European Sleep Research Laboratories

Sleep, Cognition and Health"

Karolinska Institute
Clinical Neuroscience

PhD
John Axelsson
Nobels väg 9
17177 Stockholm Sweden


Position Associate Professor Phone +46 8 52482461 Fax +46 8 52482461 Contact E-Mail john.axelsson@ki.se Website http://ki.se/en/cns/john-axelssons-research-group   Research Domain
  • Basic Human

Keywords
  • Sleep and Body Functions (Cardio-Respiratory, Thermoregulation/Metabolism, Endocrine)
  • Learning, Memory, Cognition

Laboratory Description With our research we aim to increase the knowledge and awareness of how sleep in the modern life affects our biology, cognition and health. A main focus is to investigate how disturbed sleep affects us both acutely and chronically with respect to immune function, metabolism and subjective health. Another research area includes how disturbed sleep affects cognitive processes and how we interact with our peers. We are also pursuing research in how sickness and disease affects cognition and behaviour.

Our research is strongly interdisciplinary which is also reflected by our methodology, with methods ranging from the photographing of sleep deprived individuals to injections with (dead) bacteria to investigate brain activity with brain imaging techniques when someone is acutely sick.

Technical Capabilities and areas of expertise Experimental sleep deprivation and quasi experimental set-ups (mainly in shift workers and paitent groups). Human experimental sickness models (injections with lipopolysaccharide, LPS).
Selected Publications in the 5 past years Selected publications: Sleep, immune function and health
Lasselin J, Rehman J, Åkerstedt T, Lekander M, Axelsson J. Effect of long-term sleep restriction and subsequent recovery sleep on the diurnal rhythms of white blood cell subpopulations, Brain Behavior and Immunity (in press)

Axelsson J, Rehman J, Akerstedt T, Ekman R, Miller GE, Olgart-Hoglund C & Lekander M. Effects of sustained sleep restriction on mitogen-stimulated cytokines, chemokines and T helper 1/ T helper 2 balance in humans PLoS One. 2013 Dec 11;8(12):e82291. doi: 10.1371/journal.pone.0082291. [PMID: 24349251]

Lekander M, Andreasson AN, Kecklund G, Ekman R, Ingre M, Akerstedt T, Axelsson J. Subjective health perception in healthy young men changes in response to experimentally restricted sleep and subsequent recovery sleep. Brain Behavior and Immunity. 2013 Jun 29. doi:pii: S0889-1591(13)00229-8. 10.1016/j.bbi.2013.06.005. [PMID: 23820239]

Jernelöv S. Lekander M. Blom K. Rydh S. Ljótsson B., Axelsson J. & Kaldo V. Efficacy of a Behavioral Self-help Treatment With or Without Therapist Guidance for Insomnia With Co-morbid Problems – a Randomized Controlled Trial. BMC Psychiatry, 2012 Jan 22;12:5. doi: 10.1186/1471-244X-12-5. [PMID: 22264332]

Fondell E. Axelsson J. Franck K. Ploner A. Lekander M. Balter K & Gaines H. Short Natural Sleep is Associated with Higher T Cell and Lower NK Cell Activities Brain, Behavior, and Immunity, 2011 Oct;25(7):1367-75, [PMID: 21496482]

Rehman JU. Brismar K. Holmbäck U. Akerstedt T & Axelsson J. Sleeping during the day: effects on the 24-h patterns of insulin-like growth factor binding protein-1 (IGFBP-1), insulin, glucose, cortisol and growth hormone (GH). Eur J Endocrinol. 2010 Sep;163(3):383-90. Jun 29. [PMID: 20587581]


Selected publications: Sleep and social cognition
Sundelin T, Lekander M, Kecklund G, van Someren E, Olsson A & Axelsson J. Cues of fatigue: Effects of sleep deprivation on facial appearance. Sleep. 2013 Sep 1;36(9):1355-60. doi: 10.5665/sleep.2964. [PMID: 23997369]

Axelsson J. Sundelin T. Ingre M. Olsson A. van Someren E & Lekander M. Beauty Sleep: Experimental study on the perceived health and attractiveness of sleep deprived people BMJ, 2010 Dec 15. 341:c6614, [PMID: 21156746]


Selected publications: Sickness behaviour
Karshikoff B. Lekander M. Soop A. Lindstedt F. Ingvar M, Kosek E. Hoglund CO. Axelsson J. Modality and sex differences in pain sensitivity during human endotoxemia. Brain Behavior and Immunity (accepted)

Olsson M, Lundstrom J, Gordon A, Karshikoff B, Hosseini N, Sorjonen K, Olgart C, Soop A, Axelsson J, Lekander M. The scent of disease: Human body odor contains an early chemosensory cue of sickness, Psychological Science, 2014 Jan 22, 25(3): 817-23 [PMID 24452606]

Key Publications of the Laboratory Axelsson J. Sundelin T. Ingre M. Olsson A. van Someren E & Lekander M. Beauty Sleep: Experimental study on the perceived health and attractiveness of sleep deprived people BMJ, 2010 Dec 15. 341:c6614, [PMID: 21156746]

Nilsson J, Söderström M, Karlsson A, Lekander M, Åkerstedt T, Erixon Lindroth N. & Axelsson J. Less effective executive functioning after one night's sleep deprivation. J. of Sleep Research. 2005 Mar;14(1):1-6. [PMID: 15743327]

Axelsson J, Ingre M, Åkerstedt T. & Holmbäck U. Effects of displaced sleep on testosterone. J. Clin. Endocrinol. Metab. 2005 Aug;90(8):4530-5. [PMID: 15914523]

Lekander M, Andreasson AN, Kecklund G, Ekman R, Ingre M, Akerstedt T, Axelsson J. Subjective health perception in healthy young men changes in response to experimentally restricted sleep and subsequent recovery sleep. Brain Behavior and Immunity. 2013 Jun 29. doi:pii: S0889-1591(13)00229-8. 10.1016/j.bbi.2013.06.005. [PMID: 23820239]

Karshikoff B. Lekander M. Soop A. Lindstedt F. Ingvar M, Kosek E. Hoglund CO. Axelsson J. Modality and sex differences in pain sensitivity during human endotoxemia. Brain Behavior and Immunity (accepted)

Current/Completed Grants (past 5 years) Present research funding
Karolinska Institute PhD-funding, 1 040 000 kr, 2014-2017 (PI)
Swedish Tercentary fund (RJ), 1 568 000 kr, 2014-2015 (PI)
Swedish research council (VR-HS), 2 340 000 kr, 2014-2016 (PI)
SRPDiabetes, 1 000 000 kr, 2012-2014 (PI)
Swedish research council (VR-HS), 5 057 000 kr, 2014-2017 (Co-PI)
FORTE, 1 980 000 kr, 2014-2015 (Co-PI)
FORTE (Center grant), 50 000 000 kr (Co-PI)

 
Other laboratory Members
 
Title MSc First Name Bianka Last Name Karshikoff Position PhD-student E-Mail bianka.karshikoff@ki.se  
Title MSc First Name Tina Last Name Sundelin Position PhD-student E-Mail Tina.Sundelin@ki.se  
First Name Julie Last Name Lasselin Position Postdoc E-Mail julie.lasselin@ki.se  
Title MSc First Name Lukasz Last Name Cybulski Position Research assistant E-Mail lukasz.cybulski@ki.se  
Title MSc First Name Malin Last Name Eriksson Position Research assistant E-Mail mailin.eriksson1@ki.se  
Collaborations
 
Title PhD First Name Mats Last Name Lekander  
First Name Göran Last Name Kecklund  
First Name Predrag Last Name Petrovic  
Past Members