European Sleep Research Laboratories

University of Oxford Sleep Research Centre

Current Announcements Our online MSc/ PgDip in Sleep Medicine will be launched in 2015.
Enquiries to Dr Chris Harvey (christopher-james.harvey@ndcn.ox.ac.uk)

University of Oxford
Nuffield Department of Clinical Neurosciences


Colin A Espie
John Radcliffe Hospital
OX3 9DU Oxford United Kingdom


Position Professor of Sleep Medicine Phone +44 (0)7809 111626 Fax - Contact E-Mail colin.espie@ndcn.ox.ac.uk   Research Domain
  • Clinical
  • Basic Human
  • Basic Animal

Keywords
  • Biological Rhythms
  • Behavioural Sleep Disorders
  • Sleep Physiology-Neurophysiology in Animal
  • Others

Laboratory Description Human: Clinical and behavioural assessment of sleep disorders, actigraphy, ambulatory PSG, online evaluations.

Animal: Equipment for in vivo electrophysiology, automated touchscreen set up for rodent behaviour, equipment for optogenetics, animal models of disease (at the Sleep, Brain and Behaviour Lab, http://vvlab.org)

Technical Capabilities and areas of expertise Human: Insomnia, circadian disorders: clinical and behavioural assessment, neuropsychological appraisal, cognitive and performance testing, actigraphy, neurophysiology, PSG, PSA, online evaluations

Animal: Recording and analysis of sleep in rodents, chronic recordings of cortical/subcortical neuronal activity in freely-moving rodents, signal analysis (at the Sleep, Brain and Behaviour Lab, http://vvlab.org)

Selected Publications in the 5 past years www.ndcn.ox.ac.uk/colin-espie
http://www.psych.ox.ac.uk/team/PIs/daniel-freeman
http://www.eye.ox.ac.uk/team/principal-investigators/katharina-wulff
http://www.ndcn.ox.ac.uk/team/support-staff/christopher-james-harvey;d=TkxP

1. Espie, C.A., Inglis, S.J., Tessier, S., and Harvey, L. (2001) The clinical effectiveness of cognitive behaviour therapy for chronic insomnia: Implementation and evaluation of a Sleep Clinic in general medical practice. Behaviour Research and Therapy 39, 45-60

2. Espie, C.A. (2002) Insomnia: Conceptual issues in the development, persistence and treatment of sleep disorder in adults. Annual Review of Psychology 53, 215-243

3. Espie, C.A., Broomfield, N.M., MacMahon K.M.A., Macphee, L.M. & Taylor, L.M. (2006) The attention-intention-effort pathway in the development of Psychophysiologic Insomnia: a theoretical review. Sleep Medicine Reviews 10, 215-245

4. Espie, C.A., MacMahon, K.M.A., Kelly, H-L., Broomfield, N.M., Douglas, N.J., Engleman, H.E., McKinstry, B., Morin, C.M. Walker, A. & Wilson, P. (2007) Randomised clinical effectiveness trial of nurse-administered small group CBT for persistent insomnia in general practice. Sleep 30, 574-584

5. Espie, C.A., Fleming, L., Cassidy, J., Samuel, L., Taylor, L.M., White, C.A., Douglas, N.J., Engleman, H.E., Kelly, H-L. & Paul, J. (2008) Randomized controlled clinical effectiveness trial of Cognitive Behavior Therapy versus Treatment as Usual for persistent insomnia in cancer patients. Journal of Clinical Oncology 26, 4651-4658

6. Espie, C.A., Kyle, S.D, Williams, C., Ong, J.C., Douglas, N.J., Hames, P., Brown, J.S.L. (2012) A randomized, placebo-controlled, trial of online Cognitive Behavioral Therapy for chronic Insomnia Disorder delivered via an automated media-rich web application. SLEEP, Vol. 35, No. 6, 769-781

7. Vyazovskiy VV, Cui N, Rodriguez AV, Funk C, Cirelli C, et al. (2014) The dynamics of cortical neuronal activity in the first minutes after spontaneous awakening in rats and mice. Sleep 37: 1337-1347.

8. Vyazovskiy VV, Harris KD (2013) Sleep and the single neuron: the role of global slow oscillations in individual cell rest. Nat Rev Neurosci 14: 443-451.

9. Vyazovskiy VV, Olcese U, Hanlon EC, Nir Y, Cirelli C, et al. (2011) Local sleep in awake rats. Nature 472: 443-447.

10. Nir Y, Staba RJ, Andrillon T, Vyazovskiy VV, Cirelli C, et al. (2011) Regional slow waves and spindles in human sleep. Neuron 70: 153-169.

11. Leemburg S, Vyazovskiy VV, Olcese U, Bassetti CL, Tononi G, et al. (2010) Sleep homeostasis in the rat is preserved during chronic sleep restriction. Proc Natl Acad Sci U S A 107: 15939-15944.

12. Freeman, D. & Garety, P. (2014). Advances in understanding and treating persecutory delusions. Social Psychiatry and Psychiatric Epidemiology, 49, 1179-1189.

13. Freeman, D., Startup, H., Myers, E., Harvey, A., Geddes, J., Yu, L-M., Zaiwalla, Z., Luengo-Fernandez, R., Foster, R., & Lister, R. (2013). The effects of using cognitive behavioural therapy to improve sleep for patients with delusions and hallucinations (the BEST study): study protocol. Trials, 14, 214.

14. Freeman, D., Stahl, D., McManus, S., Meltzer, H., Brugha, T., Wiles, N., & Bebbington, P. (2012). Insomnia, worry, anxiety and depression as predictors of the occurrence and persistence of paranoid thinking. Social Psychiatry and Psychiatric Epidemiology, 47, 1195-1203.

15. Myers, E., Startup, H., & Freeman, D. (2011). Cognitive behavioural treatment of insomnia in individuals with persistent persecutory delusions. Journal of Behavior Therapy and Experimental Psychiatry, 42, 330-336.

16. Freeman, D., Brugha, T., Meltzer, H., Jenkins, R., Stahl, D., & Bebbington, P. (2010). Persecutory ideation and insomnia: findings from the second British National Survey of Psychiatric Morbidity. Journal of Psychiatric Research, 44, 1021-1026.



Key Publications of the Laboratory www.ndcn.ox.ac.uk/colin-espie
http://www.psych.ox.ac.uk/team/PIs/daniel-freeman
http://www.eye.ox.ac.uk/team/principal-investigators/katharina-wulff
http://www.ndcn.ox.ac.uk/team/support-staff/christopher-james-harvey;d=TkxP

1. Espie, C.A., Kyle, S.D, Williams, C., Ong, J.C., Douglas, N.J., Hames, P., Brown, J.S.L. (2012) A randomized, placebo-controlled, trial of online Cognitive Behavioral Therapy for chronic Insomnia Disorder delivered via an automated media-rich web application. SLEEP, Vol. 35, No. 6, 769-781

2. Espie, C.A., Barrie, L.M., Forgan, G.S. (2012) Comparative investigation of the psychophysiological and idiopathic Insomnia Disorder phenotypes: psychological characteristics, patients’ perspectives and implications for clinical management. SLEEP, Vol. 35, No. 3, 385-393

3. Green, M., Benzeval, M., Espie, C.A., Hunt, K. (2012) The longitudinal course of insomnia symptoms: inequalities by gender and occupational class among two different age cohorts followed for 20 years in the West of Scotland. SLEEP 35, 815-823

4. Espie., C.A., Kyle, S.D., Hames, P., Cyhlarova E., Benzeval, M. (2012) The daytime impact of DSM-5 Insomnia Disorder: comparative analysis of insomnia subtypes from the Great British Sleep Survey (n=11,129) Journal of Clinical Psychiatry 73, e1478-e1484

5. Espie, C.A., Kyle, S.D., Hames, P., Gardani, M., Fleming, L., Cape, J. (2014). The Sleep Condition Indicator: a clinical screening tool to evaluate Insomnia Disorder. BMJOpen 4 (3): e004183

6. Vyazovskiy VV, Harris KD (2013) Sleep and the single neuron: the role of global slow oscillations in individual cell rest. Nat Rev Neurosci 14: 443-451.

7. Vyazovskiy VV, Olcese U, Hanlon EC, Nir Y, Cirelli C, et al. (2011) Local sleep in awake rats. Nature 472: 443-447.

8. Leemburg S, Vyazovskiy VV, Olcese U, Bassetti CL, Tononi G, et al. (2010) Sleep homeostasis in the rat is preserved during chronic sleep restriction. Proc Natl Acad Sci U S A 107: 15939-15944.

9. Vyazovskiy VV, Olcese U, Lazimy YM, Faraguna U, Esser SK, et al. (2009) Cortical firing and sleep homeostasis. Neuron 63: 865-878.

10. Vyazovskiy VV, Cirelli C, Pfister-Genskow M, Faraguna U, Tononi G (2008) Molecular and electrophysiological evidence for net synaptic potentiation in wake and depression in sleep. Nature Neurosci 11: 200-208.

11. Freeman, D., Pugh, K., Vorontsova, N. & Southgate, L. (2009). Insomnia and paranoia. Schizophrenia Research, 108, 280-284.

12. Freeman, D., Pugh, K., Antley, A., Slater, M., Bebbington, P., Gittins, M., Dunn, G., Kuipers, E., Fowler, D., & Garety, P. A (2008). A virtual reality study of paranoid thinking in the general population. British Journal of Psychiatry, 192, 258-263.

13. Freeman, D. (2007). Suspicious minds: the psychology of persecutory delusions. Clinical Psychology Review, 27, 425-457.

14. Freeman, D., Garety, P.A., Kuipers, E., Fowler, D., & Bebbington, P.E. (2002). A cognitive model of persecutory delusions. British Journal of Clinical Psychology, 41, 331-347.

15. Garety, P.A. & Freeman, D. (1999). Cognitive approaches to delusions: a critical review of theories and evidence. British Journal of Clinical Psychology, 38, 113-154.



 
Other laboratory Members
 
Title PhD First Name Katharina Last Name Wulff E-Mail katharina.wulff@ndcn.ox.ac.uk  
Title PhD First Name Daniel Last Name Freeman E-Mail daniel.freeman@psych.ox.ac.uk  
Title PhD First Name Russell Last Name Foster E-Mail russell.foster@ndcn.ox.ac.uk  
Title PhD First Name Chris Last Name Harvey E-Mail christopher-james.harvey@ndcn.ox.ac.uk  
Title PhD First Name Vladyslav Last Name Vyazovskiy E-Mail vladyslav.vyazovskiy@dpag.ox.ac.uk  
First Name Bryony Last Name Sheaves E-Mail bryony.sheaves@psych.ox.ac.uk  
First Name Felicity Last Name Waite E-Mail felicity.waite@psych.ox.ac.uk  
Title BSc,MSc,PhD First Name Gari Last Name Clifford E-Mail gari.clifford@gmail.com  
First Name Zenobia Last Name Zaiwalla MRCP, FRCP, FRCPCH E-Mail Zenobia.Zaiwalla@ouh.nhs.uk  
Title PhD First Name Claire Last Name Sexton Position Postdoctoral research assistant and EPA Cephalosporin Junior Research Fellow E-Mail claire.sexton@ndcn.ox.ac.uk  
Collaborations
 
Past Members