European Sleep Research Laboratories

Sleep & Epilepsy Center, Neurocenter of Southern S

Civic Hospital (EOC) of Lugano


Mauro Manconi
Via Tesserete 46
6903 Lugano Switzerland


Position Head of service Phone +41 91 811 6825 Fax +41 91 811 6915 Contact E-Mail mauro.manconi@eoc.ch   Research Domain
  • Clinical
  • Basic Human

Keywords
  • Instrumentation-Methodology
  • Sleep and Medical Disorders
  • Biological Rhythms
  • Paediatric Sleep Disorders
  • Behavioural Sleep Disorders
  • Neurological Sleep Disorders

Laboratory Description The clinical sleep lab is a multidisciplinary sleep center. The main clinical research topics are sleep-related movement disorders, parasomnias and insomnia.
Technical Capabilities and areas of expertise Video-polysomnography, multiple sleep latency test, maintenance of wakefulness test, vigilance testing, driving simulator, polygraphy, actigraphy, high-density EEG, salivary melatonin profiling, cognitive behavioral therapy, light therapy
Additional Descriptors, Keywords Sleep-related movement disorders, parasomnias, insomnia, circadian disorders, cognitive behavioral therapy, light therapy
Selected Publications in the 5 past years 1. Manconi M, Ferri R, Zucconi M, Bassetti CL, Fulda S, Aricò D, Ferini-Strambi L. Dissociation of periodic leg movements from arousals in restless legs syndrome. Ann Neurol. 2012 Jun;71(6):834-44.

2. Manconi M, Ulfberg J, Berger K, Ghorayeb I, Wesström J, Fulda S, Allen RP, Pollmächer T. When gender matters: restless legs syndrome. Report of the "RLS and woman" workshop endorsed by the European RLS Study Group. Sleep Med Rev. 2012 Aug;16(4):297-307.

3. Fulda S, Kloiber S, Dose T, Lucae S, Holsboer F, Schaaf L, Hennings J (2013) Mirtazapine provokes periodic leg movements during sleep in young healthy men. Sleep; 36(5): 661-669

4. Manconi M, Ferri R, Zucconi M, Clemens S, Giarolli L, Bottasini V, Ferini-Strambi L. Preferential D2 or preferential D3 dopamine agonists in restless legs syndrome. Neurology. 2011 Jul 12;77(2):110-7

5. Manconi M, Ferri R, Zucconi M, Oldani A, Giarolli L, Bottasini V, Ferini-Strambi L. Pramipexole versus ropinirole: polysomnographic acute effects in restless legs syndrome. Mov Disord. 2011 Apr;26(5):892-5.

6. Fulda S, Romanowski CPN, Becker A, Wetter TC, Kimura M, Fenzl T (2011) Rapid eye movements during sleep in mice: High trait-like stability qualifies rapid eye movement density for characterization of phenotypic variation in sleep patterns of rodents. BMC Neuroscience 12:110 doi: 10.1186/1471-2202-12-110.

7. Fulda S, Szesny N, Ising M, Heck A, Grübl A, Lieb R, Reppermund S (2011) Further evidence for executive dysfunction in subjects with RLS from a non-clinical sample. Sleep Medicine; 10: 1003-1007.

8. Cesnik E, Casetta I, Turri M, Govoni V, Granieri E, Strambi LF, Manconi M. Transient RLS during pregnancy is a risk factor for the chronic idiopathic form. Neurology. 2010 Dec 7;75(23):2117-20.

9. Manconi M, Ferri R, Sagrada C, Punjabi NM, Tettamanzi E, Zucconi M, Oldani A, Castronovo V, Ferini-Strambi L. Measuring the error in sleep estimation in normal subjects and in patients with insomnia. J Sleep Res. 2010 Sep;19(3):478-86.

10. Fulda S, Beitinger ME, Reppermund S, Winkelmann J, Wetter TC (2010) Short-term attention and verbal fluency is decreased in restless legs syndrome patients. Movement Disorders; 25: 2641-2648.

11. Manconi M, Ferri R, Zucconi M, Clemens S, Rundo F, Oldani A, Ferini-Strambi L. Effects of acute dopamine-agonist treatment in restless legs syndrome on heart rate variability during sleep. Sleep Med. 2011 Jan;12(1):47-55.

12. Manconi M, Ferri R, Feroah TR, Zucconi M, Ferini-Strambi L. Defining the boundaries of the response of sleep leg movements to a single dose of dopamine agonist. Sleep. 2008 Sep;31(9):1229-37.

13. Italian REMS Study Group, Manconi M, Ferini-Strambi L, Filippi M, Bonanni E, Iudice A, Murri L, Gigli GL, Fratticci L, Merlino G, Terzano G, Granella F, Parrino L, Silvestri R, Aricò I, Dattola V, Russo G, Luongo C, Cicolin A, Tribolo A, Cavalla P, Savarese M, Trojano M, Ottaviano S, Cirignotta F, Simioni V, Salvi F, Mondino F, Perla F, Chinaglia G, Zuliani C, Cesnik E, Granieri E, Placidi F, Palmieri MG, Manni R, Terzaghi M, Bergamaschi R, Rocchi R, Ulivelli M, Bartalini S, Ferri R, Lo Fermo S, Ubiali E, Viscardi M, Rottoli M, Nobili L, Protti A, Ferrillo F, Allena M, Mancardi G, Guarnieri B, Londrillo F. Multicenter case-control study on restless legs syndrome in multiple sclerosis: the REMS study. Sleep. 2008 Jul;31(7):944-52.

14. Manconi M, Rocca MA, Ferini-Strambi L, Tortorella P, Agosta F, Comi G, Filippi M. Restless legs syndrome is a common finding in multiple sclerosis and correlates with cervical cord damage. Mult Scler. 2008 Jan;14(1):86-93.

15. Fulda S, Wetter TC (2008) Where dopamine meets opioids: a meta-analysis of the placebo effect in RLS treatment studies. Brain; 131: 902-917.

16. Fulda S, Hornyak M, Müller K, Cerny L, Beitinger PA, Wetter TC (2008) Development and Validation of the Munich Parasomnia Screening (MUPS): A Questionnaire for Parasomnias and Nocturnal Behaviors. Somnology; 12: 56-65

Key Publications of the Laboratory 1. Manconi M, Ferri R, Zucconi M, Bassetti CL, Fulda S, Aricò D, Ferini-Strambi L. Dissociation of periodic leg movements from arousals in restless legs syndrome. Ann Neurol. 2012 Jun;71(6):834-44.

2. Cesnik E, Casetta I, Turri M, Govoni V, Granieri E, Strambi LF, Manconi M. Transient RLS during pregnancy is a risk factor for the chronic idiopathic form. Neurology. 2010 Dec 7;75(23):2117-20.

3. Manconi M, Ferri R, Sagrada C, Punjabi NM, Tettamanzi E, Zucconi M, Oldani A, Castronovo V, Ferini-Strambi L. Measuring the error in sleep estimation in normal subjects and in patients with insomnia. J Sleep Res. 2010 Sep;19(3):478-86.

4. Fulda S, Beitinger ME, Reppermund S, Winkelmann J, Wetter TC (2010) Short-term attention and verbal fluency is decreased in restless legs syndrome patients. Movement Disorders; 25: 2641-2648.

5. Manconi M, Ferri R, Feroah TR, Zucconi M, Ferini-Strambi L. Defining the boundaries of the response of sleep leg movements to a single dose of dopamine agonist. Sleep. 2008 Sep;31(9):1229-37.

6. Fulda S, Wetter TC (2008) Where dopamine meets opioids: a meta-analysis of the placebo effect in RLS treatment studies. Brain; 131: 902-917.

7. Italian REMS Study Group, Manconi M, Ferini-Strambi L, Filippi M, Bonanni E, Iudice A, Murri L, Gigli GL, Fratticci L, Merlino G, Terzano G, Granella F, Parrino L, Silvestri R, Aricò I, Dattola V, Russo G, Luongo C, Cicolin A, Tribolo A, Cavalla P, Savarese M, Trojano M, Ottaviano S, Cirignotta F, Simioni V, Salvi F, Mondino F, Perla F, Chinaglia G, Zuliani C, Cesnik E, Granieri E, Placidi F, Palmieri MG, Manni R, Terzaghi M, Bergamaschi R, Rocchi R, Ulivelli M, Bartalini S, Ferri R, Lo Fermo S, Ubiali E, Viscardi M, Rottoli M, Nobili L, Protti A, Ferrillo F, Allena M, Mancardi G, Guarnieri B, Londrillo F. Multicenter case-control study on restless legs syndrome in multiple sclerosis: the REMS study. Sleep. 2008 Jul;31(7):944-52.

8. Winkelmann J, Schormair B, Lichtner P, Ripke S, Xiong L, Jalilzadeh S, Fulda S, Pütz B, Eckstein G, Hauk S, Trenkwalder C, Zimprich A, Stiasny-Kolster K, Oertel W, Bachmann CG, Paulus W, Peglau I, Eisensehr I, Montplaisir J, Turecki G, Rouleau G, Gieger C, Illig T, Wichmann HE, Holsboer F, Müller-Myhsok, B, Meitinger T (2007) Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions. Nature Genetics; 39: 1000-1006.

9. Ferri R, Zucconi M, Manconi M, Plazzi G, Bruni O, Ferini-Strambi L. New approaches to the study of periodic leg movements during sleep in restless legs syndrome. Sleep. 2006 Jun;29(6):759-69.

10. Zucconi M, Ferri R, Allen R, Baier PC, Bruni O, Chokroverty S, Ferini-Strambi L, Fulda S, Garcia-Borreguero D, Hening WA, Hirshkowitz M, Högl B, King M, Montagna P, Parrino L, Plazzi G, Terzano MG. (2006) The official World Association of Sleep Medicine (WASM) standards for recording and scoring periodic leg movements in sleep (PLMS) and wakefulness (PLMW) developed in collaboration with a task force from the International Restless Legs Syndrome Study Group (IRLSSG). Sleep Medicine; 7(2): 175-183.

11. Manconi M, Govoni V, De Vito A, Economou NT, Cesnik E, Casetta I, Mollica G, Ferini-Strambi L, Granieri E. Restless legs syndrome and pregnancy. Neurology. 2004 Sep 28;63(6):1065-9.

12. Schneider C, Fulda S, Schulz H. (2004) Daytime variation in performance and tiredness/sleepiness ratings in patients with insomnia, narcolepsy, sleep apnea and normal controls. Journal of Sleep Research; 13: 373-83.

13. Fulda S, Schulz H (2001) Cognitive dysfunction in sleep disorders. Sleep Medicine Reviews, 5; 423-445.

14. Fulda S, Schulz H (2003) Cognitive dysfunction in sleep-related breathing disorders: a meta-analysis. Sleep Research Online; 5:13-43.

Current/Completed Grants (past 5 years) 2013 - 2015: Swiss National Science Foundation, Autonomic function and cardiovascular risk in restless legs syndrome

 
Other laboratory Members
 
Title PhD First Name Stephany Last Name Fulda Position Researcher, Clinician E-Mail stephany.fulda@gmail.com  
Collaborations
 
 
Past Members