European Sleep Research Laboratories

Service des pathologies du sommeil

Pitié-Salpêtrière University Hospital
Institute for brain and spinal cord

Isabelle Arnulf
47-83 boulevard de l'Hôpital
75651 cede Paris France

Position Professor of neurology Phone +33 1 42 16 77 01 Fax +33 1 42 16 77 00 Contact E-Mail   Research Domain
  • Clinical

  • Neurological Sleep Disorders
  • Sleep and Body Functions (Cardio-Respiratory, Thermoregulation/Metabolism, Endocrine)

Laboratory Description We study the mechanisms of neurological diseases in patients, and view neurological sleep disorders as models to understand normal sleep. We focuse on central hypersomnias (narcolepsy, idiopathic hypersomnia and Kleine Levin syndrome) and parasomnias (RBD and sleepwalking), whether primary or secondary to neurological or genetic diseases. An additional part of the lab studies the control of breathing during sleep. Our tools include clinical investigation (face to face interview, questionaires, dream recall, neurological examination), cognitive tests videopolysomnography (from 24 to 48 h long, including spectral EEG analysis, EOG and EMG analysis), sera, CSF and DNA bank, and pharmacology.
Technical Capabilities and areas of expertise 10 beds (and soon 16 beds) facilities.
Our area of expertise are central hypersomnia, parasomnia and sleep disorders in neurodegenerative disease.

Selected Publications in the 5 past years 1) Arnulf, I., Ferraye, M., Fraix, V., Benabid, A. L., Chabardes, S., Goetz, L., Pollak, P., Debu, B. (2010). Sleep induced by stimulation in the human pedunculopontine nucleus area. Ann Neurol, 67(4), 546-549.

2) Hor, H., Kutalik, Z., Dauvilliers, Y., Valsesia, A., Lammers, G. J., Donjacour, C. E., Iranzo A, Santamaria J, Peraita Adrados R,Vicario JL, Overeem S, Arnulf I, Theodorou I, Jennum P, Knudsen S, Bassetti C, Mathis J, Lecendreux M, Mayer G, Geisler P,Benetó A, Petit B, Pfister C,Vienne Bürki J, Didelot G, Billiard M, Ercilla G, Verduijn W, Claas FHJ, Vollenwider P, Waeber G, Waterworth DM, Mooser V, Heinzer R, Beckmann JS,Bergmann S, Tafti M. (2010). Genome-wide association study identifies new HLA class II haplotypes strongly protective against narcolepsy. Nat Genet, 42(9), 786-789.

3) Leclair-Visonneau, L., Oudiette, D., Gaymard, B., Leu-Semenescu, S., Arnulf, I. (2010). Do the eyes scan dream images during rapid eye movement sleep? Evidence from the rapid eye movement sleep behaviour disorder model. Brain, 133 1737-1746.

4) Leu-Semenescu, S., Arnulf, I., Decaix, C., Moussa, F., Clot, F., Boniol, C., Touitou Y, Levy R, Vidailhet M, Roze E. (2010). Sleep and rhythm consequences of a genetically induced loss of serotonin. Sleep, 33(3), 307-314.

5) Vernet, C., Leu-Semenescu, S., Buzare, M., Arnulf, I. (2010). Subjective symptoms in idiopathic hypersomnia: beyond excessive sleepiness. J Sleep Res, 19(4), 525-534.

6) Redolfi, S, Arnulf, I, Pottier, M, Lajou, J, Koskas, I, Bradley, TD, Similowski, T. (2011)
Attenuation of obstructive sleep apnea by compression stockings in subjects with venous insufficiency.
Am J Respir Crit Care Med, 184 :1062-6

7) Arnulf, I., Brion, A., Pottier, M., & Golmard, J. L. (2011). Ring the bell for Matins: Circadian adaptation to split sleep by cloistered monks and nuns. Chronobiol Int, 28(10), 930-941.

8) Cochen De Cock, V., Debs, R., Oudiette, D., Leu, S., Radji, F., Tiberge, M., Yu H, Bayard S, Roze E, Vidailhet M, Dauvilliers Y, Rascol O, Arnulf I. (2011). The improvement of movement and speech during rapid eye movement sleep behaviour disorder in multiple system atrophy. Brain, 134, 856-862.

9) Lavault, S., Dauvilliers, Y., Drouot, X., Leu-Semenescu, S., Golmard, J. L., Lecendreux, M., Franco P, Arnulf I. (2011). Benefit and risk of modafinil in idiopathic hypersomnia vs. narcolepsy with cataplexy. Sleep Med, 12(6), 550-556.

10) Leu-Semenescu, S., De Cock, V. C., Le Masson, V. D., Debs, R., Lavault, S., Roze, E., et al. (2011). Hallucinations in narcolepsy with and without cataplexy: contrasts with Parkinson's disease. Sleep Med, 12(5), 497-504.

11) Oudiette, D., Constantinescu, I., Lecalir-Visonneau, L., Vidailhet, M., Schwartz, S., Arnulf, I. (2011). Evidence for the re-enactment of a recently learned behavior during sleepwalking. Plos One, 6(3), e18056.

12) Saurat, M. T., Agbakou, M., Attigui, P., Golmard, J. L., Arnulf, I. (2011). Walking dreams in congenital and acquired paraplegia. Conscious Cogn, 20(4), 1425-1432.

13) Vernet, C., Redolfi, S., Attali, V., Konofal, E., Brion, A., Frija-Orvoen, E., Pottier, M. Similowski, T., Arnulf, I. (2011). Residual sleepiness in obstructive sleep apnoea: phenotype and related symptoms. Eur Respir J, 38(1), 98-105.

14) Arnulf, I. (2012). REM sleep behavior disorder: motor manifestations and pathophysiology. Mov Disord, 27(6), 677-689.

15) Arnulf, I., Rico, T., & Mignot, E. (2012). Diagnosis, disease course, and management of patients with Kleine-Levin syndrome. Lancet Neurol, 11, 918-928.

16) Brion, A., Flamand, M., Oudiette, D., Voillery, D., Golmard, J. L., Arnulf, I. (2012). Sleep-related eating disorder versus sleepwalking: a controlled study. Sleep Med, 13(8), 1094-1101.

17) Karroum, E. G., Golmard, J. L., Leu-Semenescu, S., Arnulf, I. (2012). Sensations in restless legs syndrome. Sleep Med, 13(4), 402-408.

18) Oudiette, D., Dealberto, M. J., Uguccioni, G., Golmard, J. L., Merino-Andreu, M., Tafti, M., Garma, L., Schwartz, S.Arnulf, I. (2012). Dreaming without REM sleep. Conscious Cogn, 21(3), 1129-1140.

19) Postuma, R., Montplaisir, J., Pelletier, A., Dauvilliers, Y., Oertel, W., Iranzo, A., Ferini-Strambi, L, Arnulf, I, Hogl, B, Manni, R, Miyamoto, T, Mayer, G, Stiasny-Kolster, K, Puligheddu, M, Ju, Y, Jennum, P, Sonka, K, Santamaria, J, Fantini, ML, Zucconi, M, Leu-Semenescu, S, Frauscher, B, Terzaghi, M, Miyamoto, M, Unger, MM, Cochen De Cock, V, Wolfson, C (2012). Environmental risk factors for REM sleep behavior disorder - A multicentre case-control study. Neurology, 79(5):428-34.

20) Arnulf, I., Bin, Z., Uguccioni, G., Flamand, M., Noël de Fontréaulx, A., Leu-Semenescu, S., et al. (2013). A scale for assessing the severity of arousal disorders. Sleep, sous presse.

21) Dauvilliers, Y., Postuma, R., Ferini Strambi, L., Arnulf, I., Högl, B., Manni, R., et al. (2013). Family history of idiopathic REM behavior disorder – A multicentre case-control study. Neurology. Sous presse.

22) Faraco, J., Lin, L., Kornum, B. R., Kenny, E. E., Trynka, G., Einen, M., Rico, T. J., Lichtner, P., Dauvilliers, Y., Arnulf, I., et al. (2013). ImmunoChip study implicates antigen presentation to T cells in narcolepsy. PLoS Genet, 9(2), e1003270.

23) Nittur, N., Konofal, E., Dauvilliers, Y., Franco, P., Leu-Semenescu, S., Cock, V. C., Inocente, C. O., Bayard, S., Scholtz, S., Lecendreux, M., Arnulf, I. (2013). Mazindol in narcolepsy and idiopathic and symptomatic hypersomnia refractory to stimulants: a long-term chart review. Sleep Med, 14(1), 30-36.

24) Uguccioni, G., Golmard, J. L., de Fontreaulx, A. N., Leu-Semenescu, S., Brion, A., Arnulf, I. (2013). Fight or flight? Dream content during sleepwalking/sleep terrors vs rapid eye movement sleep behavior disorder. Sleep Med, 14(5), 391-398.

25) Leu-Semenescu, S, UguccioniG, Golmard JL, Czernecki V, Yelnik J, Dubois B, Forgeot d’Arc B, Levy R, Arnulf, I. Can we still dream when the mind is blank? Sleep and dream mentations in auto-activation déficits. Brain 2013, sous presse.

26) Dauvilliers Y, Arnulf I, Lecendreux M, Monaca C, Franco P, Tubert-Bitter P, d'Ortho MP, Launois S, Lignot S, Weibel D, Boehenoffer J, Sturkenboom M, Bourgin P, Nogues B, Drouot X, Rey M, Bayard S, Scholz S, Lavault S, Saussier C, Pariente A. Increased incidence of narcolepsy-cataplexy in adults and children after H1N1 influenza vaccination in France. Brain 2013, sous presse.

Current/Completed Grants (past 5 years) PHRC NARCOBANK 2007-2011
KLS Foundation grant
NRJ-Institute of France grant
APHP grant

Other laboratory Members
Title MD First Name Smaranda Last Name Leu-Semenescu Position Senior neurologist E-Mail  
Title MSc First Name Ginevra Last Name Uguccioni Position psychologist E-Mail  
Title MSc First Name Sophie Last Name Lavault Position PhD student, research assistant E-Mail  
Title PhD,MD First Name Stefania Last Name Redolfi Position senior pneumologist E-Mail  
Title MD First Name Valérie Last Name Attali Position senior pneumologist E-Mail  
Title PhD,MD First Name Carole Last Name Philippe Position seniro physiologist E-Mail  
Title PhD,MD First Name Emmanuel Last Name Mignot Institution Stanford university, CA, USA  
Title PhD,MD First Name Jacques Last Name Montplaisir Institution Quebec University  
Title PhD,MD First Name Ron Last Name Postuma Institution Mc Gill University, CA  
Title PhD First Name Mehdi Last Name Tafti Institution Lausanne University, SW  
Title PhD,MD First Name Yves Last Name Dauvilliers Institution Montellier University, France  
Past Members