European Sleep Research Laboratories

Sleep & Cognition

Netherlands Institute for Neuroscience
Sleep & Cognition

Eus JW Van Someren
Meibergdreef 47
1105 BA Amsterdam Netherlands

Position Prof., Head of department Phone +31 20 566 5500 Fax +31 20 566 6121 Contact E-Mail Website   Research Domain
  • Methodology / Technology
  • Clinical
  • Basic Human

  • Instrumentation-Methodology
  • Learning, Memory, Cognition
  • Sleep and Ageing
  • Epidemiology of Sleep
  • Sleep and Body Functions (Cardio-Respiratory, Thermoregulation/Metabolism, Endocrine)
  • Sleep Physiology-Neurophysiology in Human
  • Light and Non-Classical Photoreception
  • Biological Rhythms
  • Neurological Sleep Disorders

Laboratory Description Against the background of their 24-hour rhythm, driven by the circadian clock of the brain, sleep and wakefulness show a mutual dependency. The Sleep & Cognition group investigates how sleep affects brain function during subsequent wakefulness, and how experiences during wakefulness affect subsequent sleep. We aim firstly to elucidate factors that promote and disturb sleep at the systems level, notably insomnia, and secondly to investigate the brain mechanisms involved in the favorable and disruptive effects on cognition of, respectively, sleep and sleep disturbances. We think it’s important to translate fundamental insights into applications to improve sleep, vigilance and daytime function.
Human research tools include, in addition to the standard sleep-lab, brain imaging (high-density-EEG, MEG, fMRI on 1.5, 3 and soon 7 Tesla), transcranial magnetic stimulation (TMS), eye-tracking, computerized induction and assessment of task performance. The sleep-lab has a unique setup for comfortable skin temperature clamping in humans. An arsenal of ambulatory monitoring equipment is available. A web-based assessment tool for extensive insomnia and good sleep phenotyping has resulted in a growing database of, at present, 7000 people. The tool is available for other researchers that want to cooperate.

Technical Capabilities and areas of expertise Assessment: High-density sleep EEG, MRI, TMS, web-based survey and performance phenotyping, ambulatory monitoring.
Manipulation: light, temperature, cognitive behavioral therapy for insomnia, posture, physical activity, stress.

Selected Publications in the 5 past years Lieverse R., Van Someren E.J.W., Nielen M.M., Uitdehaag B., Smit J.H. and Hoogendijk W.J. (2011) Bright light treatment improves mood, sleep and circadian rhythms in elderly patients with major depressive disorder. A Randomized Controlled Trial. Arch Gen Psychiatry 68:61-70.
Axelsson J., Sundelin T., Ingre M., Van Someren E.J.W., Olsson A. and Lekander M. (2010) Beauty sleep: Sleep deprivation affects judged health and attractiveness. Brit Med J 341:c6614.
Van Someren E.J.W. (2010) Doing with less sleep remains a dream. PNAS 107:16003-4.
Altena E, Vrenken H, Van Der Werf YD, Van Den Heuvel OAV and Van Someren EJW (2010) Reduced orbitofrontal and parietal grey matter in chronic insomnia: a voxel-based morphometric study. Biol Psychiatry 67:182-85.
Van Der Werf Y.D., Altena E., Van Dijk K.D., Strijers R.L.M., De Rijke W., Stam C.J. and Van Someren E.J.W. (2010) Is disturbed intracortical excitability a stable trait of chronic insomnia? A study using transcranial magnetic stimulation before and after multimodal sleep therapy. Biol Psychiatry 68:950–955.
Van Veen M.M., Kooij J.J.S., Boonstra A.M., Gordijn M.C.M. and Van Someren E.J.W. (2010) Delayed circadian rhythm in adults with ADHD and chronic sleep onset insomnia. Biol Psychiatry 67:1091-1096.
Van Der Werf Y.D., Van Der Helm E., Schoonheim M.M., Ridderikhoff A. and Van Someren E.J.W. (2009) Learning by observation requires an early sleep window. PNAS 106:18926-18930.
Van Der Werf, Y.D., Altena, E., Schoonheim, M.M., Sanz-Arigita, E., Vis, J.C., De Rijke, W. and Van Someren, E.J.W. (2009) Sleep benefits subsequent hippocampal functioning. Nat. Neurosci., 12: 122-123.
Hu, K., Van Someren, E.J.W., Shea, S.A. and Scheer, F.A. (2009) Reduction of scale invariance of activity fluctuations with aging and Alzheimer's disease: involvement of the circadian pacemaker. PNAS, 106: 2490-2494.
Riemersma-van der Lek R, Swaab DF, Twisk J, Hol EM, Hoogendijk WJG and Van Someren EJW (2008) Effect of bright light and melatonin on cognitive and non-cognitive function in elderly residents of group care facilities: a randomized controlled trial. JAMA 299:2642-2655.
Raymann RJEM, Swaab DF and Van Someren EJW (2008) Skin deep: cutaneous temperature determines sleep depth. Brain 131:500-513.
Altena E, Van Der Werf YD, Sanz Arigita EJ, Voorn T, Rombouts SARB, Kuijer JPA and Van Someren EJW (2008) Prefrontal hypoactivation and recovery in insomnia. Sleep 31:1271-1276.

Current/Completed Grants (past 5 years) Project NeuroSIPE 10738, of the Dutch Technology Foundation STW, which is part of the Netherlands Organization for Scientific Research (NWO) and partly funded by the Ministry of Economic Affairs, Agriculture and Innovation.
VICI Innovation Grant 453-07-001 of the Netherlands Organization of Scientific Research (NWO), The Hague.

Other laboratory Members
Title PhD First Name Ysbrand Last Name Van Der Werf Position senior E-Mail  
Title MSc First Name Johan Last Name Van Der Meer Position postdoc E-Mail  
Title PhD First Name Jennifer Last Name Ramautar Position postdoc E-Mail  
Title MSc First Name Filippo Last Name Migliorati Position postdoc E-Mail  
Title PhD First Name German Last Name Gomez-Herrero Position postdoc E-Mail  
Title MSc First Name Yvon Last Name Sweere Position behavioral therapist E-Mail  
Title MSc First Name Ilse Last Name Verweij Position PhD Candidate E-Mail  
Title MSc First Name Bart Last Name Te Lindert Position PhD Candidate E-Mail  
Title MSc First Name Nico Last Name Romeijn Position PhD Candidate E-Mail  
Title MSc First Name Yoshiyuki Last Name Onuki Position PhD Candidate E-Mail  
Title MSc First Name Sarah Last Name Moens Position PhD Candidate E-Mail  
Title MSc,MSc First Name Rebecca Last Name Astill Position PhD Candidate E-Mail  
Past Members