European Sleep Research Laboratories

Neuroenergetic and Cellular Dynamic Laboratory - S

CHUV
Center for Psychiatric Neuroscience


Petit Jean-Marie
Route du Mont
1008 Prilly Switzerland


Position Responsable de Recherche Phone + 41 21 3146227 Fax + 41 21 693 18 97 Contact E-Mail jean-marie.petit@Chuv.ch   Research Domain
  • Clinical
  • Basic Animal

Keywords
  • Sleep and Psychiatry-Personality Disorders
  • Sleep Physiology-Neurophysiology in Human
  • Sleep Physiology-Neurophysiology in Animal
  • Biological Rhythms
  • Molecular Biology-Endocrinology-Biochemistry

Laboratory Description We fovcused our investigations on the role of astrocytes in sleep regulation throughout their involvement in energy metabolism.
We mainly used models of sleep deprivation/ fragmentation in mice.
We also used biosensors for brain metabolites measurements.

Technical Capabilities and areas of expertise polygraphic sleep recording in rodent (mice), Locomotor and body temperature rhythms by telemetry, in vivo biosensors, microdialysis, qPCR,
Additional Descriptors, Keywords Energy metabolism,
Selected Publications in the 5 past years - The psychostimulant modafinil enhances gap junctional communication in cortical astrocytes. Petit, J-M; Liu, X; Gyger, J; Magistretti, P.J; Giaume, C. Neuropharmacology (2013); ahead of print 05/2013; DOI:10.1016/j.
- Genes Involved in the Astrocyte-Neuron Lactate Shuttle (ANLS) Are Specifically Regulated in Cortical Astrocytes Following Sleep Deprivation in Mice. Petit J-M; Gyger J; Burlet-Godinot S; Fiumelli H; Martin J-L; Magistretti PJ. Sleep (2013); 36(10):1445-1458.
- Sustained sleep fragmentation affects brain temperature, food intake and glucose tolerance in mice. Baud MO; Magistretti PJ; Petit J-M. J. Sleep Res. (2013); 22(1):3-12.
- Metabolic response of the cerebral cortex following gentle sleep deprivation and modafinil administration. Petit, J-M; Tobler, I: Kopp C; Morgenthaler F; Borbély AA; Magistretti PJ. Sleep. (2010); 33(7):901-8.
- Astrocytes and sleep homeostasis. Magistretti PJ; Petit J-M. Front in Neurosci (2009); 3(3):415.

 
Other laboratory Members
 
First Name Sophie Last Name Burlet-Godinot E-Mail Sophie.Burlet@chuv.ch  
Collaborations
 
 
Past Members
 
Title PhD,MD First Name Maxime Last Name Baud Position PhD student E-Mail Maxime.Baud@ucsf.edu  
Title MSc First Name Anna Last Name Mikhaleva Position MSc student E-Mail anna.mikhaleva@epfl.ch