European Sleep Research Laboratories

Sleep Laboratory of Tampere University Hospital

Medical Imaging Centre and Hospital Pharmacy
Dept. of Clinical Neurophysiology


Sari-Leena Himanen
PO Box 2000
33521 Tampere Finland


Position Chief Physician Phone +358 3 31167578 Fax +358 3 31164352 Contact E-Mail sari-leena.himanen@pshp.fi   Research Domain
  • Clinical
  • Methodology / Technology

Keywords
  • Neurological Sleep Disorders
  • Paediatric Sleep Disorders
  • Sleep Physiology-Neurophysiology in Human
  • Sleep and Body Functions (Cardio-Respiratory, Thermoregulation/Metabolism, Endocrine)
  • Sleep and Medical Disorders
  • Learning, Memory, Cognition

Laboratory Description Sleep mattress, snoring
Technical Capabilities and areas of expertise Automatic analysis of sleep EEG and breathing sounds.
Additional Descriptors, Keywords Emfit
Selected Publications in the 5 past years 1. Huupponen E, Saunamäki T, Saastamoinen A, Kulkas A, Himanen SL. Improved computational fronto-central sleep depth parameters show differences between apnea patients and control subjects. Med Biol Eng Comput. 2009;47:3-10.

2. Rauhala E, Virkkala J, Himanen SL. Periodic limb movement screening as an additional feature of Emfit sensor in sleep-disordered breathing studies. J Neurosci Methods. 2009;178:157-61

3. Tenhunen M, Rauhala E, Huupponen E, Saastamoinen A, Kulkas A, Himanen SL. High frequency components of tracheal sound are emphasized during prolonged flow limitation. Physiol Meas. 2009;30:467-478.

4. Kulkas A, Huupponen E, Virkkala J, Tenhunen M, Saastamoinen A, Rauhala E, Himanen SL. New tracheal sound feature for apnoea analysis. Med Biol Eng Comput. 2009;47:405-12.

5. Saunamäki T, Himanen SL, Polo O, Jehkonen M. Executive dysfunction in patients with obstructive sleep apnea syndrome. Eur Neurol. 2009;62:237-42.

6. Saunamäki T, Jehkonen M, Huupponen E, Polo O, Himanen SL. Visual dysfunction and computational sleep depth changes in obstructive sleep apnea syndrome. Clin EEG Neurosci. 2009;40:162-7.

7. Kulkas A, Huupponen E, Virkkala J, Tenhunen M, Saastamoinen A, Rauhala E, Himanen SL. Intelligent methods for identifying respiratory cycle phases from tracheal sound signal during sleep. Comput Biol Med. 2009;39:1000-1005.
8. Virkkala J, Värri A, Hasan J, Himanen SL, Müller K. Sleep stage classification with low complexity and low bit rate. Conf Proc IEEE Eng Med Biol Soc. 2009:2506-9. doi: 10.1109/IEMBS.2009.5335165.

9. Kulkas A, Huupponen E, Virkkala J, Saastamoinen A, Rauhala E, Tenhunen M, Himanen SL. Tracheal sound parameters of respiratory cycle phases show differences between flow-limited and normal breathing during sleep. Physiol Meas 2010:31:427-438.
10. Saunamäki T, Himanen SL, Polo O, Jehkonen M. Executive dysfunction and learning effect after continuous positive airway pressure treatment in patients with obstructive sleep apnea syndrome. Eur Neurol. 2010;63:215-20.
11. Huupponen E, Kulkas A, Saastamoinen A, Tenhunen M, Himanen SL. Identification of deep sleep and awake with computational EEG measures. J Med Syst. 2011;35:1413-20.

12. Tenhunen M, Rauhala E, Virkkala J, Polo O, Saastamoinen A, Himanen SL. Increased respiratory effort during sleep is noninvasively detected with movement sensor. Sleep and Breathing, 2011:15;737-746.
13. Kalleinen N, Virkki A, Polo O, Himanen SL, Irjala K, Joutsen A, Porkka-Heiskanen T, Polo-Kantola P. The temporal relationship between growth hormone and slow wave sleep is weaker after menopause. Sleep Med. 2012;13:96-101.
14. Nohynek H, Jokinen J, Partinen M, Vaarala O, Kirjavainen T, Sundman J, Himanen SL, Hublin C, Julkunen I, Olsén P, Saarenpää-Heikkilä O, Kilpi T. AS03 adjuvanted AH1N1 vaccine associated with an abrupt increase in the incidence of childhood narcolepsy in Finland. PLoS ONE 2012;7: e33536, ss 1-9.

15. Nohynek H, Jokinen J, Partinen M, Vaarala O, Kirjavainen T, Sundman J, Himanen SL, Hublin C, Julkunen I, Olsén P, Saarenpää-Heikkilä O, Kilpi T. AS03 adjuvanted AH1N1 vaccine associated with an abrupt increase in the incidence of childhood narcolepsy in Finland (Finnish). Suomen Lääkärilehti 2012;67:1035-1044.

16. Kaartinen M, Puura K, Mäkelä T, Rannisto M, Lemponen R, Helminen M, Salmelin R, Himanen SL, Hietanen JK. Autonomic Arousal to Direct Gaze Correlates with Social Impairments Among Children with ASD. J Autism Dev Disord 2012;42:1917-27.
17. Guerrero-Mora G, Palacios E, Bianchi AM, Kortelainen J, Tenhunen M, Himanen SL, Mendez MO, Arce-Santana E, Gutierrez-Navarro O. Sleep-wake detection based on respiratory signal acquired through a pressure bed sensor. Conf Proc IEEE Eng Med Biol Soc. 2012;2012:3452-5. doi: 10.1109/EMBC.2012.6346708.

18. Tenhunen M, Elomaa E, Sistonen H, Rauhala E, Himanen SL. Emfit movement sensor in evaluating nocturnal breathing. Respir Physiol Neurobiol, in press.

Key Publications of the Laboratory Himanen SL, Hasan J. Limitations of Rechtschaffen and Kales. Sleep Med Rev 2000;4:149-167.

2. Himanen SL, Virkkala J, Huhtala H, Hasan J. Spindle frequencies in sleep EEG show U-shape within first four NREM sleep episodes. J Sleep Res. 2002;11:35-42.

3. Huupponen E, Himanen SL, Värri A, Hasan J, Lehtokangas M, Saarinen J. A Study on Gender and Age Differences in Sleep Spindles. Neuropsychobiology 2002;45:99-105

4. Himanen SL, Virkkala J, Huupponen E, Hasan J. Spindle frequency remains slow in sleep apnea patients throughout the night. Sleep Medicine 2003;4:361-366.

5. Himanen SL, Joutsen A, Virkkala J. Visual assessment of selected high amplitude frontopolar slow waves of sleep: Differences between healthy subjects and apnea patients. Clin EEG Neurosci 2004;35:125-131.

6. Danker-Hopfe H, Kunz D, Gruber G, Klösch G, Lorenzo JL, Himanen SL, Kemp B, Penzel T, Röschke J, Dorn H, Schlögl A, Trenker E, Dorffner G. Interrater reliability between scorers from eight European sleep laboratories in subjects with different sleep disorders. J Sleep Res 2004;13:63-69.

7. Huupponen E, Saastamoinen A, Niemi J, Virkkala J, Hasan J, Varri A, Himanen SL. Automated Frequency Analysis of Synchronous and Diffuse Sleep Spindles. Neuropsychobiology. 2005;51:256-264.

8.Danker-Hopfe H, Schäfer M, Dorn H, Anderer P, Saletu B, Gruber G, Zeitlhofer J, Kunz D, Barbanoj MJ, Himanen SL, Kemp B, Penzel,T, Röschke J, Dorffner G. Percentile Reference Charts for Selected Sleep Parameters for 20- to 80-Year-Old Healthy Subjects from the SIESTA Database. Somnologie 2005;9:3–14.

9. Huupponen E, Saastamoinen A, Eskelinen V, Värri A, Hasan J, Himanen SL. Apnea patients show a frontopolar inter-hemispheric spindle frequency difference.
Neurosci Lett. 2006 Jul 31;403(1-2):186-9

10. Kalleinen N, Polo O, Himanen SL, Joutsen A, Urrila AS, Polo-Kantola P. Sleep deprivation and hormone therapy in postmenopausal women.
Sleep Med. 2006 Aug;7(5):436-47.

11. Rauhala E, Himanen SL, Saastamoinen A, Polo O. Prolonged spiking in the Emfit sensor in patients with sleep-disordered breathing is characterized by increase in transcutaneous carbon dioxide. Physiol Meas. 2007;28:1163-73.

12. Huupponen E, Gomez-Herrero G, Saastamoinen A, Värri A, Hasan J, Himanen SL. Development and comparison of four sleep spindle detection methods. Artif Intell Med. 2007;40:157-70.

13. Kalleinen N, Polo-Kantola P, Himanen SL, Alhola P, Joutsen A, Urrila AS, Polo O. Sleep and the Menopause – Do postmenopausal women experience worse sleep than premenopausal women? Menopause Int. 2008 Sep;14(3):97-104.

14. Rauhala E, Hasan J, Kulkas A, Saastamoinen A, Huupponen E, Cameron F, Himanen SL. Compressed tracheal sound analysis in screening of sleep-disordered breathing. Clin Neurophysiol. 2008 Sep;119(9):2037-43.

15. Tenhunen M, Rauhala E, Huupponen E, Saastamoinen A, Kulkas A, Himanen SL. High frequency components of tracheal sound are emphasized during prolonged flow limitation. Physiol Meas. 2009;30:467-478.

16. Saunamäki T, Himanen SL, Polo O, Jehkonen M. Executive dysfunction in patients with obstructive sleep apnea syndrome. Eur Neurol. 2009;62:237-42.
17. Saunamäki T, Himanen SL, Polo O, Jehkonen M. Executive dysfunction and learning effect after continuous positive airway pressure treatment in patients with obstructive sleep apnea syndrome. Eur Neurol. 2010;63(4):215-20.

18. Tenhunen M, Rauhala E, Virkkala J, Polo O, Saastamoinen A, Himanen SL. Increased respiratory effort during sleep is noninvasively detected with movement sensor. Sleep and Breathing, 2011:15;737-746.
19. Nohynek H, Jokinen J, Partinen M, Vaarala O, Kirjavainen T, Sundman J, Himanen SL, Hublin C, Julkunen I, Olsén P, Saarenpää-Heikkilä O, Kilpi T. AS03 adjuvanted AH1N1 vaccine associated with an abrupt increase in the incidence of childhood narcolepsy in Finland. PLoS ONE 2012;7: e33536, pages 1-9.
20. Tenhunen M, Elomaa E, Sistonen H, Rauhala E, Himanen SL. Emfit movement sensor in evaluating nocturnal breathing. Respir Physiol Neurobiol, in press.

 
Other laboratory Members
 
Title PhD,MD First Name Joel Last Name Hasan E-Mail joel.hasan@pshp.fi  
Collaborations
 
Past Members