European Sleep Research Laboratories

Danish Center for Sleep Medicine

Current Announcements The center is a national center which receives patient from all part of Denmark, with all diagnoses of sleep areas including children and adults.
Main clinical areas includes sleep and neurological diseases including neurodegenerative disorders, parasomnias, epilepsy, movement disorders etc, sleep disordered breathing, circadian disorders and insomnias.

Department of Clinical Neurophysiology
Glostrup Hospital/University of Copenhagen

MD
Poul Jennum
Nordre Ringvej 57
2600 Glostrup Denmark


Position Professor Phone +4538632505 Fax +4543233933 Contact E-Mail poje@glo.regionh.dk Website http://www.glostruphospital.dk   Research Domain
  • Methodology / Technology
  • Clinical
  • Basic Human

Keywords
  • Molecular Biology-Endocrinology-Biochemistry
  • Sleep and Medical Disorders
  • Genetics of Sleep
  • Sleep and Ageing
  • Sleep and Psychiatry-Personality Disorders
  • Sleep and Body Functions (Cardio-Respiratory, Thermoregulation/Metabolism, Endocrine)
  • Sleep Physiology-Neurophysiology in Human
  • Paediatric Sleep Disorders
  • Neurological Sleep Disorders

Laboratory Description The laboratory include 6 in-hospital video-PSG beds in addition to the epilepsy monitoring unit with in total 8 beds. In addition full equipment facilities for ambulatory monitoring (PSG, cardio-respiratory monitoring, actigraphy etc.).
Treatment includes all types of positive airway pressure, medical treatment, psychology etc.
The laboratory present facilities for blood samples, saliva, spinal-fluid. The hospital includes full facilities for other diagnostic procedures (physiology, biochemetry, molecular biology, magnetic resonance, DAT scans etc.). Clinical departments includes neurology, psychiatry, internal medicine etc.

Technical Capabilities and areas of expertise Video-PSG facilities,
Ambulatory PSG and portable monitoring
Technical department
In-house engineers
Collaboration with the Danish Technical University

Additional Descriptors, Keywords Epidemiology
Clinical research
Human sleep research
Pathophysiology of sleep disorders

Selected Publications in the 5 past years 1: Fischer J, Dogas Z, Bassetti CL, Berg S, Grote L, Jennum P, Levy P, Mihaicuta S, Nobili L, Riemann D, Puertas Cuesta FJ, Raschke F, Skene DJ, Stanley N, Pevernagie D. Standard procedures for adults in accredited sleep medicine centres in Europe. J Sleep Res. 2011 Dec 2. doi: 10.1111/j.1365-2869.2011.00987.x. [Epub
ahead of print] PubMed PMID: 22133127.

3: Gustavsson A, Svensson M, Jacobi F, Allgulander C, Alonso J, Beghi E, Dodel R, Ekman M, Faravelli C, Fratiglioni L, Gannon B, Jones DH, Jennum P, Jordanova A, Jönsson L, Karampampa K, Knapp M, Kobelt G, Kurth T, Lieb R, Linde M, Ljungcrantz C, Maercker A, Melin B, Moscarelli M, Musayev A, Norwood F, Preisig M, Pugliatti M, Rehm J, Salvador-Carulla L, Schlehofer B, Simon R, Steinhausen HC, Stovner LJ, Vallat JM, den Bergh PV, van Os J, Vos P, Xu W, Wittchen HU, Jönsson B, Olesen J;
CDBE2010Study Group. Cost of disorders of the brain in Europe 2010. Eur Neuropsychopharmacol. 2011 Oct;21(10):718-79. Epub 2011 Sep 15. PubMed PMID:
21924589.

7: Mayer G, Jennum P, Riemann D, Dauvilliers Y. Insomnia in central neurologic diseases--occurrence and management. Sleep Med Rev. 2011 Dec;15(6):369-78. Epub 2011 Apr 9. PubMed PMID: 21481621.

10: Knudsen S, Mikkelsen JD, Bang B, Gammeltoft S, Jennum PJ. Intravenous immunoglobulin treatment and screening for hypocretin neuron-specific autoantibodies in recent onset childhood narcolepsy with cataplexy. Neuropediatrics. 2010 Oct;41(5):217-22. Epub 2011 Jan 5. PubMed PMID: 21210337.

11: Jennum P, Kjellberg J. Health, social and economical consequences of sleep-disordered breathing: a controlled national study. Thorax. 2011 Jul;66(7):560-6. Epub 2011 Jan 2. PubMed PMID: 21199816.

12: Kornum BR, Kawashima M, Faraco J, Lin L, Rico TJ, Hesselson S, Axtell RC, Kuipers H, Weiner K, Hamacher A, Kassack MU, Han F, Knudsen S, Li J, Dong X, Winkelmann J, Plazzi G, Nevsimalova S, Hong SC, Honda Y, Honda M, Högl B, Ton TG, Montplaisir J, Bourgin P, Kemlink D, Huang YS, Warby S, Einen M, Eshragh JL, Miyagawa T, Desautels A, Ruppert E, Hesla PE, Poli F, Pizza F, Frauscher B, Jeong JH, Lee SP, Strohl KP, Longstreth WT Jr, Kvale M, Dobrovolna M, Ohayon MM, Nepom GT, Wichmann HE, Rouleau GA, Gieger C, Levinson DF, Gejman PV, Meitinger T, Peppard P, Young T, Jennum P, Steinman L, Tokunaga K, Kwok PY, Risch N, Hallmayer J, Mignot E. Common variants in P2RY11 are associated with narcolepsy. Nat Genet. 2011 Jan;43(1):66-71. Epub 2010 Dec 19. PubMed PMID: 21170044; PubMed Central
PMCID: PMC3019286.

13: Fietze I, Penzel T, Alonderis A, Barbe F, Bonsignore MR, Calverly P, De Backer W, Diefenbach K, Donic V, Eijsvogel MM, Franklin KA, Gislason T, Grote L, Hedner J, Jennum P, Lavie L, Lavie P, Levy P, Lombardi C, Mallin W, Marrone O, Montserrat JM, Papathanasiou ES, Parati G, Plywaczewski R, Pretl M, Riha RL, Rodenstein D, Saaresranta T, Schulz R, Sliwinski P, Steiropoulos P, Svaza J, Tomori Z, Tonnesen P, Varoneckas G, Verbraecken J, Vesely J, Vitols A, Zielinski J, McNicholas WT; COST Action B26 Group. Management of obstructive sleep apnea in Europe. Sleep Med. 2011 Feb;12(2):190-7. Epub 2010 Dec 16. PubMed PMID: 21167776.

15: Kempfner J, Sorensen G, Zoetmulder M, Jennum P, Sorensen HB. REM behaviour disorder detection associated with neurodegenerative diseases. Conf Proc IEEE Eng Med Biol Soc. 2010;2010:5093-6. PubMed PMID: 21096034.

16: Hor H, Kutalik Z, Dauvilliers Y, Valsesia A, Lammers GJ, Donjacour CE, Iranzo A, Santamaria J, Peraita Adrados R, Vicario JL, Overeem S, Arnulf I, Theodorou I, Jennum P, Knudsen S, Bassetti C, Mathis J, Lecendreux M, Mayer G, Geisler P, Benetó A, Petit B, Pfister C, Bürki JV, Didelot G, Billiard M, Ercilla G, Verduijn W, Claas FH, Vollenweider P, Waeber G, Waterworth DM, Mooser V, Heinzer R, Beckmann JS, Bergmann S, Tafti M. Genome-wide association study identifies new HLA class II haplotypes strongly protective against narcolepsy. Nat Genet. 2010
Sep;42(9):786-9. Epub 2010 Aug 15. Erratum in: Nat Genet. 2011 Apr;43(4):388. Vollenwider, Peter [corrected to Vollenweider, Peter]. PubMed PMID: 20711174.

17: Jensen PS, Sorensen HB, Leonthin HL, Jennum P. Automatic sleep scoring in normals and in individuals with neurodegenerative disorders according to new international sleep scoring criteria. J Clin Neurophysiol. 2010
Aug;27(4):296-302. PubMed PMID: 20634706.

18: Kawashima M, Lin L, Tanaka S, Jennum P, Knudsen S, Nevsimalova S, Plazzi G, Mignot E. Anti-Tribbles homolog 2 (TRIB2) autoantibodies in narcolepsy are associated with recent onset of cataplexy. Sleep. 2010 Jul;33(7):869-74. PubMed PMID: 20614846; PubMed Central PMCID: PMC2894428.

21: Knudsen S, Jennum PJ, Alving J, Sheikh SP, Gammeltoft S. Validation of the ICSD-2 criteria for CSF hypocretin-1 measurements in the diagnosis of narcolepsy in the Danish population. Sleep. 2010 Feb;33(2):169-76. PubMed PMID: 20175400; PubMed Central PMCID: PMC2817904.

22: Knudsen S, Gammeltoft S, Jennum PJ. Rapid eye movement sleep behaviour disorder in patients with narcolepsy is associated with hypocretin-1 deficiency. Brain. 2010 Feb;133(Pt 2):568-79. Epub 2010 Feb 3. PubMed PMID: 20129934.

23: Jennum P, Kjellberg J. The socio-economical burden of hypersomnia. Acta Neurol Scand. 2010 Apr;121(4):265-70. Epub 2009 Dec 28. PubMed PMID: 20047573.

24: Jennum P, Knudsen S, Kjellberg J. The economic consequences of narcolepsy. J Clin Sleep Med. 2009 Jun 15;5(3):240-5. PubMed PMID: 19960645; PubMed Central PMCID: PMC2699169.

27: Biering-Sørensen F, Jennum P, Laub M. Sleep disordered breathing following spinal cord injury. Respir Physiol Neurobiol. 2009 Nov 30;169(2):165-70. Epub 2009 Sep 1. Review. PubMed PMID: 19729080.

30: Hajak G, Hedner J, Eglin M, Loft H, Stórustovu SI, Lütolf S, Lundahl J; Gaboxadol Study 99775 Group. A 2-week efficacy and safety study of gaboxadol and zolpidem using electronic diaries in primary insomnia outpatients. Sleep Med. 2009 Aug;10(7):705-12. Epub 2009 Apr 5. PubMed PMID: 19346160.

31: Jennum P, Riha RL. Epidemiology of sleep apnoea/hypopnoea syndrome and sleep-disordered breathing. Eur Respir J. 2009 Apr;33(4):907-14. Review. PubMed
PMID: 19336593.

32: Rodenstein D; Cost-B26 Action on Sleep Apnoea Syndrome. Driving in Europe: the need of a common policy for drivers with obstructive sleep apnoea syndrome. J Sleep Res. 2008 Sep;17(3):281-4. Epub 2008 Jul 22. PubMed PMID: 18651866.

33: Bing MH, Moller LA, Jennum P, Mortensen S, Lose G. Nocturia and associated morbidity in a Danish population of men and women aged 60-80 years. BJU Int. 2008 Sep;102(7):808-14; discussion 814-5. Epub 2008 Jun 28. PubMed PMID: 18564133.

34: Knudsen S, Jennum PJ, Korsholm K, Sheikh SP, Gammeltoft S, Frederiksen JL. Normal levels of cerebrospinal fluid hypocretin-1 and daytime sleepiness during attacks of relapsing-remitting multiple sclerosis and monosymptomatic optic neuritis. Mult Scler. 2008 Jul;14(6):734-8. Epub 2008 May 27. PubMed PMID:
18505777.

35: Arnulf I, Nielsen J, Lohmann E, Schiefer J, Wild E, Jennum P, Konofal E, Walker M, Oudiette D, Tabrizi S, Durr A. Rapid eye movement sleep disturbances in Huntington disease. Arch Neurol. 2008 Apr;65(4):482-8. Erratum in: Arch Neurol. 2008 Nov;65(11):1478.. Schieffer, Johannes [corrected to Schiefer,Johannes].
PubMed PMID: 18413470.

37: Riha RL, Diefenbach K, Jennum P, McNicholas WT; Management Committee, COST B26 Action on Sleep Apnoea Syndrome. Genetic aspects of hypertension and metabolic disease in the obstructive sleep apnoea-hypopnoea syndrome. Sleep Med Rev. 2008 Feb;12(1):49-63. Review. PubMed PMID: 18201663.


38: Jennum P, Santamaria J; Members of the Task Force. Report of an EFNS taskforce on management of sleep disorders in neurologic disease (degenerative neurologic disorders and stroke). Eur J Neurol. 2007 Nov;14(11):1189-200. Review.
PubMed PMID: 17956442.


40: Alonderis A, Barbé F, Bonsignore M, Calverley P, De Backer W, Diefenbach K, Donic V, Fanfulla F, Fietze I, Franklin K, Grote L, Hedner J, Jennum P, Krieger J, Levy P, McNicholas W, Montserrat J, Parati G, Pascu M, Penzel T, Riha R, Rodenstein D, Sanna A, Schulz R, Sforza E, Sliwinski P, Tomori Z, Tonnesen P, Varoneckas G, Zielinski J, Kostelidou K; COST Action B-26. Medico-legal implications of sleep apnoea syndrome: driving license regulations in Europe. Sleep Med. 2008 May;9(4):362-75. Epub 2007 Aug 31. PubMed PMID: 17765641.


41: Bing MH, Moller LA, Jennum P, Mortensen S, Lose G. Pathophysiological aspects of nocturia in a danish population of men and women age 60 to 80 years. J Urol. 2007 Aug;178(2):552-7. Epub 2007 Jun 14. PubMed PMID: 17570415.

43: Knudsen S, Mikkelsen JD, Jennum P. Antibodies in narcolepsy-cataplexy patient serum bind to rat hypocretin neurons. Neuroreport. 2007 Jan 8;18(1):77-9. PubMed
PMID: 17259865.


45: Bing MH, Moller LA, Jennum P, Mortensen S, Skovgaard LT, Lose G. Prevalence and bother of nocturia, and causes of sleep interruption in a Danish population of men and women aged 60-80 years. BJU Int. 2006 Sep;98(3):599-604. Epub 2006 Jul
7. PubMed PMID: 16827903.


47: Bing MH, Moller LA, Jennum P, Mortensen S, Lose G. Validity and reliability of a questionnaire for evaluating nocturia, nocturnal enuresis and sleep-interruptions in an elderly population. Eur Urol. 2006 Apr;49(4):710-9. Epub 2006 Jan 13. PubMed PMID: 16442700.


50: Bastlund JF, Jennum P, Mohapel P, Penschuck S, Watson WP. Spontaneous epileptic rats show changes in sleep architecture and hypothalamic pathology.Epilepsia. 2005 Jun;46(6):934-8. PubMed PMID: 15946334.


Key Publications of the Laboratory Jennum P, Kjellberg J. Health, social and economical consequences of sleep-disordered breathing: a controlled national study. Thorax. 2011 Jul;66(7):560-6. Epub 2011 Jan 2. PubMed PMID: 21199816.

Hor H, Kutalik Z, Dauvilliers Y, Valsesia A, Lammers GJ, Donjacour CE, Iranzo A, Santamaria J, Peraita Adrados R, Vicario JL, Overeem S, Arnulf I, Theodorou I, Jennum P, Knudsen S, Bassetti C, Mathis J, Lecendreux M, Mayer G, Geisler P, Benetó A, Petit B, Pfister C, Bürki JV, Didelot G, Billiard M, Ercilla G, Verduijn W, Claas FH, Vollenweider P, Waeber G, Waterworth DM, Mooser V, Heinzer R, Beckmann JS, Bergmann S, Tafti M. Genome-wide association study identifies new HLA class II haplotypes strongly protective against narcolepsy. Nat Genet. 2010 Sep;42(9):786-9. Epub 2010 Aug 15. Erratum in: Nat Genet. 2011 Apr;43(4):388.

Kornum BR, Kawashima M, Faraco J, Lin L, Rico TJ, Hesselson S, Axtell RC, Kuipers H, Weiner K, Hamacher A, Kassack MU, Han F, Knudsen S, Li J, Dong X, Winkelmann J, Plazzi G, Nevsimalova S, Hong SC, Honda Y, Honda M, Högl B, Ton TG, Montplaisir J, Bourgin P, Kemlink D, Huang YS, Warby S, Einen M, Eshragh JL, Miyagawa T, Desautels A, Ruppert E, Hesla PE, Poli F, Pizza F, Frauscher B, Jeong JH, Lee SP, Strohl KP, Longstreth WT Jr, Kvale M, Dobrovolna M, Ohayon MM, Nepom GT, Wichmann HE, Rouleau GA, Gieger C, Levinson DF, Gejman PV, Meitinger T, Peppard P, Young T, Jennum P, Steinman L, Tokunaga K, Kwok PY, Risch N, Hallmayer J, Mignot E. Common variants in P2RY11 are associated with narcolepsy. Nat Genet. 2011 Jan;43(1):66-71

Knudsen S, Jennum PJ, Alving J, Sheikh SP, Gammeltoft S. Validation of the ICSD-2 criteria for CSF hypocretin-1 measurements in the diagnosis of narcolepsy in the Danish population. Sleep. 2010 Feb;33(2):169-76.

Knudsen S, Gammeltoft S, Jennum PJ. Rapid eye movement sleep behaviour disorder in patients with narcolepsy is associated with hypocretin-1 deficiency. Brain. 2010 Feb;133(Pt 2):568-79.

 
Other laboratory Members
 
Collaborations
 
Title MSc,PhD First Name Helge Middle Name D Last Name Sørensen Position Assoc Prof Institution The Technical University of Denmark  
Past Members