Sleep Apnoea. WJ Randerath*, J Verbraecken* (*equal authors), S Andreas, G Bettega, A Boudewyns, E Hamans, F Jalbert, JR Paoli, B Sanner, I Smith, BA Stuck, L Lacassagne, M Marklund, JT Maurer, JL Pepin, A Valipour, T Verse, I Fietze. Non CPAP therapies in OSA. Eur Respir J 2011;37:1000-1028.

11) Elevated variance in heart rate during slow-wave sleep after late-night physical activity. A. Bulckaert, V. Exadaktylos, B. Haex, E. De Valck, J. Verbraecken, D. Berckmans. Chronobiol Intern 2011;28(3):282-284.

12) Unobstrusive assessment of motor patterns during sleep based on mattress indentation measurements. V. Verhaert, B. Haex, T. De Wilde, D. Berckmans, M. Vandekerckhove, J. Verbraecken, J. Vander Sloten. IEEE Trans Inf Technol Biomed 2011;15(5):787-794.

13) Sleep HERMES: a European training project for respiratory sleep medicine. W. De Backer, A. Simonds, V. Horn, S. Andreas, M. Bonsignore, P. Calverley, V. Donic, P. Levy, S. Mitchell, W. McNicholas, M. Morrell, W. Randerath, R. Riha, H. Trang, J. Verbraecken, P. Palange. Eur Respir J 2011; 38:496-497.

14) The role of presleep negative emotion in sleep physiology. Vandekerckhove M, Weiss R, Schotte C, Exadaktylos V, Haex B., Verbraecken J., Cluydts R. Psychophysiology 2011; 48(12):1738-1744.

15) The place of polysomnography in internal medicine. Verbraecken J, Moorkens G. Acta Clin Belg 2011;66(6):432-437.

16) The influence of pre-sleep cognitive arousal on sleep onset processes. J. Wuyts, E. De Valck, M. Vandekerckhove, N. Pattyn, A. Bulckaert, D. Berckmans, B. Haex, J. Verbraecken, R. Cluydts. Int J Psychophysiol 2012;83(1):8-15.

17) Position paper on the management of patients with obstructive sleep apnea and hypertension: Joint recommendations by the European Society of Hypertension, by the European Respiratory Society and by the members of European COST (Cooperation in Scientific and Technological research) ACTION B26 on Obstructive Sleep Apnea. Parati G, Lombardi C, Hedner J, Bonsignore M, Grote L, Tkacova R, Levy P, Riha R, Bassetti C, Narkiewicz K, Mancia G, McNicholas W, on behalf of the EU COST ACTION B26 members. J Hypertension 2012;30(4):633-646.

18) Non-CPAP therapies in obstructive sleep apnoea: mandibular advancement device therapy. M. Marklund, J. Verbraecken, W. Randerath. Eur Respir J 2012, 39:1241-1247.

19) Implanted Upper Airway Stimulation Device for Obstructive Sleep Apnea. P. Van de Heyning, . S. Badr, J. Z. Baskin, M.C. Borneman, W. De Backer, Y. Dotan, W. Hohenhorst, L. Knaack, H. Lin, J.T. Maurer, A. Netzer, R. Odland, A. Oliven, K. P. Strohl, O. Vanderveken, J. Verbraecken, B.T. Woodson. The Laryngoscope 2012; 122(7):1626-33.

20) Disturbed sleep and COPD outcomes: cart meet horse. B. Kent, W. McNicholas, J. Verbraecken. Sleep Med 2012;13:453-454.

21) Estimating spine shape during sleep using silhouette-derived body shape models. Verhaert V, Druyts H, Van Deun D, Exadaktylos V, Verbraecken J, Vandekerckhove M, Haex B, Vander Sloten J. International J Industrial Ergonomics 2012;42:489-498.

22) Effects of pre-sleep simulated on-call instructions on subsequent sleep. J. Wuyts, E. De Valck, M. Vandekerckhove, N. Pattyn, V. Exadaktylos, B. Haex, J. Maes, J. Verbraecken, R. Cluydts. Biol Psychol 2012;91:383-388.

23) Treatment of obstructive sleep apnea using a custom-made titratable duobloc oral aplliance: a prospective clinical trial. M. Dieltjens, O.M. Vanderveken, E. Hamans, J.A. Verbraecken, K. Wouters, M. Willemen, W.A. De Backer, P.H. Van de Heyning, M.J. Braem. Sleep Breath 2012;in press.

24) Hyoid expansion technique in obstructive sleep apnoea. E. Hamans, B. Stuck, N. De Vries, A. Boudewyns, A. Devolder, J. Verbraecken, P. Van de Heyning. Sleep Breathing 2012 ; in press.

25) Cardiovascular mechanisms and consequences of obstructive sleep apnoea. Vrints H, Shivalkar B, Heuten H, Vanderveken OM, Hamans E, Van de Heyning P, De Backer W, Verbraecken J. Acta Clin Belg 2012; in press.


Key Publications of the Laboratory (1) Schwartz AR, Bennett ML, Smith PL, et al. Therapeutic electrical stimulation of the hypoglossal nerve in obstructive sleep apnea. Arch Otolaryngol Head Neck Surg 2001;127:1216-1223.

(2) Oliven A, O'Hearn DJ, Boudewyns A, et al. Upper airway response to electrical stimulation of the genioglossus in obstructive sleep apnea. J Appl Physiol 2003;95:2023-2029.

(3) Boudewyns A, Van de Heyning P. Temperature controlled radiofrequency tissue volume reduction of the soft palate (Somnoplasty R) in the treatment of habitual snoring. Results of a European Multicenter Trial. Acta Otolaryngol (Stockh) 2000;120:981-985.

(4) Hamans EP, Van Marck EA, De Backer WA, et al. Morphometric analysis of the uvula in patients with sleep-related breathing disorders. Eur Arch Otorhinolaryngol 2000;257:232-236.

(5) Hamans E, Boudewyns A, Stuck B, et al. Adjustable tongue advancement for Obstructive Sleep Apnea: a Pilot Study. Ann Otol Rhinol Laryngol 2008:117:815-823.

(6) Vanderveken OM, Oostveen E, Boudewyns AN, et al. Quantification of pharyngeal patency in patients with sleep-disordered breathing. ORL J Otorhinolaryngol Relat Spec 2005:67:168-179.

(7) Vos W, De Backer J, Devolder A, et al. Correlations between severity of sleep apnea and upper airway morphology based on advanced anatomical and functional imaging. J Biomech 2007;40(10):2207-13.

(8) De Backer J, Vanderveken O, Vos W, et al. Functional imaging using computational fluid dynamics to predict treatment success of mandibular advancement devices in sleep-disordered breathing. J Biomech 2007; 40:16: 3708-3714.

(9) Verbraecken J, De Backer W, Willemen M, et al. Chronic CO2 drive in patients with obstructive sleep apnea and effect of CPAP. Respir Physiol, 1995;101:279-287.

(10) Verbraecken J, Willemen M, De Cock W, et al. Influence of longterm CPAP therapy on CO(2) drive in patients with obstructive sleep apnea. Respir Physiol 2000;123:121-130.

(11) De Backer WA, Verbraecken J, Willemen M, et al. Central apnea index decreases after prolonged treatment with acetazolamide. Am J Respir Crit Care Med 1995;151:87-91.

(12) Verbraecken J, Willemen M, De Cock W, et al. Central sleep apnea after interrupting longterm acetazolamide therapy. Respir Physiol 1998; 112:59-70.

(13) Verbraecken J, Willemen M, Wittesaele W, et al. Short-term CPAP does not influence the increased CO2 drive in idiopathic central sleep apnea. Monaldi Arch Chest Dis 2002;57:10-18.

(14) Verbraecken J, Willemen M, De Cock W, et al. Relationship between CO2 drive and characteristics of apneas in obstructive and central sleep apnea. Respir Physiol 1998;114:185-194.

(15) Boudewyns A, Punjabi N, Van de Heyning PH, et al. Abbreviated method for assessing upper airway function in obstructive sleep apnea. Chest 2000;118:1031-1041.

(16) Boudewyns AN, Van de Heyning P, De Backer WA. Site of upper airway obstruction in obstructive apnoea and influence of sleep stage. Eur Respir J 1997;10:2566-2572.

(17) Boudewyns A, Willemen M, Wagemans M, et al. Assessment of respiratory effort by means of strain gauges and esophageal pressure swings: a comparative study. Sleep1997;20:168-170.

(18) Boudewyns A, De Cock W, Willemen M, et al. Influence of uvulopalatopharyngoplasty on alpha-EEG arousals in nonapnoeic snorers. Eu. Respir J 1997;10:129-132.

(19) Schneider H, Boudewyns A, Smith PL, et al. Modulation of upper airway collapsibility during sleep: Influence of respiratory phase and airflow regimen. J Appl Physiol 2002;93:1365-1376.

(20) Vanderveken OM, Devolder A, Marklund M, et al. Comparison of a custom-made and a thermoplastic oral appliance for the treatment of mild sleep apnea. Am J Respir Crit Care Med 2008;178:197-202.

(21) Shivalkar B, Van de Heyning C, Kerremans M, et al. Obstructive sleep apnea syndrome: more insights on structural and functional cardiac alterations, and the effects of treatment with continuous positive airway pressure. J Am Coll Cardiol 2006;47:1433-1439.

(22) B. Shivalkar, M. Kerremans, C. Van de Heyning, D. Rinkevich, J. Verbraecken, W. De Backer, C. Vrints. Research Highlights: Structural and functional cardiac consequences of obstructive sleep apnea.
Nature Clinical Practice Cardiovascular Medicine 2006, 3(7): 348.

(23) S. Kiekens, V. De Groot, T. Coeckelbergh, M.J. Tassignon, P. Van de Heyning, W. De Backer, J. Verbraecken. Continuous positive airway pressure therapy is associated with increase of intraocular pressure in obstructive sleep apnea. Investigative Ophtalmology & Visual Science 2008, 49(3):934-940.

(24) J. Verbraecken, W. De Backer. Upper airway mechanics. Respiration 2009;78:121-133.

(25) WJ Randerath*, J Verbraecken* (*equal authors), S Andreas, G Bettega, A Boudewyns, E Hamans, F Jalbert, JR Paoli, B Sanner, I Smith, BA Stuck, L Lacassagne, M Marklund, JT Maurer, JL Pepin, A Valipour, T Verse, I Fietze. Non CPAP therapies in OSA. Eur Respir J 2011;37:1000-1028.

Current/Completed Grants (past 5 years) IWT. SBO EASI (Enhancing activity through sleep improvement). 2.9 milj €.

IWT. Mandibular advancement devices (750.000 €)

ERS Task Force on Non-CPAP therapies in obstructive sleep apnoea.

ERS Task Force on Central Sleep Apnoea.

 
Other laboratory Members
 
Title MD First Name Ilse Last Name De Volder Position neurologist E-Mail ilse.de.volder@uza.be  
Title MD First Name Ann Last Name Van Gastel Position Psychiatrist E-Mail ann.van.gastel@uza.be  
Title PhD,MD First Name An Last Name Boudewyns Position ENT E-Mail an.boudewyns@uza.be  
Title PhD,MD First Name Olivier Last Name Vanderveken Position ENT E-Mail olivier.vanderveken@uza.be  
Title PhD,MD First Name Olivier Last Name Vanderveken Position ENT E-Mail olivier.vanderveken@uza.be  
Title MSc,PhD First Name Raymond Last Name Cluydts Position Psychologist-scientist E-Mail raymond.cluydts@uza.be  
Title MSc First Name Marc Last Name Willemen Position Non-medical coordinator E-Mail marc.willemen@uza.be  
First Name Christa Last Name Goossens Position Unit responsible E-Mail christine.goossens@uza.be  
Collaborations
 
 
Past Members
 
Title PhD,MD First Name Jacques Last Name De Roeck Position Psychiatrist  
Title MD First Name Karin Last Name Heyde Position Psychiatrist  
Title MD First Name Bart Last Name Leroy Position Psychiatrist  
First Name Winfried Last Name De Cock Position chief-technician