European Sleep Research Laboratories

Le laboratoire du sommeil

CHU de Grenoble
Clin Univ. de physiologie, sommeil et exercice

Jean-Louis Pépin
CS 10217
38043 Grenoble France

Position Responsible Phone +33 476 765 516 Fax +33 476 765 586 Contact E-Mail Website   Research Domain
  • Clinical
  • Basic Human

  • Others
  • Sleep and Medical Disorders
  • Epidemiology of Sleep
  • Sleep and Body Functions (Cardio-Respiratory, Thermoregulation/Metabolism, Endocrine)
  • Sleep Physiology-Neurophysiology in Human
  • Behavioural Sleep Disorders

Laboratory Description HP2 : Hypoxia ; Pathophysiology, INSERM U 1042 :
We have developed an original research project on cardiovascular consequences in intermittent hypoxia and sleep apnea using both animal, translational and clinical research. We are addressing general adaptations to hypoxia, not only during sleep but also during exercise. This is specifically the case regarding interactions between muscle, adipose tissue, brain and hypoxia. The structure of the laboratory and the scientific project are based on 4 teams, 2 on animal research (one on Vascular remodelling and atherosclerosis, the other one on Adaptation to chronic intermittent hypoxia: HIF-1 and its target genes) and 2 on translational and clinical research (one on sleep apnea and hypoxia, the other one on exercise and hypoxia).

Additional Descriptors, Keywords Hypoxie-physiology
Sleep and exercise

Selected Publications in the 5 past years 1- Totoson P, Fhayli W, Faury G, Korichneva I, Cachot S, Baldazza M, Ribuot C, Pépin JL, Lévy P, Joyeux-Faure M. Atorvastatin protects against deleterious cardiovascular consequences induced by chronic intermittent hypoxia. Exp Biol Med (Maywood). 2013 Feb 12. [Epub ahead of print] PubMed PMID: 23404941.

2- Caldarelli V, Borel JC, Khirani S, Ramirez A, Cutrera R, Pépin JL, Fauroux B. Polygraphic respiratory events during sleep with noninvasive ventilation inchildren: description, prevalence, and clinical consequences. Intensive Care Med. 2013 Jan 24. [Epub ahead of print] PubMed PMID: 23344829.

3- Borel JC, Burel B, Tamisier R, Dias-Domingos S, Baguet JP, Levy P, Pepin JL.
Comorbidities and Mortality in Hypercapnic Obese under Domiciliary Noninvasive Ventilation. PLoS One. 2013;8(1):e52006.
4- Pépin JL, Borel JC, Janssens JP. Obesity hypoventilation syndrome: an underdiagnosed and undertreated condition. Am J Respir Crit Care Med. 2012;186:1205-7.

5- Rabec C, Langevin B, Rodenstein D, Perrin C, Leger P, Pepin JL, Janssens JP, Gonzalez-Bermejo J; SomnoNIV Group. Ventilatory modes. What's in a name? Respir Care. 2012;57:2138-9;

6- Pépin JL, Tamisier R, Baguet JP, Lévy P. Arterial health is related to obstructive sleep apnea severity and improves with CPAP treatment. Sleep Med Rev. 2013;17:3-5.

7- Baguet JP, Boutin I, Barone-Rochette G, Levy P, Tamisier R, Pierre H, Boggetto-Graham L, Pépin JL. Hypertension diagnosis in obstructive sleep apnea: Self or 24-hour ambulatoryblood pressure monitoring? Int J Cardiol. 2012 Nov 21.doi:pii: S0167-5273(12)01498-2. 10.1016/j.ijcard.2012.11.037. [Epub ahead of
print] PubMed PMID: 23176771.

8- Pépin JL, Tamisier R, Lévy P. Obstructive sleep apnoea and metabolic syndrome: put CPAP efficacy in a more realistic perspective. Thorax. 2012;67:1025-7

9- Gautier E, Arnaud C, Bäck M, Pépin JL, Petri MH, Baguet JP, Tamisier R, Lévy P, Stanke-Labesque F. Intermittent hypoxia activated cyclooxygenase pathway: role in atherosclerosis. Eur Respir J. 2012 Oct 11. [Epub ahead of print] PubMed PMID:23060635.

10- Baguet JP, Barone-Rochette G, Tamisier R, Levy P, Pépin JL. Mechanisms of cardiac dysfunction in obstructive sleep apnea. Nat Rev Cardiol. 2012;9:679-88.

11- Fauroux B, Pepin JL, Boelle PY, Cracowski C, Murris-Espin M, Nove-Josserand R, Stremler N, Simon T, Burgel PR. Sleep quality and nocturnal hypoxaemia and hypercapnia in children and young adults with cystic fibrosis. Arch Dis Child.2012 ;97:960-6

12- Dauvilliers Y, Jaussent I, Krams B, Scholz S, Lado S, Levy P, Pepin JL. Non-dipping blood pressure profile in narcolepsy with cataplexy. PLoS One. 2012;7:e38977.

13- Stanke-Labesque F, Pépin JL, de Jouvencel T, Arnaud C, Baguet JP, Petri MH, Tamisier R, Jourdil JF, Lévy P, Bäck M. Leukotriene B4 pathway activation and atherosclerosis in obstructive sleep apnea. J Lipid Res. 2012;53:1944-51.

14- Minet C, Vivodtzev I, Tamisier R, Arbib F, Wuyam B, Timsit JF, Monneret D, Borel JC, Baguet JP, Lévy P, Pépin JL. Reduced six-minute walking distance, high fat-free-mass index and hypercapnia are associated with endothelial dysfunction in COPD. Respir Physiol Neurobiol. 2012;183:128-34.

15- Krivec U, Quéra Salva MA, Constant I, Ramirez A, Lofaso F, Pépin JL, Fauroux B. Nocturnal hypoxemia, but not hypercapnia, correlates with sleep quality in children. Respir Care. 2012;57:1937-44

16- Roche F, Pépin JL, Achour-Crawford E, Tamisier R, Pichot V, Celle S, Maudoux D, Chouchou F, Ntougou-Assoumou HG, Lévy P, Barthélémy JC; PROOF Study Group. At 68 years, unrecognised sleep apnoea is associated with elevated ambulatory blood pressure. Eur Respir J. 2012;40:649-56

17- Nespoulet H, Wuyam B, Tamisier R, Saunier C, Monneret D, Remy J, Chabre O, Pépin JL, Lévy P. Altitude illness is related to low hypoxic chemoresponse and low oxygenation during sleep. Eur Respir J. 2012;40:673-80.

18- Pépin JL, Guillot M, Tamisier R, Lévy P. The upper airway resistance syndrome. Respiration. 2012;83:559-66.

19- Lévy P, Pépin JL, Dematteis M. Pharyngeal neuropathy in obstructive sleep apnea: where are we going? Am J Respir Crit Care Med. 2012;185:241-3.

20- Levy P, Tamisier R, Arnaud C, Monneret D, Baguet JP, Stanke-Labesque F, Dematteis M, Godin-Ribuot D, Ribuot C, Pepin JL. Sleep deprivation, sleep apnea and cardiovascular diseases. Front Biosci (Elite Ed). 2012;4:2007-21.

11- Baguet JP, Boggetto-Graham L, Thony F, Barone-Rochette G, Rodière M, Pépin JL, Pierre H, Baguet S, Ormezzano O, Vautrin E, Chavanon O. Blood pressure remains too high after a type A aortic dissection or haematoma. Int J Cardiol. 2012;155:307-8.

22- Borel JC, Borel AL, Monneret D, Tamisier R, Levy P, Pepin JL. Obesity hypoventilation syndrome: from sleep-disordered breathing to systemic comorbidities and the need to offer combined treatment strategies. Respirology. 2012;17:601-10.

23- Adler D, Perrig S, Takahashi H, Espa F, Rodenstein D, Pépin JL, Janssens JP. Polysomnography in stable COPD under non-invasive ventilation to reduce patient-ventilator asynchrony and morning breathlessness. Sleep Breath. 2012;16:1081-90.

24- Contal O, Adler D, Borel JC, Espa F, Perrig S, Rodenstein D, Pépin JL, Janssens JP. Impact of different backup respiratory rates on the efficacy of noninvasive positive pressure ventilation in obesity hypoventilation syndrome: a randomized trial. Chest. 2013;143:37-46.

25- Contal O, Carnevale C, Borel JC, Sabil A, Tamisier R, Lévy P, Janssens JP, Pépin JL. Pulse transit time as a measure of respiratory effort under noninvasive ventilation. Eur Respir J. 2013 ;41:346-53.

Other laboratory Members
Title MD First Name Anne-Laure Last Name BOREL E-Mail  
Title MD First Name Jean-Luc Last Name CRACOWSKI E-Mail  
Title MD First Name Marie Last Name DESTORS E-Mail  
Title MD First Name Patrice Last Name FAURE E-Mail  
Title MD First Name Rita Last Name GUZUN E-Mail  
Title MD First Name Sandrine Last Name LAUNOIS E-Mail  
First Name Patrick Last Name LEVY E-Mail  
Title MD First Name Natalia Last Name SIYANKO E-Mail  
First Name Françoise STANKE-LABESQUE Last Name STANKE-LABESQUE E-Mail  
Title MD First Name Renaud TAMISIER Last Name TAMISIER E-Mail  
Title MD First Name Isabelle Last Name VIVODTZEV E-Mail  
Past Members