European Sleep Research Laboratories

UR2NF - Neuropsychology and Functional Neuroimagin

Université Libre de Bruxelles (ULB)
Faculty of Psychological Sciences


Philippe Peigneux
CP191 Av F Roosevelt
1050 Bruxelles Belgium


Position Professor Phone +32 2 650 4581/2631 Fax +32 2 650 2209 Contact E-Mail philippe.peigneux@ulb.ac.be Website http://dev.ulb.ac.be/ur2nf   Research Domain
  • Basic Human

Keywords
  • Learning, Memory, Cognition
  • Sleep and Medical Disorders
  • Sleep and Ageing
  • Sleep and Body Functions (Cardio-Respiratory, Thermoregulation/Metabolism, Endocrine)
  • Sleep Physiology-Neurophysiology in Human
  • Biological Rhythms
  • Behavioural Sleep Disorders
  • Neurological Sleep Disorders

Laboratory Description Researches conducted at the Neuropsychology and Functional Neuroimaging Research Unit [UR2NF - Unité de Recherches en Neuropsychologie et Neuroimagerie Fonctionnelle] are mainly but not exclusively focused on investigating the relationships between sleep and memory consolidation processes, and in a wider perspective centered on the interrelationships between cognitive processes and vigilance states, including sleep and biological rhythms. A specific focus is made on the processes by which novel representations are created in memory and the processes by which novel information is consolidated in long-term memory. We are also interested in the understanding and investigation of major neuropsychological syndromes.
Technical Capabilities and areas of expertise Neuropsychology, Sleep Deprivation, Polysomnography (PSG), Positon Emission Tomography (PET), functional Magnetic Resonance Imaging (fMRI), Magnetoencephalography (MEG), Near Infrared Spectroscopy (NIRS), eyetracking
Additional Descriptors, Keywords neuroimaging, memory consolidation, cognition
Selected Publications in the 5 past years Please see also the UR2NF webpage for a complete list of articles and full text access

1. Peigneux P., Urbain C. and Schmitz R (to appear) Sleep and the Brain. In : Colin Espie and Charles Morin (Eds.), Oxford Handbook of Sleep and Sleep Disorders. New York : Oxford University Press.
2. Dauvilliers Y, Boudousq V, Lopez R, Gabelle A, Bayard S and Peigneux P (to appear) The supplementary motor area and dream-enacting behavior Sleep Medicine F.I. : 3,699
3. Peigneux P. and Smith C. (2010) Sleep and Memory. In : Meir H Kryger (Ed.), Principles and Practice of Sleep Medicine, 5th Edition. Philadelphia : Elsevier
4. Peigneux P., Schmitz R and Urbain C. (2010) Sleep and Forgetting. In : Sergio Della Sala (Ed.), Current Issues in Memory : Forgetting. London : Psychology Press and Routledge, 352 pp
5. Neu D, Kajosch H, Peigneux P, Verbanck P, Linkowski P, Le Bon O (2010) Cognitive impairment in fatigue and sleepiness associated conditions. Psychiatry Research PMID: 21196050 F.I. : 2,373
6. Schmidt C, Collette F, Leclercq Y, Sterpenich V, Vandewalle G, Berthomier P, Berthomier C, Philipps C, Tinguely G, Darsaud A, Gais S, Schabus M, Desseilles M, DangVu TT, Salmon E, Balteau E, Degueldre C, Luxen A, Maquet P, Cajochen C, and Peigneux P (2009) Homeostatic sleep pressure and responses to sustained attention in the suprachiasmatic area Science 324(5926): 516-519 F.I. : 30,631
7. Schmitz R, Schabus M, Perrin F, Luxen A, Maquet P, and Peigneux P. (2009) Recurrent boosting effects of short inactivity delays on performance: an ERPs study. BMC Res Notes. Aug 26, 2:170. F.I. : N/A
8. Noirhomme Q., Boly M., Bonhomme V., Boveroux P., Phillips C., Peigneux P., Soddu A., Luxen A., Moonen G., Maquet P., Laureys S. (2009) Bispectral index correlates with regional cerebral blood flow during sleep in distinct cortical and subcortical structures in humans. Arch Ital Biol. 147(1-2):51-7.
F.I. : 0,761
9. Rauchs G, Orban P, Schmidt C, Albouy G, Balteau E, Degueldre C, Schnakers C, Sterpenich V, Tinguely G, Luxen A, Maquet P and Peigneux P (2008) Sleep modulates the neural substrates of both spatial and contextual memory consolidation PLoS One3(8): e2949. F.I. : N/A
10. Rauchs G, Orban P, Balteau E, Schmidt C, Degueldre C, Luxen A, Maquet P and Peigneux P (2008) Partially segregated neural networks for spatial and contextual memory in virtual navigation Hippocampus 18(5), 503-518. F.I. : 4,2320
11. Boly M, Philips C, Balteau E, Schnakers C, Degueldre C, Moonen G, Luxen A, Peigneux P, Faymonville M-E, Maquet P, Laureys S (2008) Consciousness and cerebral baseline activity fluctuations Human Brain Mapping 29(7), 868-874. F.I. : 6,1510
12. Albouy G, Sterpenich V, Balteau E, Vandewalle G, Desseilles M, Dang-Vu T, Darsaud A, Ruby P, Luppi P-H, Degueldre C, Peigneux P, Luxen A, Maquet P (2008) Both the Hippocampus and Striatum Are Involved in Consolidation of Motor Sequence Memory. Neuron 58(2), 261-272. F.I. : 13,4100
13. Schnakers, C., Majerus, S., Goldman, S., Boly, M., Van Eeckhout, P., Gay, S., Pellas, F., Bartsch, V., Peigneux, P., Moonen, G., Laureys, S. (2008) Cognitive function in the locked-in syndrome Journal of Neurology 255,323-330. F.I. : 2,8840
14. Schmidt C, Collette C, Cajochen C and Peigneux P (2007) A time to think: circadian rhythms in human cognition [Review] Cognitive Neuropsychology 24(7):755 – 789. F.I. : 2,4300
15. Gais S, Albouy G, Boly M, Dang-Vu TT, Darsaud A, Desseilles M, Rauchs G, Schabus M, Sterpenich V, Vandewalle G, Maquet P and Peigneux P (2007) Sleep transforms the cerebral trace of declarative memories Proc Natl Acad Sci U S A 104(47): 18778-83. F.I. : 9,6430
16. Peigneux P, Schmitz R, and Willems S (2007) Cerebral asymmetries in sleep- dependent processes of memory consolidation Learning and Memory 14:400-406. F.I. : 5,0990
17. Hotermans, C., Peigneux, P., Maertens de Noordhout, A., Moonen, G., Maquet, P. (2006) Early boost and slow consolidation in motor skill learning Learning and Memory, 13(5), 580-583. F.I. : 4,1420
18. Schmidt C., Peigneux P., Muto V., Schenkel M., Knoblauch V., Munch M., De Quervain DJ, Wirz-Justice A., and Cajochen C. (2006). Encoding difficulty promotes postlearning changes in sleep spindle activity during napping. Journal of Neuroscience, 26(35), 8976-8982. F.I. : 7,5060
19. Orban P, Rauchs G, Balteau E, Degueldre C, Luxen A, Maquet P, Peigneux P (2006) Sleep after spatial learning promotes covert reorganization of brain activity PNAS USA 103(8): 7124-7129. F.I. : 10,2310
20. Peigneux P, Orban P, Balteau E, Degueldre C, Luxen A, Laureys S, Maquet P (2006). Offline Persistence of Memory-Related Cerebral Activity during Active Wakefulness. PLoS Biology 4(4): e100. F.I. : 14,6720
21. Vandewalle, G., Balteau, E., Phillips, C., Degueldre, C., Moreau, V., Sterpenich, V., Albouy, G., Darsaud, A., Desseilles, M., Dang-Vu, T., Peigneux, P., Luxen, A., Dijk, D.J. , Maquet, P. (2006) Daytime light dynamically enhances brain responses Current Biology 16(16), 1616-1621. . F.I. : 11,7320
22. Desseilles, M., Dang Vu T.T., Laureys, S., Peigneux, P., Degueldre, C., Phillips, C., Maquet, P. (2006) A prominent role for amygdaloid complexes in the Variability in Heart Rate (VHR) during Rapid-Eye-Movement (REM) sleep, relative to wakefulness. NeuroImage 32(3): 1008-15. F.I. : 5,2880
23. Albouy, G., Ruby, P., Phillips, C., Luxen, A., Peigneux, P., Maquet, P. (2006) Implicit oculomotor sequence learning in humans: Time course of offline processing. Brain Research, 1090(1), 163-171. F.I. : 2,2960
24. Dang-Vu, TT, Desseilles, M, Peigneux, P, and Maquet, P (2006) A role for sleep in brain plasticity Pediatric Rehabilitation 9(2), 98-118. F.I. : N/A

Key Publications of the Laboratory Please see the UR2NF webpage for a complete list of articles and full text access


Current/Completed Grants (past 5 years) 1/10/2010 – 30/09/2015 Action de Recherche Concertée [ARC] project (co-principal promotor) Pathophysiology of brain plasticity processes in memory consolidation. Other promotors P. Van Bogeart (LCFC [Laboratoire de Cartographie Fonctionnelle du Cerveau] et Département de Neurologie Pédiatrique, ULB), A. Kerchove d'Exaerde (Laboratoire de Neurophysiologie, Faculté de Médecine, ULB)
1/10/2010 – 30/09/2013 Brains Back to Brussels project (P. Peigneux promotor) awarded to Dr Rachel Leproult, formerly at Chicago University: A neurophysiological, cognitive and biological investigation of the effects of bedtime extension as an intervention to counteract the adverse effects of chronic sleep loss.
1/1/2009 - 31/12/2012 Crédit aux Chercheurs 1.5.184.10.F (principal promotor): Consolidation or protection against interference? An investigation of the contribution of sleep stages for post-learning memory consolidation processes in narcolepsy and hypersomnia, and in selective naps in healthy subjects
1/1/2010 - 31/12/2012 FRSM project 3.4.508.10.F (co-promotor): Neurophysiology of epileptic interictal activities and of their impact on cognition, language, and sleep-dependent memory process. A MEG, fMRI and FDG-PET multimodal approach. Other promotors Prof P Van Boagert (principal promotor, ULB)
1/1/2010 - 31/12/2010 FRSM project 3.4.516.08.F (co-promotor): Major depressive disorder, emotional bias and working memory: neuroimaging and molecular genetic investigation. Other promotors Dr I Massat (principal promotor, ULB), Prof M Ansseau (ULg), Prof P Verbanck (ULB), Prof J Mendlewicz (ULB)

1/1/2009 - 31/12/2012 FRSM project 3.4.582.09.F (principal promotor): Neural bases of learning and long term consolidation of sequential regularities. Combined effects of discrete vs. continuous learning mode and post-training sleep. Other promotors Dr P Maquet (ULg), Prof A Cleeremans (ULB), Prof P Van Boagert (ULB)
Combined by FNRS request with:
1/1/2009 - 31/12/2012 FRFC project 2.4.627.09.F (co- promotor): The structuration of information in memory: A behavioural and imaging approach of the temporal course of learning. Other promotor Prof A Cleeremans (principal promotor, ULB)

1/1/2008 - 31/12/2011 FRSM project 3.4.594.08.F (principal promotor): The influence of hemispheric lateralization on the dynamics of sleep-dependent memory consolidation processes: a cognitive, neuropsychological and functional brain imaging approach. Other promotors Prof S Goldman (ULB), Prof D Baleriaux (ULB)
1/1/2008 - 31/12/2011 IISN project 4.4.508.08.F (co-promotor): Multi-disciplinary study of residual cerebral activation in altered states of consciousness : EEG-fMRI, MEG and dopaminergic PET analyses of perfusion, electrical and neurotransmission evoked neuronal responses. Other promotors Prof S Goldman (principal promotor, ULB), Prof S Laureys (ULg), Prof A Luxen (ULg)
1/1/2008 - 31/12/2011 FRSM project 3.4.516.08.F (co-promotor): Genetics and ADHD: complementary approaches of case-control association studies and trios with exploration of the relationship between genotype-intermediate phenotype and imaging. Other promotors Dr I Massat (principal promotor, ULB), Prof J Mendlewicz (ULB)
1/1/2008 - 31/12/2010 FRFC project 2.4.621.07.F (co-promotor): Hearing lips and hands : neuroanatomical investigation of phonological processes in deaf adults. Other promotors Prof J Leybaert (principal promotor, ULB), Prof B Charlier (ULB)

 
Other laboratory Members
 
Title MA First Name Remy Last Name Schmitz Position PhD student Psychology E-Mail rschmitz@ulb.ac.be  
Title MA First Name Charline Last Name Urbain Position PhD student Psychology E-Mail curbain@ulb.ac.be  
Title PhD First Name Rachel Last Name Leproult Position Post-doctoral researcher E-Mail rleproul@ulb.ac.be  
Title MA First Name Gaetane Last Name Deliens Position PhD student Psychology E-Mail Gaetane.Deliens@ulb.ac.be  
Title MA First Name Sophie Last Name Galer Position PhD student Psychology E-Mail Sophie.Galer@ulb.ac.be  
Title MA First Name Alison Last Name Mary Position PhD student Psychology E-Mail alismary@ulb.ac.be  
Title MA First Name Hichem Last Name Slama Position PhD student Psychology E-Mail hichem.slama@ulb.ac.be  
Title PhD,MD First Name Isabelle Last Name Massat Position Scientific Collaborator E-Mail imassat@ulb.ac.be  
Title MA First Name Marc Last Name Da Ros Position Scientific Collaborator E-Mail mdaros@ulb.ac.be  
Collaborations
 
Title PhD First Name Christina Last Name Schmidt Position Post-doctoral researcher Institution Universitäre Psychiatrische Kliniken, Abteilung Chronobiologie  
Title PhD First Name Géraldine Last Name Rauchs Position Research Associate Institution Inserm - EPHE - Université de Caen Basse Normandie, Unité de Recherche U923  
Past Members
 
Title PhD First Name Mario Last Name Aparicio de la Concepcion Position Post-doctoral researcher