European Sleep Research Laboratories

Unitat de Son (US)

Hosp. Unv. Arnau de Vilanova - Hosp. Santa Maria
Respiratory Department


Ferran Barbe
Alcalde Rovira Roure 44
25198 Lleida Spain


Position Head of Respiratory Department Phone 973 727222 Fax 0 Contact E-Mail febarbe.lleida.ics@gencat.cat   Research Domain
  • Clinical
  • Basic Human

Keywords
  • Molecular Biology-Endocrinology-Biochemistry
  • Sleep and Medical Disorders
  • Epidemiology of Sleep

Laboratory Description Our area of expertise is cardiovascular problems in OSA patients.
We are interested to evaluate de effect of OSA in the incidence of cardiovascular disease and to evaluate different therapeutic options. To this end we use telemonitoring systems and epidemiological tours.
We study the pathogenic mechanism that relates OSA to metabolic disturbances and cardiovascular problems.
We study biological markers related to oxidative stress, sympathetic activation endothelial dysfunction and inflammation. We also investigate the molecular and genetic bases and susceptibility of those alterations in OSA patients

Technical Capabilities and areas of expertise
Polysomnographic
Non invasive mechanical ventilation
Ambulatory monitoring blood pressure
Actigraphy
ELISA
RT-PCR
Genotyping
MicroRNA profile characterization


Additional Descriptors, Keywords obstruction sleep
cardiovascular risk
stroke
acute myocardial infarction
metabolism

Selected Publications in the 5 past years 1. Riha RL, Diefenbach K, Jennum P, McNicholas WT; Management Committee, COST B26 Action on Sleep Apnoea Syndrome. Genetic aspects of hypertension and metabolic disease in the obstructive sleep apnoea-hypopnoea syndrome. Sleep Med Rev. 2008 Feb;12 (1):49-63. .PMID: 18201663

2. Roure N, Gomez S, Mediano O, Duran J, Peña MD, Capote F, Teran J, Masa JF, Alonso ML, Corral J, Sánchez-Armengod A, Martinez C, Barceló A, Gozal D, Marín JM, Barbé F. Daytime sleepiness and polysomnography in obstructive sleep apnea patients. Sleep Med. 2008 Oct;9(7):727-31. Epub 2008 May 15May 13. PMID: 18482866

3. Alonderis A, Barbé F, Bonsignore M, Calverley P, De Backer W, Diefenbach K, Donic V, Fanfulla F, Fietze I, Franklin K, Grote L, Hedner J, Jennum P, Krieger J, Levy P, McNicholas W, Montserrat J, Parati G, Pascu M, Penzel T, Riha R, Rodenstein D, Sanna A, Schulz R, Sforza E, Sliwinski P, Tomori Z, Tonnesen P, Varoneckas G, Zielinski J, Kostelidou K;. Medico-legal implications of sleep apnoea syndrome: Driving license regulations in Europe. Sleep Med. 2008 May; 9(4):362-75. Epub 2007 Aug 31 PMID: 17765641

4. Barceló A, Barbé F, de la Peña M, Martinez P, Soriano JB, Pierola J, Agusti AG. Insulin Resistance And Daytime Sleepiness In Patients With Sleep Apnea. Thorax. 2008 Nov; 63 (11) 939-40 [Epub ahead of print] PMID: 18535117

5. Egea C, Pinto J, Ayuela J, Ballester E, Zamarrón C, Sojo A, Barbé F. Cardiac function improvement with CPAP therapy in patients with chronic heart failure and sleep apnoea. Sleep Med 2008 Aug;9(6):660-6. PMID: 17904420

6. Barceló A, Barbé F, de la Peña M, Pons J, Rimbau E, Agusti A GN. Endothelial Function and Circulating Endothelial Progenitor Cells in Patients with Sleep Apnea Syndrome. Respiration. 2008;76(1):28-32. [Epub ahead of print] PMID: 17921670

7. Roure N, Mediano O, Duran J, García-Rio F, de la Peña M, Capote F, Terán J, Masa JF, Gozal D, Barbé F. Influencia del sexo en las variables clinicas y polisomnográficas del síndrome de apneas del sueño. Arch Bronconeumol 2008 Dec;44(12) 685-688 PMID.19091238

8. Carrera M, Marín JM, Antón A, Chiner E, Alonso ML, Masa JF, Marrades R, Sala E, Carrizo S, Giner J, Gomez-Merino E, Teran J, Disdier C, Agustí AG, Barbé F.A controlled trial of noninvasive ventilation for chronic obstructive pulmonary disease exacerbations.J Crit Care. Sep;24(3);473.e7-14. Epub 2009 Jan 17 . [Epub ahead of print] PMID: 19327308

9. Durán Alama JM, Vilá Justribó M, Barbé Illa F.A New Case of Idiopathic Bronchiolocentric Interstitial Pneumonia.]Arch Bronconeumol. Jul;45(7):356-7. Epub 2009 Apr 29.2009 Apr 27. [Epub ahead of print] Spanish. PMID: 19403221
10. Martinez-Garcia MA, Soler-Cataluña JJ, Ejarque-Martinez L, Soriano Y, Román-Sánchez P, Barbé Illa F, Montserrat Canal JM, Durán-Cantolla J. CPAP Treatment Reduces Mortality in Ischemic Stroke Patients with Obstructive Sleep Apnea. Am J Respir Crit Care Med. 2009 Jul 1;180(1):36-41. Epub 2009 Apr 30. PMID: 19406983

11. Durán-Cantolla J, Aizpuru F, Martínez-Null C, Barbé-Illa F. Obstructive sleep apnea/hypopnea and systemic hypertension. Sleep Med Rev. 2009 Jun 9. Sleep Med Rev. 2009 Oct;13(5):323-31. Epub 2009 Jun 9.PMID: 19515590 [PubMed - in process]

12. Barbé F, Duran-Cantolla J, Capote F, de la Peña M, Chiner E, Masa Juan F, González M, Marin Jose M, García-Río F, Diaz-de-Atauri J, Teran J, Mayos M, Monastèrio C, del Campo F, Gómez S, Sanchez-de-la-Torre M, Martínez M, Montserrat Jose M. Long-term effect of continuous positive airway pressure in hypertensive patients with sleep apnoea. Am J Respir Crit Care Med. 2009. PMID: 20007932.

13. Sánchez-de-la-Torre M , Pierola J, Vidal C, Barceló A, de la Peña M, Hussain Z, Capote F, Durán J, Alvar GN A, Esquinas C, de Lecea L, Barbé, F.TÍTULO: Non-synonymous polymorphism in the neuropeptide S precursor gene and sleep apnea. Artículo. Abril 2010. Sleep and Breathing. PMID:20405330.

14. Spanish Group of Breathing Sleep Disorders, Masa JF, Jiménez A, Durán J, Carmona C, Monasterio C, Mayos M, Terán J, Barbé F, Rubio M, Failde I, Mota M, Montserrat JM Visual analogical well-being scale for sleep apnea patients: validity and responsiveness : A test for clinical practice. Sleep Breath. 2010 Aug 5. [Epub ahead of print]PMID: 20686860. 2011 Sep;15(3):549-59. Epub 2010 Aug 5.

15. Sánchez-de-la-Torre M, Pierola J, Vidal C, Barceló A, de la Peña M, Hussain Z, Capote F, Durán J, Agustí AG, de Lecea L, Torres G, Esquinas C, Martinez M, Barbé F. Non-synonymous polymorphism in the neuropeptide S precursor gene and sleep apnea. Sleep Breath. 2010 Apr 21. [Epub ahead of print]PMID: 20405330 [PubMed - as supplied by publisher]

16. .Durán-Cantolla J, Aizpuru F, Montserrat JM, Ballester E, Terán-Santos J, Aguirregomoscorta JI, Gonzalez M, Lloberes P, Masa JF, De La Peña M, Carrizo S, Mayos M, Barbé F; Spanish Sleep and Breathing Group. Continuous positive airway pressure as treatment for systemic hypertension in people with obstructive sleep apnoea: randomised controlled trial. BMJ. 2010 Nov 24;341:c5991. doi: 10.1136/bmj.c5991.PMID: 21106625

17. Barceló A, Piérola J, de la Peña M, Esquinas C, Fuster A, Sanchez M, Carrera M, Alonso-Fernandez A, Ladaria A, Bosch M, Barbé F. Eur Respir J. 2010 Dec 23. Free fatty acids and the metabolic syndrome in patients with obstructive sleep apnoea [Epub ahead of print]PMID: 21177837


18. Mediano O, Barbé F.Arch Bronconeumol. 2011 Jan; 47(1):1-2. Does Minimally Symptomatic Sleep Apnea Constitute a Cardiovascular Risk Factor? Epub 2010 Dec 28. English, Spanish. No abstract available. PMID: 21190769

19. Fietze I, Penzel T, Alonderis A, Barbe F, Bonsignore MR, Calverly P, De Backer W, Diefenbach K, Donic V, Eijsvogel MM, Franklin KA, Gislason T, Grote L, Hedner J, Jennum P, Lavie L, Lavie P, Levy P, Lombardi C, Mallin W, Marrone O, Montserrat JM, Papathanasiou ES, Parati G, Plywaczewski R, Riha RL, Rodenstein D, Saaresranta T, Schulz R, Sliwinski P, Steiropoulos P, Svaza J, Tomori Z, Tonnesen P, Varoneckas G, Verbraecken J, Vesely J, Vitols A, Zielinski J, McNicholas WT; COST Action B26 Group. Management of obstructive sleep apnea in Europe. Sleep Med. 2011 Feb;12(2): 190-7. Epub 2010 Dec 16. PMID: 21167776

20. .Zito A, Steiropoulos P, Barceló A, Marrone O, Esquinas C, Buttacavoli M, Barbé F, Bonsignore MR. Obstructive sleep apnoea and metabolic syndrome in Mediterranean countries Eur Respir J. 2011 Mar;37(3):717-9. No abstract available. PMID: 21357928


21. Kuna ST, Badr MS, Kimoff RJ Kushida C, Lee-Chiong T, Levy P, McNicholas WT, Strollo PJ Jr; An official ATS/AASM/ACCP/ERS workoshop report: Research in ambulatory management of adults with obstructive sleep apnea. ATS/AASM/ACCP/ERS Committee on Ambulatory Manegement of Adults with OSA. Proc. Am Thorac Soc.

22. Hedner J, Grote L, Bonsignore M, McNicholas W, Lavie P, Parati G, Sliwinski P, Barbé F, De Backer W, Escourrou P, Fietze I, Kvamme JA, Lombardi C, Marrone O, Masa JF, Montserrat JM, Penzel T, Pretl M, Riha R, Rodenstein D, Saaresranta T, Schulz R, Tkacova R, Varoneckas G, Vitols A, Vrints H, Zielinski J. The European Sleep Apnoea Database (ESADA): report from 22 European sleep laboratories. Eur Respir J. 2011 Sep;38(3):635-42. Epub 2011 May 26. PMID: 21622583

23. Andreu AL, Chiner E, Sancho-Chust JN, Pastor E, Llombart M, Gomez-Merino E, Senent C, Barbé F. Effect of an ambulatory diagnostic and treatment program in patients with Sleep Apnoea. Eur Respir J. 2011 Jul 7. [Epub ahead of print] [PubMed - as supplied by publisher] 2012 Feb;39(2):305-12. Epub 2011 Jun 30 . PMID: 21719490

24. Montserrat JM, Rodenstein D, Barbé F. Effects of CPAP on daytime function.Sleep. 2011 Jul 1;34(7):821; author reply 823, 825. No abstract available. PMID: 21731123


25. Barceló A, Piérola J, de la Peña M, Esquinas C, Sanchez-de la Torre M, Ayllón O, Alonso A, Agusti AG, Barbè F. Day- night variations in endothelial dysfunction markers and haemostatic factors in sleep apnoea. Eur Respir J. 2011 Aug 18. [Epub ahead of print]
2012 Apr;39(4):913-8. Epub 2011 Aug 18.PMID: 21852330

26. Cano-Pumarega I, Durán-Cantolla J, Aizpuru F, Miranda-Serrano E, Rubio R, Martínez-Null C, de Miguel J, Egea C, Cancelo L, Alvarez A, Fernández-Bolaños M, Barbé F. Obstructive sleep apnea and systemic hypertension: longitudinal study in the general population: the vitoria sleep cohort. Am J Respir Crit Care Med. 2011 Dec 1;184(11):1299-304. Epub 2011 Aug 25. PMID: 21868499

27. Piérola J, Alemany A, Yañez A, de-la-Peña M, Sánchez-de-la-Torre M, Esquinas C, Pérez-Gutierrez C, Burguera B, Barbé F, Barceló A. NADPH oxidase p22phox polymorphisms and oxidative stress in patients with obstructive sleep apnoea.Respir Med. 2011 Nov;105(11):1748-54. Epub 2011 Aug 27.PMID: 21872458


28. Agusti A, Hedner J, Marin JM, Barbé F, Cazzola M, Rennard S. Night-time symptoms: a forgotten dimension of COPDEur Respir Rev. 2011 Sep 1;20(121):183-94. Review. PMID: 21881146

29. Sánchez-de-la-Torre M, Barceló A, Piérola J, Esquinas C, de la Peña M, Durán-Cantolla J, Capote F, Masa JF, Marin JM, Vilá M, Cao G, Martinez M, de Lecea L, Gozal D, Montserrat JM, Barbé F. Plasma levels of neuropeptides and metabolic hormones, and sleepiness in obstructive sleep apnea. Respir Med. 2011 Dec;105(12):1954-60. Epub 2011 Sep 1. PMID: 21889324

30. Sánchez-de-la-Torre M, Mediano O, Barceló A, Piérola J, de la Peña M, Esquinas C, Miro A, Durán-Cantolla J, Agustí AG, Capote F, Marin JM, Montserrat JM, García-Río F, Barbé F. The influence of obesity and obstructive sleep apnea on metabolic hormones. Sleep Breath. 2011 Sep 13. [Epub ahead of print] PMID: 21912907

31. Bonsignore MR, Esquinas C, Barceló A, Sanchez-de-la-Torre M, Paternó A, Duran-Cantolla J, Marín JM, Barbé F. Metabolic syndrome, insulin resistance and sleepiness in real-life obstructive sleep apnoea. Eur Respir J. 2011 Nov 10. [Epub ahead of print] PMID: 22075482

32. Muñoz R, Durán-Cantolla J, Martinez-Vila E, Gállego J, Rubio R, Aizpuru F, De La Torre G, Barbé F. Central sleep apnea is associated with increased risk of ischemic stroke in the elderly. Acta Neurol Scand. 2011 Dec 9. doi: 10.1111/j.1600-0404.2011.01625.x. [Epub ahead of print] PMID: 22150745

33. Ferran Barbé, MD; Joaquín Durán-Cantolla, MD; Manuel Sánchez-de-la-Tore, Phd; Montserrat Martínez-Alonso, BSc(Stat); Carmen Carmona, MD; Antonia Barceló, MD; Eusebi Chiner, MD; Juan F.Masa, MD; Mónica Gonzalez, MD; JoseM.Marín, MD; Francisco Garcia-Rio; MD; Josefa Diaz de Atauri, MD; Joaquín Terán, MD; Mercedes Mayos, MD; Mónica de la Peña, MD; Carmen Monasterio, MD; Felix del Campo; MD; Josep M. Montserrat, MD; for the Spanish Sleep an Breathing Network. Effect of Continuous Positive Airway Pressure on the Incidente of hipertension and Cardiovascular Events in Nonsleepy Patients With Obstructive Sleep Apnea: Title and subTitle BreakA Randomized Controllet TrialCpap and Hypertension and Cardiovascular Events. Jama.2012; 307(20)2161-2168. doi: 10.1001/jama.2012.4366. PMID22618923

34. José M.Marin, MD; Alvar Agusti, MD; Isabel Villar, PhD; Marta Forner; PhD; David Nieto, MD; Santiago J.Carrizo, MD; Ferran Barbé, MD; Eugenio Vicente, MD; Ying Wei, PhD; F. Javier Nieto, MD, PhD; Sanja Jelic, MD. Association Between Treated and Untreated Obstructive Sleep Apnea and Risk of Hipertension Obstructive Sleep Apnea and Risk of Hypertension. JAMA. 2012;307(20):2169-2176.doi:10.1001/jama.2012.3418. PMID 22618924

35. Sánchez-de-la-Torre, M; Campos-Rodriguez F; Barbé F. Obstructive sleep apnoea and cardiovascular disease. The Lancet Respiratory Medicine, Volume 1, Issue 1, Pages 61 - 72, March 2013. 10.1016/S2213-2600(12)70051-6

36. Muniesa M, Sánchez-de-la-Torre M, Huerva V, Lumbierres M, Barbé F Floppy Eyelid Syndrome as an Indicator of the Presence of Glaucoma in Patients With Obstructive Sleep Apnea. J Glaucoma. 2013 Jun 25. [Epub ahead of print]PMID: 23807350 [PubMed -as supplied by publisher]

37. Chiner E, Andreu AL, Sancho-Chust JN, Sánchez-de-la-Torre A, Barbé FThe use of ambulatory strategies for the diagnosis and treatment of obstructive sleep apnea in adults. Expert Rev Respir Med. 2013 Jun;7(3):259-73. doi: 10.1586/ers.13.19.PMID: 23734648 [PubMed - in process]

38. Muniesa MJ, Huerva V, Sánchez-de-la-Torre M, Martínez M, Jurjo C, Barbé F. The relationship between floppy eyelid syndrome and obstructive sleep apnoea.Br J Ophthalmol. 2013 Apr 12. [Epub ahead of print] PMID: 23584721 [PubMed - as supplied by publisher.

39. Barbé F, Masa JF. Hypoglossal neurostimulation for obstructive sleep apnoea. Eur Respir J. 2013 Feb;41(2):257-8. doi: 10.1183/09031936.00132312. No abstract available. PMID: 23370799


Key Publications of the Laboratory 1. Durán-Cantolla J, Aizpuru F, Montserrat JM, Ballester E, Terán-Santos J, Aguirregomoscorta JI, Gonzalez M, Lloberes P, Masa JF, De La Peña M, Carrizo S, Mayos M, Barbé F; Spanish Sleep and Breathing Group. Continuous positive airway pressure as treatment for systemic hypertension in people with obstructive sleep apnoea: randomised controlled trial. BMJ. 2010 Nov 24;341:c5991. doi: 10.1136/bmj.c5991.PMID: 21106625

2. Cano-Pumarega I, Durán-Cantolla J, Aizpuru F, Miranda-Serrano E, Rubio R, Martínez-Null C, de Miguel J, Egea C, Cancelo L, Alvarez A, Fernández-Bolaños M, Barbé F. Obstructive sleep apnea and systemic hypertension: longitudinal study in the general population: the vitoria sleep cohort. Am J Respir Crit Care Med. 2011 Dec 1;184(11):1299-304. Epub 2011 Aug 25. PMID: 21868499

3. Ferran Barbé, MD; Joaquín Durán-Cantolla, MD; Manuel Sánchez-de-la-Tore, Phd; Montserrat Martínez-Alonso, BSc(Stat); Carmen Carmona, MD; Antonia Barceló, MD; Eusebi Chiner, MD; Juan F.Masa, MD; Mónica Gonzalez, MD; JoseM.Marín, MD; Francisco Garcia-Rio; MD; Josefa Diaz de Atauri, MD; Joaquín Terán, MD; Mercedes Mayos, MD; Mónica de la Peña, MD; Carmen Monasterio, MD; Felix del Campo; MD; Josep M. Montserrat, MD; for the Spanish Sleep an Breathing Network. Effect of Continuous Positive Airway Pressure on the Incidente of hipertension and Cardiovascular Events in Nonsleepy Patients With Obstructive Sleep Apnea: Title and subTitle BreakA Randomized Controllet TrialCpap and Hypertension and Cardiovascular Events. Jama.2012;307(20)2161-2168. doi: 10.1001/jama.2012.4366

4. José M.Marin, MD; Alvar Agusti, MD; Isabel Villar, PhD; Marta Forner; PhD; David Nieto, MD; Santiago J.Carrizo, MD; Ferran Barbé, MD; Eugenio Vicente, MD; Ying Wei, PhD; F. Javier Nieto, MD, PhD; Sanja Jelic, MD. Association Between Treated and Untreated Obstructive Sleep Apnea and Risk of Hipertension Obstructive Sleep Apnea and Risk of Hypertension. JAMA. 2012;307(20):2169-2176.doi:10.1001/jama.2012.3418

5. Sánchez-de-la-Torre, M; Campos-Rodriguez F; Barbé F. Obstructive sleep apnoea and cardiovascular disease. The Lancet Respiratory Medicine, Volume 1, Issue 1, Pages 61 - 72, March 2013. 10.1016/S2213-2600(12)70051-6

Current/Completed Grants (past 5 years) 1. Spanish Institute for Research in Health Social Security Fund for Scientific Research (FISss). Intermittent positive pressure nasal ventilation in hypercapnic respiratory insufficiency . 1990 Ref 90/208
2. Social Security Fund for Scientific Research (FISss). Prognostic value of the biochemistry of pleural liquid in neoplasic efflusions. 1990 Ref 90/423
3. Social Security Fund for Scientific Research (FISss). Ventilatory support (BiPAP) in exacerbated chronic obstructive pulmonary disease. Principal investigator. 1993 Ref 93/0860
4. Social Security Fund for Scientific Research (FISss). Effects of non-invasive ventilatory assistance via BiPAP on the post-op for thoracic surgery. Collaborating investigator. 1993 Ref 93/0855
5. Spanish Society for Pneumology and Thoracic Surgery (SEPAR). Obstructive sleep apnea syndrome. Cellular biology of treatment with CPAP. Associate investigator 1994.
6. Catalan Pneumology Foundation (FUCAP). Obstructive sleep apnea syndrome. Cellular biology of treatment with CPAP. Collaborating investigator. 1994.
7. Spanish Society for Pneumology and Thoracic Surgery (SEPAR). Dynamic hyperinsuflation, auto-peep and diaphragmatic function in patients with chronic obstructive pulmonary disease. Differential role of the sympathetic and parasympathetic nervous system. Collaborating investigator. 1994.
8. Social Security Fund for Scientific Research (FIS 95/1510). Functional in vitro study of the musculature of the upper airway in patients with sleep apnea syndrome. Collaborating investigator. 1995
9. Spanish Society for Pneumology and Thoracic Surgery (SEPAR). Tolerance and response to exercise in patients with sleep apnea syndrome. Physiological effects of treatment with CPAP. Associate investigator. 1995
10. Spanish Society for Pneumology and Thoracic Surgery (SEPAR). Compliance with CPAP treatment. Associate investigator. 1995
11. Catalan Pneumology Foundation (FUCAP). Genetic basis of the cardiovascular pathology of sleep apnea. Collaborating investigator. 1995
12. Academy of Medical Sciences of Catalonia and the Balearic Islands. Sleep apnea syndrome and cardiovascular pathology. Genetic basis. Collaborating investigator. 1995
13. Social Security Fund for Scientific Research (FIS 96/1718)). Cardiovascular pathology and sleep apnea syndrome. Collaborating investigator. 1996
14. Social Security Fund for Scientific Research (FIS 97/0875). Exhaled nitric oxide in the sleep apnea syndrome. Principal investigator. 1997
15. Social Security Fund for Scientific Research (FIS 98/0055-04). Effects of CPAP on mild-moderate OSAS. Principal investigator. Coordinated project.
16. Social Security Fund for Scientific Research (FIS 99/0032-01). Effects of treatment with CPAP in paucisymptomatic patients with moderate-to-severe OSAHS. Principal investigator.
17. Spanish Society for Pneumology and Thoracic Surgery (SEPAR). Effects of treatment with CPAP in paucisymptomatic patients with moderate-to-severe OSAHS. Principal investigator. 1999
18. Spanish Society for Pneumology and Thoracic Surgery (SEPAR). Cognitive evaluation and traffic accidents in patients with OSAHS. Assessor. 1999
19. Spanish Society for Pneumology and Thoracic Surgery (SEPAR). Study of the involvement of the orexin receptor 2 in the molecular etiopathogeny of the sleep apnea syndrome. Principal investigator. 2000.
20. Spanish Society for Pneumology and Thoracic Surgery (SEPAR). Biological aspects of the sleep apnea syndrome. Relationship with obesity and sleepiness. Principal investigator 2001.
21. Social Security Fund for Scientific Research (FIS 01/0786). Study of the involvement of the orexin receptor 2 in the molecular etiopathogeny of the sleep apnea syndrome. Principal investigator 2001.
22. Social Security Fund for Scientific Research (FIS 01/0109-05). Multicenter, randomized, simple blind study with parallel groups controlled with placebo, to evaluate the efficacy of CPAP treatment in stable cardiac insufficiency and sleep-related respiratory disorders. Collaborating investigator.
23. Social Security Fund for Scientific Research (FIS 01/0025-02). Usefulness of the empirical and automatic adjustment of CPAP in the sleep apnea-hypoapnea syndrome. Collaborating investigator.
24. Social Security Fund for Scientific Research (FIS 02/0334). Biological markers in the sleep apnea syndrome. Relationship with obesity and daytime sleepiness. Collaborating investigator.
25. Spanish Society for Pneumology and Thoracic Surgery (SEPAR). Treatment with nasal CPAP in paucisymptomatic patients with sleep apnea-hypoapnea syndrome. Effect on cardiovascular morbidity-mortality. Principal investigator 2004.
26. Spanish Society for Pneumology and Thoracic Surgery (SEPAR). Circulating endothelial cells in patients with sleep apnea syndrome. Implications for cardiovascular risk. Collaborating investigator 2004.
27. Social Security Fund for Scientific Research. (PI 040165). Effect of treatment with CPAP on the incidence of systemic hypertension and cardiovascular morbidity-mortality in patients with sleep apnea syndrome without daytime sleepiness. Collaborating investigator. 2004.
28. Social Security Fund for Scientific Research. (PI 041593). Molecular and cellular basis of vascular, pulmonary and systemic damage associated with situations of continuous intermittent hypoxia: implications for chronic obstructive pulmonary disease and sleep apnea syndrome. Principal investigator. 2004.
29. Fundació Marató TV3. Circulating endothelial progenitor cells in patients with sleep apnea syndrome. Principal investigator. 2004.
30. Spanish Society for Pneumology and Thoracic Surgery (SEPAR). The pathogeny of obesity in sleep apnea syndrome. Collaborating investigator 2005.
31. Social Security Fund for Scientific Research. (PI 070585). Sleep apnea syndrome and the pathogeny of obesity. Principal investigator. 2007
32. Social Security Fund for Scientific Research. (PI 070598). Daytime sleepiness, sympathetic activity and hypertension in patients with sleep apnea-hypoapnea syndrome. Collaborating investigator. 2007
33. Spanish Society for Pneumology and Thoracic Surgery (SEPAR). Daytime sleepiness, sympathetic activity and hypertension in patients with sleep apnea-hypoapnea syndrome. Principal investigator 2007
34. Catalan Hypertension Society. Daytime sleepiness, sympathetic activity and hypertension in patients with sleep apnea-hypoapnea syndrome. Principal investigator. 2008
35. Catalan Pneumology Society. Daytime sleepiness, sympathetic activity and hypertension in patients with sleep apnea-hypoapnea syndrome. Principal investigator. 2008.
36. Social Security Fund for Scientific Research (ETES) 2009 Diagnosis of the sleep apnea-hypoapnea syndrome (SAHS) by voice analysis (DISAVOZ). PI09/91004.
37. Spanish Society for Pneumology and Thoracic Surgery. Effect of treatment on the sympathetic activity, metabolic activity and inflammatory activity in morbidly obese patients with sleep apnea. Collaborating investigator. 2009-2011
38. Social Security Fund for Scientific Research. Impact of the sleep apnea-hypoapnea syndrome on the evolution of the acute coronary syndrome. Effect of the intervention with continuous positive airway pressure (CPAP). Randomized prospective study. ISAACC study. 2011-2013
39. ResMed Fundation. Impact of sleep apnea-hypopnea syndrome (SAHS) on the evolution of acute coronary syndrome. Effect of intervention with continuous positive airway pressure (CPAP). Randomized controlled trial. ISAACC study.

40. Monitoring of OSA in sleep specialist units and in primary care. Equivalence randomized comparative study on compliance and clinical response in patients with sleep apnea-hypopnea syndrome (SAHS)" PI12/01499. 2013-2015

 
Other laboratory Members
 
Title MD First Name Anunciación Last Name Cortijo Fernandez E-Mail acortijo@gss.scs.es  
Title MD First Name Elena Last Name Forcen Vera E-Mail elenaforcen@hotmail.com  
First Name Juan Ramon Last Name Rozadilla Secanell E-Mail jrrozadilla@gss.scs.es  
First Name Gerard Last Name Torres Cortada E-Mail gtorres@gss.scs.es  
First Name Xavier Last Name Galindo Ortego E-Mail xgalindo@gss.scs.es  
Title MD First Name Maite Last Name Utges Nogues E-Mail mutges@comll.cat  
Title MD First Name Sandra Last Name Serra Torrecillas E-Mail sserra@gmail.com  
Title MD First Name Manuel Last Name Cervera del Pino E-Mail mcervera@gss.scs.es  
Title MD First Name Silvia Last Name Gomez Falguera E-Mail sgfalguera@gmail.com  
Title MD First Name Marina Last Name Lumbierres Burgues E-Mail mlumbierres@yahoo.es  
Collaborations
 
 
Past Members